Vinblastine Sulfate

HCID 5388983CAS 143-67-9

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Grundinformationen

Standard-SMILES: CC[C@]1(O)C[C@@H]2CN(CCc3c([nH]c4ccccc34)[C@@](C(=O)OC)(c3cc4c(cc3OC)N(C)[C@H]3[C@@](O)(C(=O)OC)[C@H](OC(C)=O)[C@]5(CC)C=CCN6CC[C@]43[C@@H]65)C2)C1.O=S(=O)(O)O
InChIKey: KDQAABAKXDWYSZ-PNYVAJAMSA-N
Summenformel: C46H58N4O9.H2O4S
Durchschnittliche Molmasse: 909,1 g/mol
Monoisotopische Masse: 908,38775898

Überblick

Vinblastine Sulfate can cause developmental toxicity according to state or federal government labeling requirements.

Namen und Bezeichner

Bevorzugter Name: Vinblastine Sulfate
IUPAC: methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate;sulfuric acid

Namen und Synonyme

Vinblastine sulfate143-67-9VelsarAlkaban-aqVinblastine sulphateVLB monosulfate29060-LEVincaleucoblastine sulfateVinblastini sulfasNSC-49842N00W22YO2BVincaleukoblastine, sulfate (1:1) (salt)

Weitere Namen anzeigen

29060LE29060 LENSC 49842DTXSID601017133CHEBI:9984Vinblast,lederleSulfate, VinblastineRefChem:56475

Datenbank-Bezeichner

CAS: 143-67-9
PubChem CID: 5388983
DTXSID: DTXSID601017133
ChEMBL: CHEMBL378544
UNII: N00W22YO2B
EC Number: 205-606-0

Eigenschaften

Berechnete Struktureigenschaften

Polarare Oberfläche (TPSA): 237 Å²
H-Brücken-Donoren: 5
H-Brücken-Akzeptoren: 16
Frei drehbare Bindungen: 10
Schwere Atome: 64
Formalladung: 0
Komplexität: 1.780

Experimentelle und physikochemische Eigenschaften

Solubilitygreater than or equal to 10 mg/mL at 76.1 °F (NTP, 1992)

Human Drugs · 3 Einträge

Breast Feeding; Lactation; Milk, Human; Antineoplastic Agents; Antimitotic Agents

FDA approved drugs -> Active ingredient

Melting Point543 to 545 °F (NTP, 1992)

Physical DescriptionVinblastine sulfate appears as an anticancer drug. White to slightly yellow crystalline powder. (NTP, 1992)

Collision Cross Section278.5 Å² [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 4 Einträge

Danger

H302 (99%): Harmful if swallowed [Warning Acute toxicity, oral]

P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P354+P338, P317, P319, P321, P330, P332+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 98 reports by companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Gefahrenhinweise

Regulatory InformationHazard Traits - Developmental Toxicity

Other Safety InformationIMAP assessments - Vincaleukoblastine, sulfate (1:1) (salt): Environment tier I assessment

DOT LabelPoison

Fire HazardsFlash point data for this chemical are not available; however it is probably combustible. (NTP, 1992)

Health Hazards · 1 Eintrag

SYMPTOMS: Symptoms of exposure to this chemical include temporary mental depression, paresthesias, loss of deep-tendon reflexes, headache, convulsions, psychoses; dysfunction of the autonomic nervous system, with marked constipation, paralytic ileus, urinary retention, bilateral pain and tenderness of the parotid glands associated with dryness of the mouth, sinus tachycardia; nausea, vomiting, anorexia, diarrhea; loss of hair, vesicular mucositis of the mouth, and dermatitis. (NTP, 1992)

Reactive GroupAlcohols and Polyols

Sicherheit und Schutzausrüstung

Fire FightingFires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

First Aid · 1 Eintrag

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Nonfire Spill Response · 1 Eintrag

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

Isolation and EvacuationExcerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:

Personal Protective Equipment (PPE) · 1 Eintrag

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)