Grundinformationen
- CAS
1405-20-5- Standard-SMILES
CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(Cc2ccccc2)NC(=O)C(CCN)NC1=O)C(C)O.O=S(=O)(O)O- InChIKey
HFMDLUQUEXNBOP-UHFFFAOYSA-N- Summenformel
- C56H100N16O17S
- Durchschnittliche Molmasse
- 1.301,6 g/mol
Überblick
Polymyxin B sulphate is a cyclic peptide.
Namen und Bezeichner
- Bevorzugter Name
- Aerosporin
- IUPAC
- N-[4-amino-1-[[1-[[4-amino-1-oxo-1-[[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methyloctanamide;sulfuric acid
- Lokaler Name
- Polymyxin B, Sulfat (Salz)
- Englischer Name
- Polymyxin B sulfate
- Summenformel
- C56H100N16O17S
- Molmasse
- 1301.56
Namen und Synonyme
AerosporinMFCD00131991N-[4-amino-1-[[1-[[4-amino-1-oxo-1-[[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methyloctanamide;sulfuric acidSR-05000002074sufuric acidC56H100N16O17SNCGC00094763-01Polymyxin B sulfate CRSSPECTRUM1500492orb1226347Polymyxin B sulfate salt powderHMS502E14
Weitere Namen anzeigen
POLYMYXIN BPOLYMYXIN B SULPHATEPOLYMIXIN B SULFATEPOLYMIXIN B SULPHATEpolymyxin B sulfate uspPolymyxin B sulfate for microbiological assayN-[3-AMino-1-[[1-[[3-aMino-1-[[6,9,18-tris(2-aMinoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-Methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]carbaMoyl]propyl]carbaMoyl]-2-hydroxy-propyl]carbaMoyl]pro
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 574 Ų
- H-Brücken-Donoren
- 20
- H-Brücken-Akzeptoren
- 22
- Frei drehbare Bindungen
- 29
- Schwere Atome
- 90
- Formalladung
- 0
- Komplexität
- 2.240
Physikochemische Eigenschaften
- Schmelzpunkt
- 217 · 217-220°C (dec.)
- storage temp.
- 2 · 2-8°C
- Löslichkeit
- 2 O: · H2O: 50 mg/mL
- pka
- 8.9 · pKa 8.9 (Uncertain)
- Aggregatzustand
- powder
- Farbe
- colorless or slightly yellow
- PH
- pH (10g/L, 25℃) : 4.5～7.0
- Biologische Quelle
- Pseudomonas aeruginosa
- Wasserlöslichkeit
- 50 mg/ml/n · Soluble in water at 50mg/ml/n
- Merck
- 14 · 14,7573
- Stabilität
- Hygroscopic
- InChIKey
- HFMDLUQUEXNBOP-UHFFFAOYSA-N
- LogP
- -6.361 · -6.361 (est)
- CAS Datenbank
- 1405 · 1405-20-5(CAS DataBase Reference)
- EPA chemische Informationen
- Polymixin B sulfate (1405-20-5)
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- F
- 3-8-10
- wgk
- 3
- ridadr
- 3249
- hs_code
- 2941 90 00
- RTECS-Nr.
- TR1150000
- risk_code
- 22
- Toxizität
- dog,LDLo,intracrebral,320ug/kg (0.32mg/kg),BEHAVIORAL: COMA,British Journal of Pharmacology and Chemotherapy. Vol. 23, Pg. 552, 1964.
- hazard_code
- Xn
- safety_code
- 22-24/25
- hazard_class
- 6.1(b)
- packing_group
- III
- Speicherklasse
- 11 - Combustible Solids
- Hazard Classifications
- Acute Tox. 4 Oral
Chemie und Industrie
Anwendungen
BeschreibungThe polymyxins are cationic peptides originally isolated from B. polymyxa. They bind and kill Gram-negative bacteria. The B series of polymyxins consist of a cyclic heptapeptide and a tripeptide side chain acylated at the amino terminus by a fatty acid. Polymyxin B (sulfate) is a mixture of at least four closely related components, polymyxin B1 to B4, with polymyxin B1 and B2 being the two major components. Polymyxin B (sulfate) has rapid in vitro bactericidal activity against major multidrug-resistant Gram-negative bacteria, such as P. aeruginosa, A. baumannii, and K. pneumoniae.
VerwendenPolymyxin B sulfate is used as topical antibiotic agent, often used in combination with neomycin; products include ointments, creams, eye, and ear drops.
Anbieter100 Anbieter
国药集团化学试剂有限公司86-21-63210123 · [email protected]
北京华美互利生物化工010-56205725 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
湖北威德利化学试剂有限公司186-02735115 18062128043 · [email protected]
北京安司莫森技术有限公司010-82954736 13391601435 · [email protected]
LGM Pharma1-(800)-881-8210 · [email protected]
上海将来实业股份有限公司400-0066400 13621662912 · [email protected]
上海迈瑞尔生化科技有限公司
Zugehörige Reaktionen
5
Notizen zur Verbindung
Wird geladen…