Cyclopropan

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

INHALATION: remove promptly to fresh air; if symptoms of asphyxia- tion persist, administer artificial respiration and oxygen; treat symptomatically thereafter.

General First Aid:

STOP FLOW OF GAS, THEN USE CARBON DIOXIDE, DRY CHEMICAL, OR WATER SPRAY.

Cool exposed containers and protect men effecting shutoff with water.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants.

Excerpt from ERG Guide 115 [Gases - Flammable (Including Refrigerated Liquids)]:

Immediate precautionary measure

150 [mg/m3]

1600 [mg/m3]

9600 [mg/m3]

Self-contained breathing apparatus for high concentrations of vapor; safety goggles or face shield. (USCG, 1999)

Self-contained breathing apparatus for high concn of vapor; safety goggles or face shield.

ONE SERIOUS DRUG INTERACTION INVOLVES SENSITIZATION OF MYOCARDIUM TO CATECHOLAMINES BY CYCLOPROPANE & SOME HALOGENATED HYDROCARBONS... IN PRESENCE OF THESE, ADMIN OF EPINEPHRINE, ISOPROTERENOL, OR LEVARTERENOL MARKEDLY INCREASES INCIDENCE OF CARDIAC ARRHYTHMIAS.

VENTILATION IS PROGRESSIVELY DEPRESSED AS ANESTHESIA IS DEEPENED, PARTICULARLY IF A NARCOTIC ANALGESIC HAS BEEN USED FOR PREMEDICATION...

THE DOSE OF NONDEPOLARIZING NEUROMUSCULAR BLOCKING AGENTS (TUBOCURARINE, METOCURINE, PANCURONIUM, & GALLAMINE) SHOULD BE REDUCED WHEN USED WITH CYCLOPROPANE...BECAUSE THESE ANESTHETICS POTENTIATE MUSCLE RELAXANT EFFECTS OF NEUROMUSCULAR BLOCKING DRUGS.

ANTICHOLINERGIC DRUGS EG ATROPINE, SCOPOLAMINE, & GLYCOPYRROLATE...ARE...USED TO PROTECT AGAINST BRADYCARDIA, HYPOTENSION, & EVEN CARDIAC ARREST INDUCED BY...CYCLOPROPANE...

TERRESTRIAL FATE: Based on a recommended classification scheme(1), an estimated Koc value of 210(SRC), determined from an experimental log Kow of 1.72(2,SRC) and a recommended regression-derived equation(3), indicates that cyclopropane is expected to have moderate mobility in soil(SRC). Volatilization of cyclopropane from moist soil surfaces is expected to occur(SRC) given an estimated Henry's Law constant of 0.79 atm-cu m/mole(SRC), determined from experimental values for vapor pressure, 5.4X10+3 mm Hg(4) and water solubility, 380 mg/l(5). The potential for volatilization of cyclopropane from dry soil surfaces may exist based on a measured vapor pressure of 5.4X10+3 mm Hg(4,SRC).

AQUATIC FATE: Based on a recommended classification scheme(1), an estimated Koc value of 210(SRC), determined from an experimental log Kow of 1.72(2,SRC) and a recommended regression-derived equation(3), indicates that cyclopropane is expected to adsorb to suspended solids and sediment in water(SRC). Cyclopropane is expected to volatilize from water surfaces(3,SRC) based on an estimated Henry's Law constant of 0.79 atm-cu m/mole(4,5,SRC). Estimated half-lives for a model river and model lake are 1.9 hours and 2.6 days, respectively(3,SRC). According to a classification scheme(5), an estimated BCF value of 12(3,SRC), from an experimental log Kow of 1.72(2,SRC), suggests that bioconcentration in aquatic organisms is low(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), cyclopropane, which has an experimental vapor pressure of 5.4X10+3 mm Hg at 25 °C(2,SRC), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase cyclopropane is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the estimated half-life for this reaction in air is about 230 days(3,SRC).

The Koc of cyclopropane is estimated as approximately 210(SRC), using an experimental log Kow of 1.72(1) and a regression-derived equation(2,SRC). According to a recommended classification scheme(3), this estimated Koc value suggests that cyclopropane is expected to have moderate mobility in soil(SRC).

