Zofran (HCID 59774)｜Huagongshe

Überblick

Ondansetron hydrochloride is a member of carbazoles.

Namen und Bezeichner

Bevorzugter Name: Zofran
IUPAC: 9-methyl-3-[(2-methylimidazol-1-yl)methyl]-2,3-dihydro-1H-carbazol-4-one;dihydrate;hydrochloride
Englischer Name: Ondansetron hydrochloride
Summenformel: C18H22ClN3O2
Molmasse: 347.84

Namen und Synonyme

ZofranRefChem:934563Ondansetron hydrochloride dihydrate103639-04-9Ondansetron hydrochloride hydrateSetrodonDTXSID90488579-methyl-3-[(2-methylimidazol-1-yl)methyl]-2,3-dihydro-1H-carbazol-4-one;dihydrate;hydrochlorideGR-38032FMFCD00374371CHEBI:7774DTXCID6028783

Weitere Namen anzeigen

AKOS NCG1-0013ondansetron hydOndansetronHclUsp28Ondansetron hydrochlODANSETRON HYDROCHLORIDEOndansetron hydrochloridOndansetronHClmonohydrateOndansetron hydrochlorideGR 38032SN 307NSC 665799Ondansetron impurity A CRS

Ondansetron (hydrochloride dihydrate)9-Methyl-3-((2-methyl-1H-imidazol-1-yl)methyl)-1,2,3,9-tetrahydro-4H-carbazol-4-one hydrochloride dihydrateKS-1091ONDANSETRON HYDROCHLORIDE [MART.]CAS-103639-04-94H-Carbazol-4-one,1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-,monohydrochloride, dihydrateUNII-NMH84OZK2BZensana

Datenbank-Bezeichner

CAS: 103639-04-9
PubChem CID: 59774
DTXSID: DTXSID9048857
ChEBI: CHEBI:7774
UNII: NMH84OZK2B
EC Number: 600-465-5

Eigenschaften

Berechnete Struktureigenschaften

Polarare Oberfläche (TPSA): 41,8 Å²
H-Brücken-Donoren: 3
H-Brücken-Akzeptoren: 4
Frei drehbare Bindungen: 2
Schwere Atome: 25
Formalladung: 0
Komplexität: 440

Experimentelle und physikochemische Eigenschaften

Human DrugsBreast Feeding; Lactation; Milk, Human; Antiemetics; Gastrointestinal Agents; Serotonin Antagonists; Serotonin 5-HT3 Receptor Antagonists

Physikochemische Eigenschaften

Schmelzpunkt: 231 · 231-232 C
storage temp.: -20 °C · -20°C
Löslichkeit: 2 O: · H2O: >5mg/mL
Aggregatzustand: powder
Farbe: white
Wasserlöslichkeit: 2 O: · H2O: >5mg/mL
InChI: InChI=1S/C18H19N3O.ClH.H2O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2;;/h3-6,9-10,13H,7-8,11H2,1-2H3;1H;1H2
InChIKey: FELGMEQIXOGIFQ-ZDUSSCGKSA-N
SMILES: O=C1C(CCC2N(C)C3=CC=CC=C3C1=2)CN1C=CN=C1C.Cl.O
CAS Datenbank: 103639 · 103639-04-9(CAS DataBase Reference)

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 4 Einträge

Danger

H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]

P264, P264+P265, P270, P273, P280, P301+P316, P305+P351+P338, P305+P354+P338, P317, P321, P330, P337+P317, P391, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 117 reports by companies from 16 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Gefahrenhinweise

Hazard Classes and CategoriesAcute Tox. 3 (100%)

Toxikologische Informationen

TreatmentThere is no specific antidote for ondansetron overdose. Patients should be managed with appropriate supportive therapy. (L1712)

Exposure RoutesOndansetron is well absorbed after oral administration and undergoes limited first-pass metabolism.

Toxicity Summary · 1 Eintrag

Ondansetron is a selective serotonin 5-HT3 receptor antagonist. The antiemetic activity of the drug is brought about through the inhibition of 5-HT3 receptors present both centrally (medullary chemoreceptor zone) and peripherally (GI tract). This inhibition of 5-HT3 receptors in turn inhibits the visceral afferent stimulation of the vomiting center, likely indirectly at the level of the area postrema, as well as through direct inhibition of serotonin activity within the area postrema and the chemoreceptor trigger zone.

Signs and SymptomsLow blood pressure and fainting, sudden blindness, severe constipation

Carcinogen ClassificationNo indication of carcinogenicity to humans (not listed by IARC).

Effects During Pregnancy and Lactation◉ Summary of Use during Lactation

Sicherheitsdaten

wgk: 3
ridadr: UN 2811
hs_code: 2933290000
RTECS-Nr.: FE6375500
risk_code: 25-36/37/38-50/53-41
hazard_code: T,Xi
safety_code: 45-37/39-26-61-39
hazard_class: 6.1
packing_group: III
Speicherklasse: 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
Hazard Classifications: Acute Tox. 3 OralAquatic Acute 1Aquatic Chronic 2Eye Dam. 1

Chemie und Industrie

Pharmakologische Informationen

Metabolism/MetabolitesHepatic Half Life: 5.7 hours

MeSH Pharmacological Classification · 3 Einträge

Drugs used to prevent NAUSEA or VOMITING.

Agents, usually topical, that relieve itching (pruritus).

Drugs that bind to but do not activate SEROTONIN 5-HT3 RECEPTORS, thereby blocking the actions of SEROTONIN or SEROTONIN 5-HT3 RECEPTOR AGONISTS.

Verwendung und Herstellung

UsesFor the prevention of nausea and vomiting associated with emetogenic cancer chemotherapy, postoperation, and radiation. Also used for the treatment of postoperative nausea and vomiting.

Anwendungen · 2 Einträge

BeschreibungOndansetron hydrochloride is a selective 5HT3-antagonist approved for the management of nausea and vomiting induced by cancer chemotherapy and radiotherapy. It is reported to have a superior side-effect profile compared with metoclopramide, representing an important advance in the treatment of nausea and vomiting associated with chemotherapy. Ondansetron hydrochloride is the first specific 5HT3-antagonist to reach the market. It is also under investigation for a number of other indications, including anxiety and schizophrenia.

VerwendenOndansetron hydrochloride dihydrate has been used as a 5-HT3 antagonist to attenuate rostro ventromedial medulla (RVM)/cholecystokinin (CCK)-induced mechanical hypersensitivity and to block the effects of trichostatin A (TSA) on 5-HT3 protein.