Amoxicillin Trihydrate
AMOXYCILLIN TRIHYDRATE · AMOXICILIN TRIHYDRATE · AmoxiciL · AmoxicillineTrihydrate · AMOXICILLIN TRIHYDRATE IP · Amoxicillin trihydrate for performance verification CRS · Am 7 · A-Gram
Identifikatoren & physikalische Daten
| CAS No. | 61336-70-7 |
|---|---|
| Summenformel | C16H25N3O8S |
| Durchschnittliche Molmasse | 419,5 g/mol |
| Monoisotopische Masse | 419,13623576 g/mol |
| SMILES | CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](N)c3ccc(O)cc3)C(=O)N2[C@H]1C(=O)O.O.O.O |
| InChIKey | MQXQVCLAUDMCEF-CWLIKTDRSA-N |
| PubChem CID | 62883 |
| ChEBI | CHEBI:51254 |
| EC No. | 612-127-4 |
| DTXSID | DTXSID2022599 |
Chemische & physikalische Eigenschaften
| Polarare Oberfläche (TPSA) | 161 |
|---|---|
| H-Brücken-Donoren | 7 |
| H-Brücken-Akzeptoren | 10 |
| Frei drehbare Bindungen | 4 |
| Schwere Atome | 28 |
| Formalladung | 0 |
| Komplexität | 590 |
| Animal Drugs | Active Ingredients (Amoxicillin Trihydrate) -> FDA GreenbookPharmaceuticals -> UK Veterinary Medicines Directorate List |
| Schmelzpunkt | >200°C (dec.) |
| Brechungsindex | 302 ° (C=0.1, H2O) |
| Lagerbedingungen | Inert atmosphere,2-8°C |
| Löslichkeit | Slightly soluble in water, very slightly soluble in ethanol (96 per cent), practically insoluble in fatty oils. It dissolves in dilute acids and dilute solutions of alkali hydroxides.Soluble in water at 3.4mg/ml. |
| Aggregatzustand | Solid |
| Farbe | White to Off-White |
| Merck | 14,577 |
| JECFA Number | 85 |
| BRN | 7507120 |
| Hauptanwendungen | clinical testing |
| InChIKey | AIPFZZHNBUVELL-KQLYYQCPNA-N |
| SMILES | C([C@H]1C(S[C@]2([H])[C@H](NC(=O)[C@@H](C3C=CC(O)=CC=3)N)C(=O)N12)(C)C)(=O)O.O |&1:1,4,6,10,r| |
| CAS Datenbank | 61336-70-7(CAS DataBase Reference) |
| EPA chemische Informationen | Amoxicillin trihydrate (61336-70-7) |
Sicherheit & Vorschriften
| GHS-Einstufung | DangerH317 (78%): May cause an allergic skin reaction [Warning Sensitization, Skin]P233, P260, P261, P271, P272, P273, P280, P284, P302+P352, P304+P340, P321, P333+P317, P342+P316, P362+P364, P391, P403, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 182 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.H317 (50%): May cause an allergic skin reaction [Warning Sensitization, Skin] |
|---|---|
| Regulatorische Informationen | Amoxycillin trihydrate: Does not have an individual approval but may be used under an appropriate group standard |
| Weitere Sicherheitsinformationen | IMAP assessments - 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[amino(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-, trihydrate, [2S-[2.alpha.,5.alpha.,6.beta.(S*)]]-: Environment tier I assessment |
| Hazard Classes and Categories | Skin Sens. 1 (78%)Skin Sens. 1 (50%) |
| Wassergefährdungsklasse (WGK) | 2 |
| Zollcode | 29411000 |
| RTECS-Nr. | XH8300000 |
| R-Sätze (R) | 42/43 |
| Toxizität | LD50 ipr-rat: 2870 mg/kg KSRNAM 7,3040,73 |
| Gefahrensymbole | Xn,Xi |
| Sicherheitshinweise (S) | 36-36/37-22 |
| Lagerklasse | 11 - Combustible Solids |
| Gefahrenklasse | Resp. Sens. 1Skin Sens. 1 |
Anwendungen & Verwendung
Beschreibung
Amoxicillin was synthesized by Beecham Research Laboratories in 1968. A hydroxyl group was introduced on the benzene ring of ampicillin. Amoxicillin shows about a twofold higher serum concentration than ampicillin when administered orally. It was shown by double-blind comparative studies with ampicillin that amoxicillin was as effective as ampicillin when administered at half the dose of ampicillin.
Verwenden
Amoxicillin trihydratesemi-synthetic antibiotic related to Penicillin which has antibacterial poperties. It is used for treatment of a variety of bacterial infections. It is used as a pharmaceutical product as a antibiotic agent, anti-infective drug raw materials.