Isopropylamin

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:

Use water in large amounts, powder, alcohol-resistant foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.

Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.

First rinse with plenty of water for at least 15 minutes, then remove contaminated clothes and rinse again. Refer for medical attention .

Rinse with plenty of water for several minutes (remove contact lenses if easily possible). Refer immediately for medical attention.

Rinse mouth. Give nothing to drink. Do NOT induce vomiting. Refer immediately for medical attention.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

General First Aid:

(General first aid procedures)

Vapors are heavier than air and will collect in low areas. Vapors may travel long distances to ignition sources and flashback. Vapors in confined areas may explode when exposed to fire. Containers may explode in fire. Storage containers and parts of containers may rocket great distances, in many directions.

Vapors are heavier than air and may travel to a source of ignition and flash back.

· Wear positive pressure self-contained breathing apparatus (SCBA).

5.0 [ppm], Ceiling = 10 ppm[German Research Foundation (DFG)]

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary.

Use water spray to cool unopened containers.

... Use dry chemical, carbon dioxide, or foam extinguishers. ... If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Notify local health and fire officials and pollution control agencies. From a secure, explosion-proof location, use water spray to cool exposed containers. If cooling streams are ineffective (venting sound increases in volume and pitch, tank discolors or shows any digns of deforming), withdraw immediately to a secure position.

For more Fire Fighting Procedures (Complete) data for Isopropylamine (6 total), please visit the HSDB record page.

Well closed. Fireproof. Provision to contain effluent from fire extinguishing. Separated from food and feedstuffs. See Chemical Dangers. Store in an area without drain or sewer access.

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Isopropylamine must be stored to avoid contact with oxidizers (such as perchlorates, peroxides, permanganates, chlorates, and nitrates) and strong acids (such as hydrochloric, sulfuric, and nitric) since violent reactions occur. Store in tightly closed containers in a cool, well-ventilated area away from heat. Sources of ignition, such as smoking and open flames, are prohibited where isopropylamine is handled, used, or stored. Metal containers involving the transfer of 5 gallons or more of isopropylamine should be grounded and bonded. Drums must be equipped with self-closing valves, pressure vacuum bungs, and flame arresters. Use only non-sparking tools and eqipment, especially when opening and closing containers of isopropylamine. Wherever isopropylamine is used, handled, manufactured, or stored, use explosion-proof electrical equipment and fittings. Isopropylamine will attack some forms of plastics, rubber, and coatings.

Store in a cool, dry, well-ventilated location. Separate from strong acids, oxidizing materials.

ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Wear respiratory protection. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up: Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations.

SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.

Eliminate all ignition sources. Stop or control the leak, if this can be done without undue risk. Use water spray to cool and disperse vapors, protect personnel, and dilute spills to form nonflammable mixtures. Absorb in noncombustible material for proper disposal.

Evacuate danger area! Remove all ignition sources. Consult an expert! Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Do NOT wash away into sewer. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

For more Cleanup Methods (Complete) data for Isopropylamine (8 total), please visit the HSDB record page.

SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.

SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.

Product: Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material; Contaminated packaging: Dispose of as unused product.

... May be disposed of by atomizing in a suitable combustion chamber equipped with an appropriate effluent gas cleaning device.

Incineration: Incinerate in a suitable combustion chamber with an afterburner and scrubber.

/While/ methyl and ethylamine in combination with nitrite were significantly mutagenic, the Escherichia coli mutagenicity test of carcinogenic isopropylamine in combination with nitrite did not yield a detectable increase in mutation frequency over that due to nitrite alone.

EC50; Species: Chlorella ellipsoidea (Green algae); Conditions: freshwater, static 25 °C, pH 7.2; Concentration: 1X10-9 ug/cell for 90 min; Effect: decreased photosynthesis, oxygen production

EC50; Species: Anabaena catenula (Blue-Green Algae) exponential growth phase; Conditions: freshwater, static, 22 °C; Concentration: 1500 ug/L for 21 days; Effect: decreased population growth rate /98% purity/

EC50; Species: Microcystis aeruginosa (Blue-Green Algae) exponential growth phase; Conditions: freshwater, static, 22 °C; Concentration: 2500 ug/L for 21 days; Effect: decreased population growth rate /98% purity/

EC50; Species: Leptolyngbya boryana (Blue-Green Algae) exponential growth phase; Conditions: freshwater, static, 22 °C; Concentration: 2900 ug/L for 21 days; Effect: decreased population growth rate /98% purity/

For more Ecotoxicity Values (Complete) data for Isopropylamine (11 total), please visit the HSDB record page.

