Lineomycin Hydrochloride

Lincomycin Hydrochloride Anhydrous

HCID 64710CAS 859-18-7
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Grundinformationen

Standard-SMILES
CCC[C@@H]1C[C@@H](C(=O)N[C@@H]([C@H]2O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O)[C@@H](C)O)N(C)C1.Cl
InChIKey
POUMFISTNHIPTI-BOMBIWCESA-N
Summenformel
C18H35ClN2O6S
Durchschnittliche Molmasse
443 g/mol
Monoisotopische Masse
442,19043552

Überblick

Lincomycin Hydrochloride is the hydrochloride salt form of lincomycin, a lincosamide antibiotic originally identified in actinomycete Streptomyces lincolnensis with activity against gram-positive cocci and anaerobic bacteria.

Namen und Bezeichner

Bevorzugter Name
Lincomycin Hydrochloride Anhydrous
IUPAC
(2S,4R)-N-[(1R,2R)-2-hydroxy-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylsulfanyloxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide;hydrochloride
Lokaler Name
Lineomycin Hydrochloride
Englischer Name
Lincomycin hydrochloride
Summenformel
C18H35ClN2O6S
Molmasse
443

Namen und Synonyme

Lincomycin hydrochloride859-18-7LINCOMYCIN HCLLincomix 20Lincomycin hydrochloride anhydrousLincomixDTXSID7047803GCW8Y9936LLincomycin solubleLincolnensin hydrochlorideDTXCID9027780Lincomycin hydrochloride anhdrous
Weitere Namen anzeigen
Lincomycin hydrochloride monohydrateLincomycin HCILincorexLintamycinMETHYL 6,8-DIDEOXY-6-(1-METHYL-4-PROPYL-2-PYRROLIDINECARBOXAMIDO)-1-THIO-D-ERYTHRO-ALPHA-D-GALACTOOCTOPYRANOSIDE HYDROCHLORIDE(2S,4R)-N-((1R,2R)-2-Hydroxy-1-((2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)propyl)-1-methyl-4-propylpyrrolidine-2-carboxamide hydrochlorideLizpionU-10149ALincogap
D-erythro-alpha-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-(((1-methyl-4-propyl-2-pyrrolidinyl)carbonyl)amino)-1-thio-, monohydrochloride, (2S-trans)-NSC70731NSC-70731NSC-757092Linco SolubleLinxMed-SPLincomix 50LincoBac 300

Datenbank-Bezeichner

CAS
859-18-7
PubChem CID
64710
DTXSID
DTXSID7047803
ChEMBL
CHEMBL3989551
UNII
GCW8Y9936L
EC Number
212-726-7

Eigenschaften

Berechnete Struktureigenschaften

Polarare Oberfläche (TPSA)
148 Ų
H-Brücken-Donoren
6
H-Brücken-Akzeptoren
8
Frei drehbare Bindungen
7
Schwere Atome
28

Experimentelle und physikochemische Eigenschaften

Human Drugs · 2 Einträge

FDA approved drugs -> Active ingredient

FDA approved drugs -> Active ingredient

Animal DrugsActive Ingredients (Lincomycin Hydrochloride) -> FDA Greenbook
Collision Cross Section199.1 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

Physikochemische Eigenschaften

Schmelzpunkt
156 · 156-158C
storage temp.
2 · 2-8°C
Löslichkeit
2 O: · H2O: 50 mg/mL, clear, colorless
Aggregatzustand
solid
Farbe
white to white with yellow cast
Wasserlöslichkeit
Soluble in water.

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 4 Einträge

Warning

H315 (62.2%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P272, P273, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P333+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 82 reports by companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Gefahrenhinweise

Regulatory Information · 2 Einträge

Status: Active Update: 17-03-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/33514

lincomycin hydrochloride: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

Other Safety InformationIMAP assessments - D-erythro-.alpha.-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-, monohydrochloride, (2S-trans)-: Environment tier I assessment
Hazard Classes and CategoriesSkin Irrit. 2 (62.2%)

Toxikologische Informationen

Drug Induced Liver Injury · 6 Einträge

Drug Induced Liver Injury Rank (DILIrank 2.0)

Lincomycin hydrochloride

Ambiguous-DILI-concern

3

Warnings & precautions

DOI:10.1016/j.drudis.2016.02.015

Sicherheitsdaten

F
10
wgk
2
hs_code
29419000
RTECS-Nr.
RH6315000
risk_code
36/37/38-20/21/22
hazard_code
Xi,Xn

Chemie und Industrie

Pharmakologische Informationen

MeSH Pharmacological Classification · 2 Einträge

Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins.

Substances that inhibit the growth or reproduction of BACTERIA.

Verwendung und Herstellung

Use ClassificationAnimal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
Anwendungen · 1 Eintrag

VerwendenLincomycin hydrochloride is a salt of lincomycin formed at the basic N-methylproline. The hydrochloride salt is the preferred formulation for pharmaceutical use. Lincomycin hydrochloride is a broad spectrum antibiotic with activity against anaerobic bacteria and protozoans. Lincomycin acts by binding to the 23S ribosomal subunit, blocking protein synthesis. Lincomycin has been extensively studied with over 7,000 literature citations.

Vor- und nachgelagerte Produkte

Vorgelagerte Rohstoffe

Anbieter50 Anbieter

北京华美互利生物化工010-56205725 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
上海如吉生物科技发展有限公司+86-21-65211385-8001 36031160 · [email protected]
广州隽唐科技有限公司020-36607679 13502246435 · [email protected]
LGM Pharma1-(800)-881-8210 · [email protected]

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