Grundinformationen
- Standard-SMILES
CCOc1ccccc1OCCN[C@H](C)Cc1ccc(OC)c(S(N)(=O)=O)c1.Cl- InChIKey
ZZIZZTHXZRDOFM-XFULWGLBSA-N- Summenformel
- C20H29ClN2O5S
- Durchschnittliche Molmasse
- 445 g/mol
- Monoisotopische Masse
- 444,14857071
Überblick
Tamsulosin hydrochloride is a hydrochloride resulting from the reaction of equimolar amounts of tamulosin and hydrogen chloride. It has a role as an antineoplastic agent and an alpha-adrenergic antagonist. It contains a tamsulosin(1+). It is an enantiomer of an ent-tamsulosin hydrochloride.
Namen und Bezeichner
- Bevorzugter Name
- Tamsulosin Hydrochloride
- IUPAC
- 5-[(2R)-2-[2-(2-ethoxyphenoxy)ethylamino]propyl]-2-methoxybenzenesulfonamide;hydrochloride
Namen und Synonyme
TAMSULOSIN HYDROCHLORIDE106463-17-6Tamsulosin HClHarnalPradifYM617LY253351R-(-)-YM-12617DTXSID2046628Flomax MRYM-12617-1LY-253351
Weitere Namen anzeigen
11SV1951MR(-)-(R)-5-(2-((2-(o-Ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide monohydrochlorideR-(-)-5-(2-((2-(2-Ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide hydrochlorideCHEBI:9399DTXCID0026628Benzenesulfonamide, 5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxy-, monohydrochloride, (R)-JALYN COMPONENT TAMSULOSIN HYDROCHLORIDEDiffundox
Datenbank-Bezeichner
- CAS
106463-17-6- PubChem CID
- 5362376
- DTXSID
DTXSID2046628- ChEMBL
CHEMBL1200914- ChEBI
CHEBI:9399- UNII
- 11SV1951MR
- EC Number
- 629-756-5
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 108 Ų
- H-Brücken-Donoren
- 3
- H-Brücken-Akzeptoren
- 7
- Frei drehbare Bindungen
- 11
- Schwere Atome
- 29
- Formalladung
- 0
- Komplexität
- 539
Experimentelle und physikochemische Eigenschaften
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Sicherheit und Regulatorisches
GHS-Klassifizierung
GHS Classification
Warning
H302 (99.2%): Harmful if swallowed [Warning Acute toxicity, oral]
P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 133 reports by companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Hazard Classes and CategoriesAcute Tox. 4 (99.2%)
Toxikologische Informationen
Drug Induced Liver Injury
Drug Induced Liver Injury Rank (DILIrank 2.0)
Tamsulosin hydrochloride
vLess-DILI-concern
0
No match
DOI:10.1016/j.drudis.2016.02.015
Chemie und Industrie
Pharmakologische Informationen
FDA Pharmacological Classification
TAMSULOSIN HYDROCHLORIDE
Adrenergic alpha-Antagonists [MoA]; alpha-Adrenergic Blocker [EPC]
MeSH Pharmacological Classification
Drugs that bind to and block the activation of ADRENERGIC ALPHA-1 RECEPTORS.
Drugs used in the treatment of urological conditions and diseases such as URINARY INCONTINENCE and URINARY TRACT INFECTIONS.
Zugehörige Reaktionen
6
Verknüpfte Notizen
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