Grundinformationen
- CAS
58-60-6- Standard-SMILES
CN(C)c1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](N)[C@H]1O- InChIKey
RYSMHWILUNYBFW-GRIPGOBMSA-N- Summenformel
- C12H18N6O3
- Durchschnittliche Molmasse
- 294,31 g/mol
- Monoisotopische Masse
- 294,14403846
Überblick
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine is puromycin derivative that lacks the methoxyphenylalanyl group on the amine of the sugar ring. It is a member of adenosines and a 3'-deoxyribonucleoside.
Namen und Bezeichner
- Bevorzugter Name
- Aminonucleoside
- IUPAC
- (2R,3R,4S,5S)-4-amino-2-[6-(dimethylamino)purin-9-yl]-5-(hydroxymethyl)oxolan-3-ol
- Lokaler Name
- 3'-Amino-3'-desoxy-N,N-dimethyladenosin
- Englischer Name
- Puromycin aminonucleoside
- Summenformel
- C12H18N6O3
- Molmasse
- 294.31
Namen und Synonyme
Puromycin aminonucleoside58-60-6AminonucleosideStylomycin aminonucleoside3'-amino-3'-deoxy-n6,n6-dimethyladenosine6-Dimethylamino-9-(3'-ribosylamine)purineAminonucleoside, PuromycinDTXSID70372640Q580U88V83' Amino 3' deoxy N,N dimethyladenosineNSC-3056RefChem:177305
Weitere Namen anzeigen
ARDMANsc3056Aids000507Aids-0005073′-Amino-3′-deoxy-N63’-Amino-3’-deoxy-N6aminonucleosidepuromycinPuroMycin aMinonucleosidstylomycinaminonucleoside
DTXCID5017264200-388-33'-Amino-3'-deoxy-N,N-dimethyladenosineADENOSINE, 3'-AMINO-3'-DEOXY-N,N-DIMETHYL-MFCD00063462Puromycin Impurity 13'-amino-3'-deoxy-n(6),n(6)-dimethyladenosineC12H18N6O3
Datenbank-Bezeichner
- CAS
58-60-6
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- -0,5
- Polarare Oberfläche (TPSA)
- 123 Ų
- H-Brücken-Donoren
- 3
- H-Brücken-Akzeptoren
- 8
- Frei drehbare Bindungen
- 3
- Schwere Atome
- 21
- Formalladung
- 0
- Komplexität
- 373
Physikochemische Eigenschaften
- Schmelzpunkt
- 235 ℃ · 235℃ (Decomposition)
- Siedepunkt
- 436.08 °C · 436.08°C (rough estimate)
- Dichte
- 1.2131 · 1.2131 (rough estimate)
- Brechungsindex
- 1.7 · 1.7000 (estimate)
- Flammpunkt
- 110 ° · >110°(230°F)
- storage temp.
- 2 · Keep in dark place,Inert atmosphere,2-8°C
- Löslichkeit
- 2 O: · H2O: 50 mg/mL, clear, slightly yellow
- Aggregatzustand
- liquid
- pka
- 13.26 · 13.26±0.70(Predicted)
- Farbe
- White
- Wasserlöslichkeit
- 50 mg/ml · Soluble in water at 50mg/ml. May require heating
- BRN
- 93902 · 93902
- Stabilität
- 1 year · Stable for 1 year as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 2 months.
- InChI
- 1S/C12H18N6O3/c1-17(2)10-8-11(15-4-14-10)18(5-16-8)12-9(20)7(13)6(3-19)21-12/h4-7,9,12,19-20H,3,13H2,1-2H3/t6-,7+,9+,12-/m1/s1
Sicherheit und Regulatorisches
GHS-Klassifizierung
GHS Classification
Warning
H373 (97.8%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]
P260, P319, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 46 reports by companies from 4 notifications to the ECHA C&L Inventory.
Gefahrenhinweise
Hazard Classes and CategoriesSTOT RE 2 (97.8%)
Sicherheitsdaten
- F
- 10-21
- wgk
- 3
- tsca
- TSCA listed
- hs_code
- 29419090
- RTECS-Nr.
- AU7337000
- risk_code
- 48/22
- hazard_code
- Xi,Xn
- Speicherklasse
- 11 - Combustible Solids
- Hazard Classifications
- STOT RE 2
Chemie und Industrie
Pharmakologische Informationen
MeSH Pharmacological Classification
Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms.
Antimetabolites that are useful in cancer chemotherapy.
Verwendung und Herstellung
General Manufacturing InformationAdenosine, 3'-amino-3'-deoxy-N,N-dimethyl-: INACTIVE
Anwendungen
VerwendenPuromycin aminonucleoside is a semi-synthetic derivative of puromycin which lacks the methoxyphenylalanyl moiety. Puromycin aminonucleoside is the key intermediate in the synthesis of semi-synthetic analogues of puromycin. It does not inhibit protein synthesis or induce apoptosis, but exhibits antitumour properties. Puromycin aminonucleoside-induced nephrosis is a well-described model of human idiopathic nephrotic syndrome, suppressing integrin expression in cultured glomerular epithelial cells.
Vor- und nachgelagerte Produkte
Vorgelagerte Rohstoffe
Anbieter100 Anbieter
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
湖北万得化工有限公司15377098680 15377098680 · [email protected]
武汉英诺医药科技有限公司
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