Amoxicillin Trihydrate

HCID 62883CAS 61336-70-7
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Grundinformationen

Standard-SMILES
CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](N)c3ccc(O)cc3)C(=O)N2[C@H]1C(=O)O.O.O.O
InChIKey
MQXQVCLAUDMCEF-CWLIKTDRSA-N
Summenformel
C16H25N3O8S
Durchschnittliche Molmasse
419,5 g/mol
Monoisotopische Masse
419,13623576

Überblick

Amoxicillin trihydrate is a hydrate that is the trihydrate form of amoxicillin; a semisynthetic antibiotic, used either alone or in combination with potassium clavulanate (under the trade name Augmentin) for treatment of a variety of bacterial infections. It has a role as an antimicrobial agent and an antibacterial drug. It contains an amoxicillin.

Namen und Bezeichner

Bevorzugter Name
Amoxicillin Trihydrate
IUPAC
(2S,5R,6R)-6-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid;trihydrate
Englischer Name
Amoxicillin trihydrate
Summenformel
C16H21N3O6S
Molmasse
383.42

Namen und Synonyme

Amoxicillin trihydrate61336-70-7AmoxipenMoxalineZimoxAmoxicillin hydrateCHEBI:51254Amoxi-DoserAmoxi-BolAmoxi-SolRobamox-VRobamox-V Tablets
Weitere Namen anzeigen
AMOXYCILLIN TRIHYDRATEAMOXICILIN TRIHYDRATEAmoxiciLAmoxicillineTrihydrateAMOXICILLIN TRIHYDRATE IPAmoxicillin trihydrate for performance verification CRSAm 7A-GramArdine
Biomox, Robamox-VAmoxi-Inject (Cattle)RefChem:54179Amoxi-Drop Oral SuspensionBiomox, Robamox-V TabletsAmoxi-Inject (Dogs and Cats)(2S,5R,6R)-6-((2R)-2-Amino-2-(4-hydroxyphenyl)acetylamino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid trihydrateAmodex

Datenbank-Bezeichner

CAS
61336-70-7
PubChem CID
62883
DTXSID
DTXSID2022599
ChEBI
CHEBI:51254
UNII
804826J2HU
EC Number
612-127-4、688-488-7、933-899-1

Eigenschaften

Berechnete Struktureigenschaften

Polarare Oberfläche (TPSA)
161 Ų
H-Brücken-Donoren
7
H-Brücken-Akzeptoren
10
Frei drehbare Bindungen
4
Schwere Atome
28

Experimentelle und physikochemische Eigenschaften

Animal Drugs · 2 Einträge

Active Ingredients (Amoxicillin Trihydrate) -> FDA Greenbook

Pharmaceuticals -> UK Veterinary Medicines Directorate List

Physikochemische Eigenschaften

Schmelzpunkt
200 °C · >200°C (dec.)
Brechungsindex
302 ° · 302 ° (C=0.1, H2O)
storage temp.
2 · Inert atmosphere,2-8°C
Löslichkeit
Slightly soluble in water, very slightly soluble in ethanol (96 per cent), practically insoluble in fatty oils. It dissolves in dilute acids and dilute solutions of alkali hydroxides.
Aggregatzustand
Solid
Farbe
White to Off-White

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 6 Einträge

Danger

H317 (78%): May cause an allergic skin reaction [Warning Sensitization, Skin]

P233, P260, P261, P271, P272, P273, P280, P284, P302+P352, P304+P340, P321, P333+P317, P342+P316, P362+P364, P391, P403, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 182 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Danger

H317 (50%): May cause an allergic skin reaction [Warning Sensitization, Skin]

Gefahrenhinweise

Regulatory InformationAmoxycillin trihydrate: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationIMAP assessments - 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[amino(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-, trihydrate, [2S-[2.alpha.,5.alpha.,6.beta.(S*)]]-: Environment tier I assessment
Hazard Classes and Categories · 2 Einträge

Skin Sens. 1 (78%)

Skin Sens. 1 (50%)

Sicherheitsdaten

wgk
2
hs_code
29411000
RTECS-Nr.
XH8300000
risk_code
42/43
Toxizität
LD50 ipr-rat: 2870 mg/kg KSRNAM 7,3040,73
hazard_code
Xn,Xi

Chemie und Industrie

Pharmakologische Informationen

MeSH Pharmacological ClassificationSubstances that inhibit the growth or reproduction of BACTERIA.

Verwendung und Herstellung

Use Classification · 2 Einträge

Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients

Veterinary Drug -> -> JECFA Functional Classes

Anwendungen · 2 Einträge

BeschreibungAmoxicillin was synthesized by Beecham Research Laboratories in 1968. A hydroxyl group was introduced on the benzene ring of ampicillin. Amoxicillin shows about a twofold higher serum concentration than ampicillin when administered orally. It was shown by double-blind comparative studies with ampicillin that amoxicillin was as effective as ampicillin when administered at half the dose of ampicillin.

VerwendenAmoxicillin trihydratesemi-synthetic antibiotic related to Penicillin which has antibacterial poperties. It is used for treatment of a variety of bacterial infections. It is used as a pharmaceutical product as a antibiotic agent, anti-infective drug raw materials.

Vor- und nachgelagerte Produkte

Anbieter50 Anbieter

国药集团化学试剂有限公司86-21-63210123 · [email protected]
北京华美互利生物化工010-56205725 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
爱斯特（成都）生物制药股份有限公司+86-28-85122536 85324413 · [email protected]

Ergänzende Hinweise

DefinitionChEBI: A hydrate that is the trihydrate form of amoxicillin; a semisynthetic antibiotic, used either alone or in combination with potassium clavulanate (under the trade name Augmentin) for treatment of a variety of bacterial infections.

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