CYCLOPROPANE INCR IRRITABILITY OF PACEMAKER & CONDUCTION TISSUES & VENTRICULAR ARRHYTHMIAS CAN OCCUR, ESPECIALLY IF ANESTHESIA IS DEEP OR VENTILATION IS INADEQUATE & HYPERCAPNIA DEVELOPS.

CYCLOPROPANE IS MINIMALLY IRRITATING TO THE RESPIRATORY TRACT, AND THEREFORE, RESPIRATORY ALTERATIONS SUCH AS BREATH-HOLDING, TACHYPNEA AND COUGHING ARE LESS FREQUENT... LARYNGO-SPASM MAY DEVELOP DURING INDUCTION... DELIRIUM DURING INDUCTION IS NOT UNCOMMON.

A VARIETY OF ARRHYTHMIAS MAY OCCUR DURING THE ADMINISTRATION OF CYCLOPROPANE, INCLUDING SINUS BRADYCARDIA, ATRIAL EXTRASYSTOLES, ATRIAL FIBRILLATION, A-V NODAL RHYTHMS, VENTRICULAR EXTRASYSTOLES, AND BIGEMINAL RHYTHM.

THERE IS NO EVIDENCE THAT CYCLOPROPANE IS HEPATOTOXIC...

For more Human Toxicity Excerpts (Complete) data for CYCLOPROPANE (8 total), please visit the HSDB record page.

An estimated BCF value of 12 was calculated for cyclopropane(SRC), using an experimental log Kow of 1.72(1) and a recommended regression-derived equation(2). According to a classification scheme(3), this BCF value suggests that bioconcentration in aquatic organisms is low(SRC).

The Henry's Law constant for cyclopropane is estimated as 0.79 atm-cu m/mole(SRC) from its experimental values for vapor pressure, 5.4X10+3 mm Hg(1), and water solubility, 380 mg/l(2). This value indicates that cyclopropane will volatilize rapidly from water surfaces(3,SRC). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec) is estimated as approximately 1.9 hours(3,SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec) is estimated as approximately 2.6 days(3,SRC). Cyclopropane is expected to volatilize from moist soil surfaces given an estimated Henry's Law constant of 0.79 atm-cu m/mole(1,2,SRC). The potential for volatilization of cyclopropane from dry soil surfaces may exist(SRC) based on a measured vapor pressure of 5.4X10+3 mm Hg(1).

POST-ANESTHETIC VOMITING OFTEN FOLLOWS THE USE OF CYCLOPROPANE IN SMALL ANIMALS.

CYCLOPROPANE ASSESSED IN VITRO BY MICROBIAL ASSAY EMPLOYING 2 HISTIDINE-DEPENDENT STRAINS OF SALMONELLA TYPHIMURIUM, TA1535 & TA100. CYCLOPROPANE WAS NOT MUTAGENIC.

Cyclopropane acts rapidly in the dog and serves as a model for predicting anesthetic concentrations for human application. In chickens, exposure for 6 hr produced embryonic abnormalities at 10 to 20% and death at 20 to 30% in 12 hr exposures.

CYCLOPROPANE LOWERED THE ARTERIAL PRESSURE OF THE PITHED RAT. HEART RATE WAS UNCHANGED. CYCLOPROPANE DECR THE PRESSOR RESPONSES TO SYMPATHETIC NERVE STIMULATION AND REDUCED MOTOR RESPONSES OF SMOOTH MUSCLE OF THE COLON TO PARASYMPATHETIC STIMULATION.

The experimental rate constant for the vapor-phase reaction of cyclopropane with photochemically-produced hydroxyl radicals is 0.07X10-12 cu cm/molecule-sec at 25 °C(1). This corresponds to an atmospheric half-life of about 230 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1,SRC). Cyclopropane is not expected to undergo hydrolysis or direct photolysis in the environment due to the lack of functional groups to hydrolyze(2,SRC) or its lack of ability to absorb light in the environmental spectrum(SRC).

Cyclopropane

1

10000

Flammable chemical that can be released at a facility.