Paroxetine → Paroxetine Hydrochloride

HRID 1633552

Reaktionsgleichung

Reaktionsgleichung von HRID 1633552
CCOC1C(OCCN[C@@H](CC2C=CC(OC)=C(S(N)(=O)=O)C=2)C)=CC=CC=1.[ClH:29].[K+].[Br-].[CH:32]1[C:37]([C@H:38]2[C@H:43]([CH2:44][O:45][C:46]3[CH:47]=[CH:48][C:49]4[O:54][CH2:53][O:52][C:50]=4[CH:51]=3)[CH2:42][NH:41][CH2:40][CH2:39]2)=[CH:36][CH:35]=[C:34]([F:55])[CH:33]=1>>[CH:36]1[C:37]([C@H:38]2[C@H:43]([CH2:44][O:45][C:46]3[CH:47]=[CH:48][C:49]4[O:54][CH2:53][O:52][C:50]=4[CH:51]=3)[CH2:42][NH:41][CH2:40][CH2:39]2)=[CH:32][CH:33]=[C:34]([F:55])[CH:35]=1.[ClH:29]

Komponenten

4

Edukt 3

HCID 43815ParoxetineHCID 253877Potassium BromideHCID 5362376Tamsulosin Hydrochloride

Produkt 1

HCID 62878Paroxetine Hydrochloride

Versuchsvorschrift

The composition of the solid was tested by FTIR. A Nicolet Magna IR System 750 Fourier Transform Infrared Spectrometer controlled via Nicolet Omnic ESP® software was used to obtain the spectra. A KBr beamsplitter was used and data was collected over 4000−400 cm−1 with a resolution of 4 cm−1. An MCT-A detector, cooled with liquid nitrogen, was used. The sample compartment was under constant nitrogen purge. The aperture was set at 28, the micro velocity was 1.8988 and the gain setting was 1. The contact sampler attachment, which is a horizontal internal reflection accessory, with a trough cell, containing the ZnSe 45° ATR crystal, was used. The background spectrum was air. The spectrum was obtained by averaging 100 scans. The findings were consistent with published spectra for paroxetine.

Aufarbeitung

  1. customto obtain the spectra
  2. customdata was collected over 4000−400 cm−1 with a resolution of 4 cm−1
  3. temperatureAn MCT-A detector, cooled with liquid nitrogen
  4. custompurge
  5. additionwith a trough cell, containing the ZnSe 45° ATR crystal
  6. customThe spectrum was obtained

Quellen und Nachweise

ORD-Eintrag
ord-7122681899ae4fe88d17f372baa3e058
Quelldatensatz
uspto-grants-2003_01
Patentnummer
US06503927B1

Verknüpfte Notizen

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