Trisodium citrate

Metals -> Organic Acids, Metal Salts

Metals -> Organic Acids, Metal Salts

Cosmetic ingredients (Sodium Citrate) -> CIR (Cosmetic Ingredient Review)

Buffering; Chelating

COLOR OR COLORING ADJUNCT, EMULSIFIER OR EMULSIFIER SALT, FLAVORING AGENT OR ADJUVANT, MALTING OR FERMENTING AID, NUTRIENT SUPPLEMENT, PH CONTROL AGENT, SEQUESTRANT, STABILIZER OR THICKENER, SURFACE-ACTIVE AGENT -> FDA Substance added to food

29.4g/L

White, odorless crystals, granules or powder; cool, saline taste. Stable in air; becomes anhydrous at 150 °C. Sol in 1.3 parts water, 0.6 part boiling water. Insol in alcohol. The aqueous soln is slightly alkaline to litmus; pH about 8; /Dihydrate/

Solubility in water, g/100ml at 25 °C: 42.5

This chemical does not meet GHS hazard criteria for 94.3% (1117 of 1184) of all reports.

Not Classified

Aggregated GHS information provided per 1184 reports by companies from 9 notifications to the ECHA C&L Inventory.

This chemical does not meet GHS hazard criteria for 27.7% (41 of 148) of reports.

Warning

H319 (72.3%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

Chemical: 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, trisodium salt

Chemical: 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, sodium salt

1,2,3-Propanetricarboxylic acid, 2-hydroxy-, sodium salt (1:3) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, sodium salt (1:3) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 02-05-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/15303

Trisodium citrate: Does not have an individual approval but may be used under an appropriate group standard

1,2,3-Propanetricarboxylic acid, 2-hydroxy-, sodium salt: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

IMAP assessments - 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, trisodium salt: Environment tier I assessment

IMAP assessments - 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, sodium salt: Human health tier I assessment

B - Blood and blood forming organs

QB - Blood and blood forming organs

Citrate chelates free calcium ions preventing them from forming a complex with tissue factor and coagulation factor VIIa to promote the activation of coagulation factor X. This inhibits the extrinsic initiation of the coagulation cascade. Citrate may also exert an anticoagulant effect via a so far unknown mechanism as restoration of calcium concentration does not fully reverse the effect of citrate. Citrate is a weak base and so reacts with hydrochloric acid in the stomach to raise the pH. It it further metabolized to bicarbonate which then acts as a systemic alkalizing agent, raising the pH of the blood and urine. It also acts as a diuretic and increases the urinary excretion of calcium.

Citrate is metabolized to bicarbonate in the liver and plays a role as an intermediate in the citric acid cycle.

IN THE BODY, SODIUM CITRATE IS OXIDIZED TO BICARBONATE...

SODIUM CITRATE

Anti-coagulant [EPC]; Acidifying Activity [MoA]; Decreased Coagulation Factor Activity [PE]; Calcium Chelating Activity [MoA]; Calculi Dissolution Agent [EPC]

Agents that prevent BLOOD CLOTTING.

A chemical system that functions to control the levels of specific ions in solution. When the level of hydrogen ion in solution is controlled the system is called a pH buffer.

Substances capable of inhibiting, retarding or arresting the process of fermentation, acidification or other deterioration of foods.