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Arsenous acid
Arsenous acid (9CI) · Arsenous acid (as As) · GCPXMJHSNVMWNM-UHFFFAOYSA-N · Carbon Dioxide in Nitrogen (Nominal Amount-of-Substance Fraction 500 μmol/mol)
Identifikatoren & physikalische Daten
| CAS No. | 13464-58-9 |
|---|---|
| Summenformel | AsH3O3 |
| Durchschnittliche Molmasse | 125,944 g/mol |
| Monoisotopische Masse | 125,929814 g/mol |
| SMILES | O[As](O)O |
| InChIKey | GCPXMJHSNVMWNM-UHFFFAOYSA-N |
| PubChem CID | 545 |
| ChEMBL | CHEMBL1236189 |
| ChEBI | CHEBI:49900 |
| DTXSID | DTXSID7074828 |
Chemische & physikalische Eigenschaften
| Polarare Oberfläche (TPSA) | 60,7 |
|---|---|
| H-Brücken-Donoren | 3 |
| H-Brücken-Akzeptoren | 3 |
| Frei drehbare Bindungen | 0 |
| Schwere Atome | 4 |
| Formalladung | 0 |
| Komplexität | 8 |
| Stoffklassen | Metals -> Arsenic Compounds, Inorganic |
| Siedepunkt | 465 °C |
| Physical Description | SolidV (@25 °C) |
| Aggregatzustand | exists only in solution |
| pKa (Säurekonstante) | 6.86±0.53(Predicted) |
| Farbe | exists only in solution |
| EPA chemische Informationen | Arsenous acid (13464-58-9) |
Sicherheit & Vorschriften
| Gefahrenübersicht | See Arsenic and the linked occupational diseases. |
|---|---|
| Expositionsschutz und Persönliche Schutzausrüstung | Biological Exposure Indices (BEI) [ACGIH] - Inorganic arsenic plus methylated metabolites in urine = 35 ug As/Lend of workweek |
| Minimum Risk Level | Acute Oral: 0.005 mg/kg/day (L134) Chronic Oral: 0.0003 mg/kg/day (L134) Chronic Inhalation: 0.01 mg/m3 (L134) |
| Threshold Limit Values (TLV) | 0.01 [mg/m3], as As |
| Permissible Exposure Limit (PEL) | 0.01 [mg/m3], as As |
| Protective Action Criteria (PAC) | 0.050 [mg/m3]0.78 [mg/m3]4.7 [mg/m3] |
| Immediately Dangerous to Life or Health (IDLH) | 5.0 [mg/m3], as As |
| Treatment | Arsenic poisoning can be treated by chelation therapy, using chelating agents such as dimercaprol, EDTA or DMSA. Charcoal tablets may also be used for less severe cases. In addition, maintaining a diet high in sulfur helps eliminate arsenic from the body. (L20) |
| Gesundheitliche Auswirkungen | Arsenic poisoning can lead to death from multi-system organ failure, probably from necrotic cell death, not apoptosis. Arsenic is also a known carcinogen, esepcially in skin, liver, bladder and lung cancers. (T1, L20) |
| Unerwünschte Wirkungen | Neurotoxin - Sensorimotor |
| Expositionspfade | Oral (L2)inhalation (L2)dermal (L2) |
| Toxizitätsübersicht | Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. Arsenic's carginogenicity is influenced by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. The binding of other arsenic protein targets may also cause altered DNA repair enzyme activity, altered DNA methylation patterns and cell proliferation. (T1, A17) |
Anwendungen & Verwendung
Verwenden
Pesticides.