2,2,2-Trifluorethanol
2,2,2-Trifluoroethanol
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Grundinformationen
- CAS
75-89-8- Standard-SMILES
OCC(F)(F)F- InChIKey
RHQDFWAXVIIEBN-UHFFFAOYSA-N- Summenformel
- C2H3F3O
- Durchschnittliche Molmasse
- 100,04 g/mol
- Monoisotopische Masse
- 100,01359938
Überblick
2,2,2-trifluoroethanol is a fluoroalcohol. It is functionally related to an ethanol.
Namen und Bezeichner
- Bevorzugter Name
- 2,2,2-Trifluoroethanol
- IUPAC
- 2,2,2-trifluoroethanol
- Lokaler Name
- 2,2,2-Trifluorethanol
- Englischer Name
- 2,2,2-Trifluoroethanol
- Summenformel
- C2H3F3O
- Molmasse
- 100.04
Namen und Synonyme
2,2,2-TRIFLUOROETHANOL75-89-8TrifluoroethanolEthanol, 2,2,2-trifluoro-2,2,2-Trifluoroethyl alcoholTrifluoroethyl alcoholFluorinol 85DTXSID0021751beta,beta,beta-Trifluoroethyl alcohol8T8I76KYF1NSC-451DTXCID401751
Weitere Namen anzeigen
TFEA2,2,2-Trifluorethanol2,2,2-TrifluoroethanTrifluoro Ethanol(L)2,2,2-TRIFLUROETHANOLTFETOH
CHEBI:42330Alcohol, TrifluoroethylRefChem:191590200-913-62,2,2-Trifluoroethan-1-OlTFECF3CH2OHNSC 451
Datenbank-Bezeichner
- CAS
75-89-8- PubChem CID
- 6409
- DTXSID
DTXSID0021751- ChEMBL
CHEMBL116675- ChEBI
CHEBI:42330- UNII
- 8T8I76KYF1
- EC Number
- 200-913-6
- Nikkaji
- J2.396E
Eigenschaften
Berechnete StruktureigenschaftenWird ergänzt
- XLogP
- 0,4
- Polarare Oberfläche (TPSA)
- 20,2 Ų
- H-Brücken-Donoren
- 1
- H-Brücken-Akzeptoren
- 4
- Frei drehbare Bindungen
- 0
- Schwere Atome
- 6
- Formalladung
- 0
- Komplexität
- 38,5
Experimentelle und physikochemische Eigenschaften
Chemical ClassesOther Classes -> Halogenated Alcohols
PFAS
PFAS -> PFAS identified in REACH Regulation EC No. 1272/2008
PFAS -> F-telomer alcohols (FTOH)
PFAS -> Suspected persistent, mobile, toxic (PMT) PFAS or PFAS-like compounds
DrugsPharmaceuticals -> Listed in ZINC15
SpringerMaterials PropertiesSchoenflies notation
LogP0.32
Density1.288 @25 °C
Melting Point-44 °C
Vapor Pressure71.3 [mmHg]
Physical Description
Liquid
Colorless liquid with an ethanol-like odor; bp = 74.1 deg C; [Merck Index]
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
This chemical does not meet GHS hazard criteria for 0.6% (1 of 169) of reports.
Danger
H226 (99.4%): Flammable liquid and vapor [Warning Flammable liquids]
P203, P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P318, P319, P321, P330, P332+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 169 reports by companies from 27 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Warning
Gefahrenhinweise
Regulatory Information
Chemical: Ethanol, 2,2,2-trifluoro-
Ethanol, 2,2,2-trifluoro- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Ethanol, 2,2,2-trifluoro- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
Status: Active Update: 10-06-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/13741
2,2,2-Trifluoroethanol: Does not have an individual approval but may be used under an appropriate group standard
Hazards Summary
A skin irritant; Corrosive to eyes; [eChemPortal: ERMA] An irritant; Causes CNS depression in high-dose animal studies; [MSDSonline] In a 4-week inhalation study of rats exposed at 50 ppm, decreased testicular weight and hypospermatogenesis were observed. No adverse effects were observed in rats exposed to 10 ppm. A cluster of 5 exposed workers were reported to have smaller testicles. [AIHA]
Hazard Classes and Categories
Chemie und Industrie
Verwendung und Herstellung
Uses
Used in organic synthesis (anesthetics, pharmaceuticals, and agrochemicals), in polymerizations, as a cleaning solvent, as a working fluid in Rankine-cycle engines, as an eluent in HPLC separations, and as an alternative to CFCs; [Merck Index]
Metal Degreasing [Category: Clean]
U.S. Production2023: 75,000 - <500,000 lb
Industry UsesSolvent
Use ClassificationPFAS -> F-telomer alcohols (FTOH)
General Manufacturing Information
Pharmaceutical and Medicine Manufacturing
Ethanol, 2,2,2-trifluoro-: ACTIVE
Anwendungen
Verwenden2,2,2-Trifluoroethanol (Trifluoroethyl alcohol, TFE) is used to study the conformational states of proteins and the folding refolding processes of proteins.
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Vorgelagerte Rohstoffe
Nachgelagerte Produkte
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