Phenelzine Sulfate (HCID 61100)

Namen und Bezeichner

Bevorzugter Name: Phenelzine Sulfate
IUPAC: 2-phenylethylhydrazine;sulfuric acid
Lokaler Name: (2-Phenylethyl)hydrazin-sulfat(1:1)
Englischer Name: Phenelzine Sulfate
Summenformel: C8H14N2O4S
Molmasse: 234.27

Namen und Synonyme

Phenelzine sulfate156-51-4Phenelzine sulphatePhenelzine acid sulfateHydrazine, (2-phenylethyl)-, sulfate (1:1)Phenethylhydrazine sulfate (1:1)2-Phenylethylhydrazine sulphateNSC-1709572-Phenylethylhydrazine hydrogen sulphatePhenelzine sulfate (USP)Phenelzine sulfate [USP]2681D7P965

Weitere Namen anzeigen

Phenelzine Sulfate (1517006)wl7p1531ep-411alazinkalganS-1544alacine

NSC170957Sulfate, PhenelzineRefChem:55843205-856-0AlazinePHENELZINE SULFATE SALTPhenethylhydrazine sulfateEstinerval

Datenbank-Bezeichner

CAS: 156-51-4
PubChem CID: 61100
DTXSID: DTXSID3021144
ChEMBL: CHEMBL1200895
ChEBI: CHEBI:8061
UNII: 2681D7P965
EC Number: 205-856-0

Eigenschaften

Berechnete Struktureigenschaften

Polarare Oberfläche (TPSA): 121 Å²
H-Brücken-Donoren: 4
H-Brücken-Akzeptoren: 6
Frei drehbare Bindungen: 3
Schwere Atome: 15
Formalladung: 0
Komplexität: 159

Physikochemische Eigenschaften

Schmelzpunkt: 166.5 · 166.5-167.5 °C
storage temp.: 2 · 2-8°C
Löslichkeit: Freely soluble in water; practically insoluble in ethanol (96%) and in ether .
Aggregatzustand: A solid
Farbe: White to off-white
Biologische Quelle: synthetic
Wasserlöslichkeit: 50 mg/mL, · water: 50mg/mL, clear to slightly hazy, colorless to faintly yellow
Merck: 13 · 13,7300
Major Application: pharmaceutical (small molecule)
InChI: InChI=1S/C8H12N2.H2O4S/c9-10-7-6-8-4-2-1-3-5-8;1-5(2,3)4/h1-5,10H,6-7,9H2;(H2,1,2,3,4)
InChIKey: RXBKMJIPNDOHFR-UHFFFAOYSA-N
SMILES: C1(CCNN)C=CC=CC=1.S(=O)(=O)(O)O
CAS Datenbank: 156 · 156-51-4

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 5 Einträge

Danger

H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]

P264, P270, P301+P316, P321, P330, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 39 reports by companies from 1 notifications to the ECHA C&L Inventory.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Gefahrenhinweise

Other Safety InformationIMAP assessments - Hydrazine, (2-phenylethyl)-, sulfate (1:1): Human health tier I assessment；IMAP assessments - Hydrazine, (2-phenylethyl)-, sulfate (1:1): Environment tier I assessment

Hazard Classes and CategoriesAcute Tox. 3 (100%)

Toxikologische Informationen

Carcinogen Classification · 5 Einträge

Phenelzine sulfate

Group 3: Not classifiable as to its carcinogenicity to humans

Volume 24: (1980) Some Pharmaceutical Drugs；Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print)

1987

Drug Induced Liver Injury · 6 Einträge

Drug Induced Liver Injury Rank (DILIrank 2.0)

Phenelzine sulfate

vLess-DILI-concern

3

Adverse reactions

DOI:10.1016/j.drudis.2016.02.015

Sicherheitsdaten

wgk: 3
ridadr: UN 2811 6.1/PG 3
hs_code: 2928002500
RTECS-Nr.: MV8750000
risk_code: 22
Toxizität: LD50 orally in mice: 156 mg/kg (Gylys)
hazard_code: Xn
hazard_class: 6.1(b)
packing_group: III
Speicherklasse: 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
Hazard Classifications: Acute Tox. 3 Oral

Chemie und Industrie

Pharmakologische Informationen

FDA Pharmacological Classification · 2 Einträge

PHENELZINE SULFATE

Monoamine Oxidase Inhibitors [MoA]; Monoamine Oxidase Inhibitor [EPC]

MeSH Pharmacological Classification · 2 Einträge

Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems.

A chemically heterogeneous group of drugs that have in common the ability to block oxidative deamination of naturally occurring monoamines. (From Gilman, et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p414)

Anwendungen · 1 Eintrag

VerwendenPhenelzine Sulfate is a hydrazine derivative that is a non-selective and irreversible monoamine oxidase inhibitor (MAOI) and also inhibits GABA-transaminase (GABA-T), markedly increasing brain GABA levels. It is an antidep ressant and anxiolytic used in the treatment of major depressive disorder (MDD) as well as other neural disorders.