Hydrochloric Acid → Zofran

HRID 642923

Reaktionsgleichung

Reaktionsgleichung von HRID 642923
[CH3:1][C:2]1[N:6]([CH2:7][CH:8]2[C:21](=[O:22])[C:12]3[C:13]4[CH:14]=[CH:15][CH:16]=[CH:17][C:18]=4[N:19]([CH3:20])[C:11]=3[CH2:10][CH2:9]2)[CH:5]=[CH:4][N:3]=1.[ClH:23]>C(O)(C)C.O>[CH3:1][C:2]1[N:6]([CH2:7][CH:8]2[C:21](=[O:22])[C:12]3[C:13]4[C:18]([N:19]([CH3:20])[C:11]=3[CH2:10][CH2:9]2)=[CH:17][CH:16]=[CH:15][CH:14]=4)[CH:5]=[CH:4][N:3]=1.[OH2:22].[OH2:22].[ClH:23]

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 4595Ondansetron

Produkt 1

HCID 59774ZofranAusbeute 49 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

The crude ondansetron from Example 4 (190 grams; 0.65 mol) was suspended in a mixture of isopropanol (1.2 L) and water (0.24 L). Concentrated hydrochloric acid (32% (w/w)) was added until the pH of the mixture was about 1-2 (about 70 mL). The solution was heated to reflux temperature for one hour and then cooled to room temperature. The precipitated crystals were collected by filtration, and dried to provide 117 grams (0.32 mol; 49% yield) of crude ondansetron hydrochloride dihydrate. The purity was determined to be about 98-99% by HPLC.

Aufarbeitung

  1. temperatureThe solution was heated
  2. temperatureto reflux temperature for one hour
  3. filtrationThe precipitated crystals were collected by filtration
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-0310217a65cb45f193e82b9f3ceb3ced
Quelldatensatz
uspto-grants-2010_04
Patentnummer
US07696356B2

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