Methyl iodide → HCID 131710137, Verbindung

To a solution of 6.2 g. of crystalline antibiotic X-537A in 125 ml. of methylene chloride was added 4.6 g. of silver oxide and 14 g. of methyl iodide. After stirring for 18 hours, the reaction mixture was filtered and the filtrate concentrated to 7.07 g. of a light yellow oil, which was decolorized with Darco, giving 6.09 g. of a colorless foam. A portion (4 g.) of the foam was chromatographed on a florisil column (150 g.) eluting with a gradient between methylene chloride (1 l.) to ether (1 l.) and then ether (500 ml.) to acetone (500 ml.). Rechromatography of the slightly yellow oil, recovered from the florisil column, on a 75 g. silica gel column and eluting with a gradient between methylene chloride (1 l.) and 15 percent ether/-methylene chloride gave 200 mg. of a clear viscous oil, Bp. 170°d/005 mm. [α] D25 -7.19° , (1.1 percent CH3OH).

1. filtrationthe reaction mixture was filtered
2. concentrationthe filtrate concentrated to 7.07 g
3. customgiving 6.09 g
4. customA portion (4 g.) of the foam was chromatographed on a florisil column (150 g.)
5. washeluting with a gradient between methylene chloride (1 l.) to ether (1 l.)
6. customRechromatography of the slightly yellow oil, recovered from the florisil column, on a 75 g
7. washsilica gel column and eluting with a gradient between methylene chloride (1 l.) and 15 percent ether/-methylene chloride
8. customgave 200 mg

ORD-Eintrag

ord-5589b77f734a4aae9bb73d9cd7ac7bf9

Quelldatensatz

uspto-grants-1978_05

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

USRE029651