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 11(SRC), determined from a log Kow of 0.26(2) and a regression-derived equation(3), indicates that isopropylamine is expected to have very high mobility in soil(SRC). However, the pKa of isopropylamine is 10.6(4), indicating that this compound will exist almost entirely in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5). Volatilization of isopropylamine from moist soil surfaces is not expected to be an important fate process because this compound exists almost entirely in the cation form at pH values of 5 to 9 and cations do not volatilize. Isopropylamine is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 580 mm Hg at 25 °C(6). A 70-80% of theoretical BOD using activated sludge in the Manometric Respirometry test(7) suggests that biodegradation is an important environmental fate process in soil(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 11(SRC), determined from a log Kow of 0.26(2) and a regression-derived equation(3), indicates that isopropylamine is not expected to adsorb to suspended solids and sediment(SRC). A pKa of 10.6(4) indicates isopropylamine will exist almost entirely in the cation form at pH values of 5 to 9 and, therefore, volatilization from water surfaces is not expected to be an important fate process(SRC). According to a classification scheme(5), an estimated BCF of 3.2(SRC), from its log Kow(2) and a regression-derived equation(3), suggests the potential for bioconcentration in aquatic organisms is low(SRC). A 70-80% of theoretical BOD using activated sludge in the Manometric Respirometry test(6) suggests that biodegradation is an important environmental fate process in water(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), isopropylamine, which has a vapor pressure of 580 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase isopropylamine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 3.3 hours(SRC), calculated from its rate constant of 3.9X10-13 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Isopropylamine does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

Isopropylamine was detected as a volatile component in boiled beef on unknown dates at unknown concentrations(1). Isopropylamine was detected in a sample of maize grain on unknown dates at a concentration of 2.3 mg/kg(2). Isopropylamine is reported as an odor and/or flavor used in cereal, fruit, meat, cheese and diary(3).

Serious local effects by all routes of exposure.

inhalation, skin absorption, ingestion, skin and/or eye contact

IDENTIFICATION AND USE: Isopropylamine is a colorless liquid (a gas above 91 degrees F). It is used as a solvent, intermediate in synthesis of rubber accelerators, pharmaceuticals, dyes, insecticides, bactericides, textile specialties, and surface-active agents, dehairing agent, solubilizer for 2,4-D acid. HUMAN STUDIES: Complaints of nose and throat irritation were reported by volunteer subjects after brief exposures at 10 to 20 ppm. Workers complained of transient visual disturbances (halos around lights) after exposure to the vapor for 8 hours, probably resulting from mild corneal edema, which usually cleared in 3 to 4 hours. ANIMAL STUDIES: A 4-hour exposure of 10,000 mg/cu m (4000 ppm) to 6 rats was not lethal, while all 6 rats died from exposure to 20,000 mg/cu m (8000 ppm). Exposure to a saturated vapor caused the death of all rats within 2 minutes. Isopropylamine produced a severe burn from application of 0.5 mL of a 1% solution. Instillation of 0.005 mL of undiluted compound resulted in severe corneal opacity while 0.5 mL of a 1% solution in water caused severe corneal opacity and iritis. In mice, isopropylamine is essentially an upper respiratory tract-irritating compound. In a one generation reproduction study rats were exposed to isopropylamine at analytical concentrations of 20, 100 or 499 mg/cu m for 6 hr per day (5 days/week) by inhalation (whole body exposure). Clinical signs included incidental fur discoloration and focal hair loss. There were no significant differences in mating and fertility parameters, number of corpora lutea, implantations and resorptions. The was a reduction in mean body weight gain in males in the high dose group. Negative results were reported in bacterial reverse mutation tests for mutagenicity in Salmonella typhimurium (strains included TA1535, TA1537, TA98 and TA100) with and without metabolic activation. The highest non-toxic dose tested was 3333 mg/plate.

Sore throat. Cough. Burning sensation. Shortness of breath. Laboured breathing.

Pain. Redness. Blisters. Skin burns.

Pain. Redness. Severe burns. Loss of vision.

Burning sensation. Burns in mouth and throat. Abdominal cramps. Shock or collapse.

irritation eyes, skin, nose, throat; pulmonary edema; visual disturbance; eye, skin burns; dermatitis

The following link will take the user to the National Toxicology Program (NTP) Test Status of Agents Search page, which tabulates the results and current status of tests such as "Short-Term Toxicity Studies", "Long-term Carcinogenicity Studies", "Developmental Studies", "Genetic Toxicology Studies", etc., performed with this chemical. Testing status for isopropylamine is available.[Available from, as of March 27, 2018: https://ntpsearch.niehs.nih.gov/?e=True&ContentType=Testing+Status]

Before a worker is placed in a job with a potential for exposure to isopropylamine, a licensed health care professional should evaluate and document the worker's baseline health status with thorough medical, environmental, and occupational histories, a physical examination, and physiologic and laboratory tests appropriate for the anticipated occupational risks. These should concentrate on the function and integrity of the eyes, skin, and respiratory system. Medical surveillance for respiratory disease should be conducted using the principles and methods recommended by the American Thoracic Society.

Occupational health interviews and physical examinations should be performed at regular intervals during the employment period, as mandated by any applicable Federal, State, or local standard. Where no standard exists and the hazard is minimal, evaluations should be conducted every 3 to 5 years or as frequently as recommended by an experienced occupational health physician. Additional examinations may be necessary if a worker develops symptoms attributable to isopropylamine exposure. The interviews, examinations, and medical screening tests should focus on identifying the adverse effects of isopropylamine on the eyes, skin, or respiratory system. Current health status should be compared with the baseline health status of the individual worker or with expected values for a suitable reference population.

This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Isopropylamine is produced, as an intermediate or a final product, by process units covered under this subpart.

Isopropylamine

1

10000

Flammable chemical that can be released at a facility.