HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
3'-Amino-3'-desoxy-N,N-dimethyladenosin
ARDMA · Nsc3056 · Aids000507 · Aids-000507 · aminonucleoside · 3′-Amino-3′-deoxy-N6 · 3’-Amino-3’-deoxy-N6 · aminonucleosidepuromycin
Identifikatoren & physikalische Daten
| CAS No. | 58-60-6 |
|---|---|
| Summenformel | C12H18N6O3 |
| Durchschnittliche Molmasse | 294,31 g/mol |
| Monoisotopische Masse | 294,14403846 g/mol |
| SMILES | CN(C)c1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](N)[C@H]1O |
| InChIKey | RYSMHWILUNYBFW-GRIPGOBMSA-N |
| PubChem CID | 6020 |
| ChEMBL | CHEMBL1233071 |
| ChEBI | CHEBI:42839 |
| EC No. | 200-388-3 |
| DTXSID | DTXSID7037264 |
| Lokaler Name | 3'-Amino-3'-desoxy-N,N-dimethyladenosin |
Chemische & physikalische Eigenschaften
| XLogP | -0,5 |
|---|---|
| Polarare Oberfläche (TPSA) | 123 |
| H-Brücken-Donoren | 3 |
| H-Brücken-Akzeptoren | 8 |
| Frei drehbare Bindungen | 3 |
| Schwere Atome | 21 |
| Formalladung | 0 |
| Komplexität | 373 |
| Schmelzpunkt | 235℃ (Decomposition) |
| Siedepunkt | 436.08°C (rough estimate) |
| Dichte | 1.2131 (rough estimate) |
| Brechungsindex | 1.7000 (estimate) |
| Flammpunkt | >110°(230°F) |
| Lagerbedingungen | Keep in dark place,Inert atmosphere,2-8°C |
| Löslichkeit | H2O: 50 mg/mL, clear, slightly yellowSoluble in water at 50mg/ml. May require heating |
| Aggregatzustand | liquid |
| pKa (Säurekonstante) | 13.26±0.70(Predicted) |
| Farbe | White |
| BRN | 93902 |
| Stabilität | Stable for 1 year as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 2 months. |
| InChI | 1S/C12H18N6O3/c1-17(2)10-8-11(15-4-14-10)18(5-16-8)12-9(20)7(13)6(3-19)21-12/h4-7,9,12,19-20H,3,13H2,1-2H3/t6-,7+,9+,12-/m1/s1 |
| InChIKey | RYSMHWILUNYBFW-GRIPGOBMSA-N |
| SMILES | CN(C)c1ncnc2n(cnc12)[C@@H]3O[C@H](CO)[C@H](N)[C@@H]3O |
| EPA chemische Informationen | Adenosine, 3'-amino-3'-deoxy-N,N-dimethyl- (58-60-6) |
Sicherheit & Vorschriften
| GHS-Einstufung | WarningH373 (97.8%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]P260, P319, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 46 reports by companies from 4 notifications to the ECHA C&L Inventory. |
|---|---|
| Hazard Classes and Categories | STOT RE 2 (97.8%) |
| F | 10-21 |
| Wassergefährdungsklasse (WGK) | 3 |
| TSCA-Inventar-Status | TSCA listed |
| Zollcode | 29419090 |
| RTECS-Nr. | AU7337000 |
| R-Sätze (R) | 48/22 |
| Gefahrensymbole | Xi,Xn |
| Lagerklasse | 11 - Combustible Solids |
| Gefahrenklasse | STOT RE 2 |
Anwendungen & Verwendung
Verwenden
Puromycin aminonucleoside is a semi-synthetic derivative of puromycin which lacks the methoxyphenylalanyl moiety. Puromycin aminonucleoside is the key intermediate in the synthesis of semi-synthetic analogues of puromycin. It does not inhibit protein synthesis or induce apoptosis, but exhibits antitumour properties. Puromycin aminonucleoside-induced nephrosis is a well-described model of human idiopathic nephrotic syndrome, suppressing integrin expression in cultured glomerular epithelial cells.