DL-Serin
DL-Serine
Grundinformationen
- CAS
302-84-1- Standard-SMILES
NC(CO)C(=O)O- InChIKey
MTCFGRXMJLQNBG-UHFFFAOYSA-N- Summenformel
- C3H7NO3
- Durchschnittliche Molmasse
- 105,09 g/mol
- Monoisotopische Masse
- 105,04259309
Überblick
Serine is an alpha-amino acid that is alanine substituted at position 3 by a hydroxy group. It has a role as a fundamental metabolite. It is a polar amino acid and an alpha-amino acid. It contains a hydroxymethyl group. It is a conjugate base of a serinium. It is a conjugate acid of a serinate. It is a tautomer of a serine zwitterion.
Namen und Bezeichner
- Bevorzugter Name
- DL-Serine
- IUPAC
- 2-amino-3-hydroxypropanoic acid
- Lokaler Name
- DL-Serin
- Englischer Name
- DL-Serine
- Summenformel
- C3H7NO3
- Molmasse
- 105.09
Namen und Synonyme
DL-Serine302-84-1Serine, DL-00PAR1C66FNSC-9960DTXSID70859325NSC9960Serine DL-RefChem:1083916DTXCID20202802206-130-62-azaniumyl-3-hydroxypropanoate
Weitere Namen anzeigen
SERINEserinDL-SER2-AMINO-3-HYDROXY-PROPIONIC ACIDDL-SerinDL-Ser-OHDL-SERINE,FCC
2-Amino-3-hydroxypropanoic acidSerine DL-formH-DL-Ser-OHSERINE, (L)L-Serine-2-13c-15Nd,l-serineDL-2-Amino-3-hydroxypropionic AcidDL-SERINE (1-13C)
Datenbank-Bezeichner
- CAS
302-84-1、312-84-5、56-45-1- PubChem CID
- 617
- DTXSID
DTXSID70859325- ChEBI
CHEBI:17822- UNII
- 00PAR1C66F
- EC Number
- 206-130-6
- Nikkaji
- J1.277G
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- -3,1
- Polarare Oberfläche (TPSA)
- 83,6 Ų
- H-Brücken-Donoren
- 3
- H-Brücken-Akzeptoren
- 4
- Frei drehbare Bindungen
- 2
- Schwere Atome
- 7
- Formalladung
- 0
- Komplexität
- 72,6
Experimentelle und physikochemische Eigenschaften
Chemical ClassesBiological Agents -> Amino Acids and Derivatives
LipidsFatty Acyls [FA] -> Fatty Acids and Conjugates [FA01] -> Amino fatty acids [FA0110]
Flavoring AgentsEU Flavoring substances
Physical DescriptionSolid; [Merck Index] Beige crystalline solid; [Sigma-Aldrich MSDS]
Physikochemische Eigenschaften
- Schmelzpunkt
- 240 °C · 240 °C (dec.) (lit.)
- Siedepunkt
- 197.09 °C · 197.09°C (rough estimate)
- Dichte
- 1.53 · 1.53
- Brechungsindex
- 1.4368 · 1.4368 (estimate)
- storage temp.
- 30 °C · Store below +30°C.
- Löslichkeit
- 2 O: · H2O: soluble
- Aggregatzustand
- Crystalline Powder
- pka
- 2.19 · 2.19(at 25℃)
- Farbe
- White
- Geruch (Odor)
- Odorless
- Wasserlöslichkeit
- 50.23 g/L · 50.23 g/L (25 ºC)
- Merck
- 14 · 14,8460
- BRN
- 1721402 · 1721402
- Henry's Law Constant
- 3.9 · 3.9×1010 mol/(m3Pa) at 25℃, Saxena and Hildemann (1996)
- Kosmetik-Inhaltsstoffe Funktionen
- FRAGRANCEHAIR CONDITIONINGANTISTATICSKIN CONDITIONING
- InChI
- 1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)
- InChIKey
- MTCFGRXMJLQNBG-UHFFFAOYSA-N
- SMILES
- NC(CO)C(O)=O
- LogP
- -3.46 · -3.460
- CAS Datenbank
- 302 · 302-84-1(CAS DataBase Reference)
- NIST chemische Informationen
- DL-Serine(302-84-1)
- EPA chemische Informationen
- Serine (302-84-1)
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
This chemical does not meet GHS hazard criteria for 99.6% (261 of 262) of all reports.
Not Classified
Aggregated GHS information provided per 262 reports by companies from 2 notifications to the ECHA C&L Inventory.
Gefahrenhinweise
Regulatory Information
Chemical: DL-Serine
Regulation (EC) No 1831/2003 (amended)
REACH registered substance: DL-serine (EC: 206-130-6)
Serine: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationIMAP assessments - DL-Serine: Environment tier I assessment
Hazards SummaryMay cause irritation; [Sigma-Aldrich MSDS] See L-Serine.
Hazard Classes and CategoriesNot Classified
Sicherheitsdaten
- wgk
- 3
- tsca
- TSCA listed
- hs_code
- 29225000
- RTECS-Nr.
- VT8100000
- risk_code
- 36/37/38
- hazard_code
- Xi
- safety_code
- 24/25-36-26
- Speicherklasse
- 11 - Combustible Solids
Chemie und Industrie
Verwendung und Herstellung
UsesA non-essential amino acid; [Merck Index]
General Manufacturing InformationSerine: ACTIVE
Anwendungen
BeschreibungDL-Serine is a kind of neutral aliphatic amino acids containing hydroxyl groups with polarity but being uncharged, and belongs to nonessential amino acids for human body. It has a high content in sericin silk protein and fibroin protein. It can be formed from the methyl transfer reaction of glycine. It can also be converted to pyruvate or hydroxy pyruvate through deamination. It is also an important raw material for in vivo synthesis of choline and cysteine.
VerwendenDL-Serine is used in the synthesis of novel tryptoline derivatives as IDO (indoleamine 2,3-Deoxygenase) inhibitors, for potential use in Alzheimer’s treatment.
Darstellung
synthetischeDL-serine is obtained by complexing glycine under the catalysis of copper ions and then combining with formaldehyde under alkaline conditions, followed by acidification, ion exchange, and crystallization in ethanol.
Vor- und nachgelagerte Produkte
Vorgelagerte Rohstoffe
Nachgelagerte Produkte
Ergänzende Hinweise
DefinitionChEBI: Serine is an alpha-amino acid that is alanine substituted at position 3 by a hydroxy group. It has a role as a fundamental metabolite. It is an alpha-amino acid and a polar amino acid. It contains a hydroxymethyl group. It is a conjugate base of a serinium. It is a conjugate acid of a serinate. It is a tautomer of a serine zwitterion.
Zugehörige Reaktionen
44
Notizen zur Verbindung
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