Lithiumbis(trimethylsilyl)amid

Lithium bis(trimethylsilyl)amide

HCID 57426343CAS 4039-32-1
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Grundinformationen

Standard-SMILES
C[Si](C)(C)N[Si](C)(C)C.[Li]
InChIKey
QQIRAVWVGBTHMJ-UHFFFAOYSA-N
Summenformel
C6H19LiNSi2
Durchschnittliche Molmasse
168,4 g/mol

Überblick

structure in first source

Namen und Bezeichner

Bevorzugter Name
Lithium bis(trimethylsilyl)amide
Lokaler Name
Lithiumbis(trimethylsilyl)amid
Englischer Name
Lithium bis(trimethylsilyl)amide
Summenformel
C6H18LiNSi2
Molmasse
167.33

Namen und Synonyme

Bis(trimethylsilyl)amidolithiumLithiumbis(trimethylsilyl)amineBis(trimethylsilyl)amido lithiumLi bis(TMS)ARefChem:924827(LiN(SiMe3)2)223-725-64039-32-1Disilazane, 1,1,1,3,3,3-hexamethyl-, lithium saltLithium bis(trimethylsilyl)amideLithium, (bis(trimethylsilyl)amino)-Lithiumbis(trimethylsilyl)amide
Weitere Namen anzeigen
LIHMDSLHMDSLiHDMSLITHIUM HEXAMETHYLDISILAZANELithium 1,1,1,3,3,3-hexamethyldisilazideLITHIUM HEXAMETHYLDISILAZIDELithium bis(trimethylsilyl)amide solutionLiHMDS（1M）HMDS LiLiHMDS 1M in THF
lithium bis(trimethylsilyl)aminelithium HMDSlithiumhexamethyldisilazanelithium hexamethydisilazanelithium hexamethyidisilazanelithium hexamethyl disilazanelithium hexamethyl-disilazanelithium(hexamethyldisilazane)

Datenbank-Bezeichner

CAS
4039-32-1
PubChem CID
57426343
EC Number
223-725-6

Eigenschaften

Berechnete Struktureigenschaften

Polarare Oberfläche (TPSA)
12 Ų
H-Brücken-Donoren
1
H-Brücken-Akzeptoren
1
Frei drehbare Bindungen
2
Schwere Atome
10

Experimentelle und physikochemische Eigenschaften

Chemical ClassesMetals -> Metalloid Compounds (Silicon)
Physical Description · 2 Einträge

Wet Solid

White powder; [Alfa Aesar MSDS]

Physikochemische Eigenschaften

Schmelzpunkt
73 °C · 73°C
Siedepunkt
55 · 55-56 °C
Dichte
0.86 g/mL · 0.860 g/mL at 25 °C (lit.)
Brechungsindex
20 · n20/D 1.425(lit.)
Flammpunkt
48 °F · 48 °F
storage temp.
30 °C · Store below +30°C.

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 4 Einträge

Danger

H228 (43.9%): Flammable solid [Danger Flammable solids]

P210, P240, P241, P260, P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P330, P362+P364, P363, P370+P378, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 198 reports by companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Gefahrenhinweise

Regulatory Information · 3 Einträge

Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-, lithium salt (1:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-, lithium salt (1:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 19-10-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/13861

1,1,1,3,3,3-Hexamethyldisilazane lithium salt: Does not have an individual approval but may be used under an appropriate group standard

Hazards SummaryReacts violently with water evolving extremely flammable gases; Causes burns; [Alfa Aesar MSDS] See Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-, hydrolysis products with silica. See Hexamethyldisilazane. See Lithium.
Hazard Classes and CategoriesFlam. Sol. 2 (43.9%)

Toxikologische Informationen

Adverse EffectsDermatotoxin - Skin burns.

Sicherheitsdaten

F
10-23
wgk
3
tsca
TSCA listed
ridadr
UN 2925 4.1/PG 2
hs_code
29319090
risk_code
11-34-48/20-63-65-67-51/53-35-20-62-14-40-37-19

Chemie und Industrie

Verwendung und Herstellung

UsesUsed as an intermediate; [ExPub: ECHA REACH Registrations]
U.S. Production2023: <50,000 lb
Industry UsesIntermediate
General Manufacturing Information · 2 Einträge

Pharmaceutical and Medicine Manufacturing

Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-, lithium salt (1:1): ACTIVE

Anwendungen · 1 Eintrag

VerwendenLithium bis(trimethylsilyl)amide is used as nonnucleophilic base to generate kinetic ketone and ester enolates. It is considerably more selective than LDA and undesired reductions (e.g., of nonenolizable ketones observed in the case of LDA) can be avoided by using LHMDS.

Darstellung

synthetischeIt is conveniently prepared by the reaction of hexamethyldisilazane with n-butyllithium in hexane. For most uses the hexane is then evaporated and replaced with THF.

Vor- und nachgelagerte Produkte

Anbieter50 Anbieter

国药集团化学试剂有限公司86-21-63210123 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
四川伟博贸易有限公司028-65199188 13880582998 · [email protected]
T&W GROUP021-61551611 13296011611 · [email protected]

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