2-Mercaptobenzoesure
2-Mercaptobenzoic Acid
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Grundinformationen
- CAS
147-93-3- Standard-SMILES
O=C(O)c1ccccc1S- InChIKey
NBOMNTLFRHMDEZ-UHFFFAOYSA-N- Summenformel
- C7H6O2S
- Durchschnittliche Molmasse
- 154,19 g/mol
- Monoisotopische Masse
- 154,0088506
Überblick
Thiosalicylic acid is a sulfanylbenzoic acid that is the 2-sulfanyl derivative of benzoic acid. It has a role as a non-narcotic analgesic and an antipyretic. It is a conjugate acid of a thiosalicylate(1-).
Namen und Bezeichner
- Bevorzugter Name
- 2-Mercaptobenzoic Acid
- IUPAC
- 2-sulfanylbenzoic acid
- Lokaler Name
- 2-Mercaptobenzoesure
- Englischer Name
- Thiosalicylic acid
- Summenformel
- C7H6O2S
- Molmasse
- 154.19
Namen und Synonyme
Thiosalicylic acid2-Mercaptobenzoic acid147-93-32-Sulfanylbenzoic acido-Mercaptobenzoic acid2-Thiosalicylic acido-Thiosalicylic acid2-Carboxythiophenolo-Sulfhydrylbenzoic acido-Benzoic acid thiolo-CarboxythiophenolBenzoic acid, 2-mercapto-
Weitere Namen anzeigen
Thiosalicylic2-Thiobenzoic acidTHIOSALYCYLIC ACIDicyiLusafkf-2NSC 2184NSC 6664
o-MercaptobenzoesaeureSalicylic acid, 2-thio-BENZOIC ACID, O-MERCAPTO-Thiophenol-2-carboxylic acidCIP6LXN5XWDTXSID4049032NSC-2184NSC-660640
Datenbank-Bezeichner
- CAS
147-93-3- PubChem CID
- 5443
- DTXSID
DTXSID4049032- ChEMBL
CHEMBL119888- ChEBI
CHEBI:59124- UNII
- CIP6LXN5XW
Eigenschaften
Berechnete StruktureigenschaftenWird ergänzt
- XLogP
- 2,4
- Polarare Oberfläche (TPSA)
- 38,3 Ų
- H-Brücken-Donoren
- 2
- H-Brücken-Akzeptoren
- 3
- Frei drehbare Bindungen
- 1
- Schwere Atome
- 10
- Formalladung
- 0
- Komplexität
- 136
Experimentelle und physikochemische Eigenschaften
Chemical ClassesOther Classes -> Benzoic Acid Derivatives
DrugsPharmaceuticals -> Listed in ZINC15
CosmeticsKeratolytic; Reducing; Antioxidant
SpringerMaterials PropertiesChemical shift
LogP2.39
Color/Form
SULFUR-YELLOW FLAKES, PLATES, NEEDLES FROM GLACIAL ACETIC ACID OR ALCOHOL
LEAVES OR NEEDLES FROM WATER
CRYSTALS /SODIUM SALT/
Solubility
SOL IN WATER /SODIUM SALT/
SOL IN HOT WATER, ALCOHOL, ETHER, ACETIC ACID; SLIGHTLY SOLUBLE IN PETROLEUM ETHER
Melting Point168-169 °C
Physical DescriptionSulfur-yellow solid; Slightly soluble in hot water; [Merck Index] Yellow powder, soluble in water; [MSDSonline]
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Warning
H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 50 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Regulatory Information
Chemical: Benzoic acid, 2-mercapto-
Thiosalicylic acid: Does not have an individual approval but may be used under an appropriate group standard
Hazard Classes and CategoriesSkin Irrit. 2 (100%)
Sicherheit und Schutzausrüstung
Protective Action Criteria (PAC)
0.16 [mg/m3]
1.8 [mg/m3]
11 [mg/m3]
Toxikologische Informationen
Non-Human Toxicity ExcerptsUNCOUPLING OF OXIDATIVE PHOSPHORYLATION IN RAT LIVER MITOCHONDRIA WAS INVESTIGATED WITH THIO ANALOGS OF SALICYLIC ACID. SIGNIFICANT ACTIVITY WAS OBSERVED.
Sicherheitsdaten
- F
Chemie und Industrie
Pharmakologische Informationen
MeSH Pharmacological ClassificationA subclass of analgesic agents that typically do not bind to OPIOID RECEPTORS and are not addictive. Many non-narcotic analgesics are offered as NONPRESCRIPTION DRUGS.
Verwendung und Herstellung
Uses
Used in the manufacture of thioindigo dyes and other chemicals and as a reagent for determination of iron; [HSDB]
MANUFACTURE OF THIOINDIGO DYES, REAGENT FOR DETERMINATION OF IRON
AS INTERMEDIATE
Methods of Manufacturing
PREPARED BY HEATING O-HALOGENATED BENZOIC ACIDS WITH ALKALINE HYDROSULFIDE IN PRESENCE OF COPPER; GERMAN PATENT 189,200 (1906); BY REDUCTION OF DITHIOSALICYLIC ACID: CLAASZ; BER 45, 2427 (1912); GERMAN PATENT 205,450; ALLEN, MACKAY, ORG SYN 12, 76 (1932).
Formulations/PreparationsGRADES: REAGENT; TECHNICAL, 80%; PHARMACEUTICAL.
Use ClassificationCosmetics -> Keratolytic; Reducing; Antioxidant
General Manufacturing InformationBenzoic acid, 2-mercapto-: ACTIVE
Anwendungen
VerwendenThiosalicylic acid acts as a trapping agent, which is useful in the desulfenylation of 3-indolyl sulfides. It is used to prepare macrocyclic diamides by condensation with diamines. Further, it is used as a precursor to drug, which finds application for the treatment of atherosclerosis and melanoma. In addition to this, it is involved in the preparation of vaccine preservative thiomersal and thioindigo dyestuff.
Darstellung
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