Grundinformationen
- CAS
59-98-3- Standard-SMILES
c1ccc(CC2=NCCN2)cc1- InChIKey
JIVZKJJQOZQXQB-UHFFFAOYSA-N- Summenformel
- C10H12N2
- Durchschnittliche Molmasse
- 160,22 g/mol
- Monoisotopische Masse
- 160,10004839
Überblick
Tolazoline is a member of the class of imidazoles that is 4,5-dihydro-1H-imidazole substituted by a benzyl group. It has a role as a vasodilator agent, an antihypertensive agent and an alpha-adrenergic antagonist.
Namen und Bezeichner
- Bevorzugter Name
- Tolazoline
- IUPAC
- 2-benzyl-4,5-dihydro-1H-imidazole
- Lokaler Name
- Tolazolin
- Englischer Name
- Tolazoline
- Summenformel
- C10H12N2
- Molmasse
- 160.22
Namen und Synonyme
tolazoline59-98-32-Benzylimidazoline2-Benzyl-4,5-dihydro-1H-imidazoleBenzazoline2-Benzyl-2-imidazoline2-Benzyl-4,5-imidazolineTolazolinaTolazineTolazolinum4,5-Dihydro-2-(phenylmethyl)-1H-imidazole1H-Imidazole, 4,5-dihydro-2-(phenylmethyl)-
Weitere Namen anzeigen
PriscolineVasodilVasimidArtonilKasimidLambrilPriscolBenzolinciba3259
CHH9H12AQ3NSC-35110BenzalolinDTXSID3023683CHEBI:28502RefChem:56141DTXCID103683C04AB02
Datenbank-Bezeichner
- CAS
59-98-3- PubChem CID
- 5504
- DTXSID
DTXSID3023683- ChEMBL
CHEMBL770- ChEBI
CHEBI:28502
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 2,6
- Polarare Oberfläche (TPSA)
- 24,4 Ų
- H-Brücken-Donoren
- 1
- H-Brücken-Akzeptoren
- 1
- Frei drehbare Bindungen
- 2
- Schwere Atome
- 12
- Formalladung
- 0
- Komplexität
- 169
Experimentelle und physikochemische Eigenschaften
DrugsPharmaceuticals -> Listed in ZINC15
LogP1.5
Solubility1.36e+00 g/L
Melting Point174 °C
Physical DescriptionSolid
Dissociation Constants10.3
Collision Cross Section133.41 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
Physikochemische Eigenschaften
- Schmelzpunkt
- 66 · 66-69 °C(lit.)
- Siedepunkt
- 188 °C/20mmHg · 188°C/20mmHg(lit.)
- Dichte
- 1.0849 · 1.0849 (rough estimate)
- Brechungsindex
- 1.6392 · 1.6392 (estimate)
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Warning
H302+H312+H332 (44.1%): Harmful if swallowed, in contact with skin or if inhaled [Warning Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]
P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 68 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Regulatory InformationTolazoline: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Other Safety InformationIMAP assessments - 1H-Imidazole, 4,5-dihydro-2-(phenylmethyl)-: Human health tier I assessment
Hazard Classes and CategoriesAcute Tox. 4 (100%)
Sicherheitsdaten
- wgk
- 3
- hs_code
- 2933299090
- RTECS-Nr.
- NJ1925000
- risk_code
- 20/21/22-36/37/38
- Toxizität
- cyt-ham:lng 62,500 mg/L GMCRDC 27,95,81
- hazard_code
- Xn
- safety_code
- 26-28-36/37/39-45
- Speicherklasse
- 11 - Combustible Solids
Chemie und Industrie
Pharmakologische Informationen
ATC Code
C - Cardiovascular system
M - Musculo-skeletal system
QC - Cardiovascular system
QV - Various
QM - Musculo-skeletal system
PharmacodynamicsTolazoline is a pulmonary vasodilator indicated used to decrease pulmonary vascular resistance (PVR) in persistent pulmonary hypertension of the newborn (PPHN).
Mechanism of Action
Vasodilation by means of a direct effect on peripheral vascular smooth muscle and indirect effects produced, in part, by release of endogenous histamine; tolazoline has moderate alpha-adrenergic blocking activity and has histamine agonist activity. Tolazoline usually reduces pulmonary arterial pressure and vascular resistance.
MeSH Pharmacological Classification
Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
Drugs used to cause dilation of the blood vessels.
Cellular LocationsMembrane
Anwendungen
VerwendenTolazoline is used for treating stable forms of pulmonary hypertension in newborns, and in cases where systemic arterial oxygenation cannot be achieved in the usual manner under careful observation of professionals.
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