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Grundinformationen
- Standard-SMILES
CCC(=O)O[C@]1(C(=O)COC(C)=O)CC[C@H]2[C@@H]3C[C@H](C)C4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C- InChIKey
DALKLAYLIPSCQL-YPYQNWSCSA-N- Summenformel
- C27H36O7
- Durchschnittliche Molmasse
- 472,578 g/mol
- Monoisotopische Masse
- 472,24610349
Namen und Bezeichner
- Bevorzugter Name
- Methylprednisolone aceponate
- IUPAC
- 21-(Acetyloxy)-11-hydroxy-6alpha-methyl-3,20-dioxopregna-1,4-dien-17-yl propanoate
- Englischer Name
- Methylprednisolone aceponate
- Summenformel
- C27H36O7
- Molmasse
- 472.57
Namen und Synonyme
Datenbank-Bezeichner
- CAS
86401-95-8- PubChem CID
- 63019
- DTXSID
DTXSID2023301- ChEMBL
CHEMBL1697782- ChEBI
CHEBI:135762- UNII
- ET54W9J4U2
- EC Number
- 658-084-5、687-724-6
- Nikkaji
- J25.810E
Eigenschaften
Physikochemische Eigenschaften
- Schmelzpunkt
- 105 · 105 - 108°C
- Siedepunkt
- 595.8 · 595.8±50.0 °C(Predicted)
- Dichte
- 1.23 · 1.23±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Löslichkeit
- Chloroform (Slightly), Dioxane (Slightly), DMSO (Slightly), Ethyl Acetate(Slightly)
- pka
- 14.05 · 14.05±0.70(Predicted)
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
- InChIKey
- DALKLAYLIPSCQL-TXWHWSFMNA-N
- SMILES
- O(C(CC)=O)[C@]1(C(COC(C)=O)=O)CC[C@H]2[C@@H]3C[C@H](C)C4=CC(C=C[C@]4(C)[C@H]3[C@H](C[C@]12C)O)=O |&1:5,15,16,18,25,27,28,30,r|
Sicherheit und Regulatorisches
Sicherheitsdaten
- Alarmwort
- Warnung
- Gefahrenhinweise
- Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code H361
Chemie und Industrie
Anwendungen
BeschreibungMethylprednisolone aceponate (MPA) is a new potent topical corticosteroid. Chemically, it is a corticosteroid diester that penetrates the skin rapidly. It is rapidly metabolised and then conjugated, so although potent, it does not appear to cause serious local or systemic side effects. Clinical trials have shown that once daily use is sufficient to control most eczematous conditions and is also appropriate and effective in atopic dermatitis. MPA is effective in the treatment of facial and scalp eczema and sunburn and has shown promising results in the treatment of psoriasis. MPA is also suitable for use in children and infants. MPA is available in a wide range of formulations (0.1%) including creams, ointments, fat ointments, lotions and solutions depending on the patient's individual condition.
VerwendenMethylprednisolone aceponate used in treatment of seborrhoeic dermatitis includes topical treatments such as corticosteroids, antifungals, metronidazole and pimecrolimus.
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