Amlodipine Maleate

HCID 6435922

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Grundinformationen

CAS: 88150-47-4
Standard-SMILES: CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl.O=C(O)/C=C\C(=O)O
InChIKey: TZNOWAJJWCGILX-BTJKTKAUSA-N
Summenformel: C24H29ClN2O9
Durchschnittliche Molmasse: 524,9 g/mol
Monoisotopische Masse: 524,15615819

Überblick

Amlodipine Maleate is the maleate salt of amlodipine, a synthetic phenylpyridine vasodilator with antihypertensive and antianginal effects. Amlodipine inhibits the influx of extracellular calcium ions into myocardial and peripheral vascular smooth muscle cells, thereby preventing vascular and myocardial contraction. Furthermore, decreased myocardial contractility and dilation of the main coronary and systemic arteries lead to increased blood flow and oxygen delivery to the myocardial tissue and decreases total peripheral resistance. This agent may also modulate multi-drug resistance (MDR) activity through inhibition of the p-glycoprotein efflux pump.

Namen und Bezeichner

Bevorzugter Name: Amlodipine Maleate
IUPAC: (Z)-but-2-enedioic acid;3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
Englischer Name: Amlodipine maleate
Summenformel: C30H35ClN2O12S
Molmasse: 524.95

Namen und Synonyme

Amlodipine maleate88150-47-4AmvazCQ27G2BZJMUK-48,340-11UK-48340-11DTXSID601027708RefChem:54171DTXCID901513285Amlodipine (maleate)Amlodipine maleate [USAN]3-ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate maleate

Weitere Namen anzeigen

Amlodipine IH Impurity AAmlodipine maleate USP/EP/BPAmlodipine maleate - Bio-X ?AMLODIPINE MALEATE MM STANDARDAmlodipine maleate (crystalline)Amlodipine maleate, 10 mM in DMSOAmlodipineMaleateC20H25C1N205.C4H4043-Ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5

UNII-CQ27G2BZJMMFCD02259457(Z)-but-2-enedioic acid;3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate1357024-06-6Amlodipine maleate (USAN)C24H29ClN2O9Amlodipine (+-)-form maleateUK 48,340-11

Datenbank-Bezeichner

CAS: 88150-47-4
PubChem CID: 6435922
DTXSID: DTXSID601027708
ChEMBL: CHEMBL1200984
UNII: CQ27G2BZJM
EC Number: 629-849-0

Eigenschaften

Berechnete Struktureigenschaften

Polarare Oberfläche (TPSA): 174 Å²
H-Brücken-Donoren: 4
H-Brücken-Akzeptoren: 11
Frei drehbare Bindungen: 12
Schwere Atome: 36
Formalladung: 0
Komplexität: 765

Experimentelle und physikochemische Eigenschaften

Human Drugs · 2 Einträge

FDA approved drugs -> Active ingredient

Physikochemische Eigenschaften

Schmelzpunkt: 178 · 178-179°
storage temp.: Sealed in dry,Room Temperature
Löslichkeit: DMSO (Slightly), Methanol (Slightly)
Aggregatzustand: Solid
Farbe: Off-White to Pale Yellow
Stabilität: Light Sensitive
InChIKey: TZNOWAJJWCGILX-BTJKTKAUSA-N
SMILES: C1(C2=CC=CC=C2Cl)C(=C(NC(COCCN)=C1C(=O)OCC)C)C(=O)OC.C(/C(=O)O)=C/C(=O)O
CAS Datenbank: 88150 · 88150-47-4(CAS DataBase Reference)

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 4 Einträge

Danger

H301 (40%): Toxic if swallowed [Danger Acute toxicity, oral]

P203, P261, P262, P264, P264+P265, P270, P271, P273, P280, P301+P316, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P318, P319, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 5 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Gefahrenhinweise

Hazard Classes and CategoriesAcute Tox. 3 (40%)

Sicherheitsdaten

Alarmwort: Warnung
Gefahrenhinweise: Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code H302

Chemie und Industrie

Pharmakologische Informationen

MeSH Pharmacological Classification · 3 Einträge

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.

A class of drugs that act by selective inhibition of calcium influx through cellular membranes.

Drugs used to cause dilation of the blood vessels.