Lineomycin Hydrochloride

LINCOMYCIN HCL · Lincomycin hydrochloride monohydrate · Lincomycin HCI · Lincorex · Lintamycin · METHYL 6,8-DIDEOXY-6-(1-METHYL-4-PROPYL-2-PYRROLIDINECARBOXAMIDO)-1-THIO-D-ERYTHRO-ALPHA-D-GALACTOOCTOPYRANOSIDE HYDROCHLORIDE · (2S,4R)-N-((1R,2R)-2-Hydroxy-1-((2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)propyl)-1-methyl-4-propylpyrrolidine-2-carboxamide hydrochloride · Lizpion

https://huagongshe.com/de/chemical/64710

Molekülstruktur von Lineomycin Hydrochloride

Identifikatoren & physikalische Daten

CAS No.	859-18-7
Summenformel	C18H35ClN2O6S
Durchschnittliche Molmasse	443 g/mol
Monoisotopische Masse	442,19043552 g/mol
SMILES	CCC[C@@H]1C[C@@H](C(=O)N[C@@H]([C@H]2O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O)[C@@H](C)O)N(C)C1.Cl
InChIKey	POUMFISTNHIPTI-BOMBIWCESA-N
PubChem CID	64710
ChEMBL	CHEMBL3989551
EC No.	212-726-7
DTXSID	DTXSID7047803
Lokaler Name	Lineomycin Hydrochloride

Chemische & physikalische Eigenschaften

Polarare Oberfläche (TPSA)	148
H-Brücken-Donoren	6
H-Brücken-Akzeptoren	8
Frei drehbare Bindungen	7
Schwere Atome	28
Formalladung	0
Komplexität	498
Human Drugs	FDA approved drugs -> Active ingredient
Animal Drugs	Active Ingredients (Lincomycin Hydrochloride) -> FDA Greenbook
Collision Cross Section	199.1 Å² [M+H]+ [CCS Type: TWMethod: calibrated with polyalanine and drug standards]
Schmelzpunkt	156-158C
Lagerbedingungen	2-8°C
Löslichkeit	H2O: 50 mg/mL, clear, colorlessSoluble in water.
Aggregatzustand	solid
Farbe	white to white with yellow cast
BRN	4171650
Stabilität	Hygroscopic
InChIKey	POUMFISTNHIPTI-BOMBIWCESA-N
SMILES	[C@]([H])([C@]1([H])[C@@H]([C@H](O)[C@@H](O)[C@@H](SC)O1)O)([C@H](O)C)NC([C@H]1N(C[C@H](CCC)C1)C)=O.Cl \|&1:0,2,4,5,7,9,14,19,22,r\|
EPA chemische Informationen	D-erythro-.alpha.-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-, hydrochloride (1:1) (859-18-7)

Sicherheit & Vorschriften

GHS-Einstufung	WarningH315 (62.2%): Causes skin irritation [Warning Skin corrosion/irritation]P261, P264, P264+P265, P271, P272, P273, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P333+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 82 reports by companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Regulatorische Informationen	Status: Active Update: 17-03-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/33514lincomycin hydrochloride: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Weitere Sicherheitsinformationen	IMAP assessments - D-erythro-.alpha.-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-, monohydrochloride, (2S-trans)-: Environment tier I assessment
Hazard Classes and Categories	Skin Irrit. 2 (62.2%)
Drug Induced Liver Injury	Drug Induced Liver Injury Rank (DILIrank 2.0)Lincomycin hydrochlorideAmbiguous-DILI-concern3Warnings & precautionsDOI:10.1016/j.drudis.2016.02.015
F	10
Wassergefährdungsklasse (WGK)	2
Zollcode	29419000
RTECS-Nr.	RH6315000
R-Sätze (R)	36/37/38-20/21/22
Gefahrensymbole	Xi,Xn
Sicherheitshinweise (S)	26-36
Lagerklasse	11 - Combustible Solids

Anwendungen & Verwendung

Verwenden

Lincomycin hydrochloride is a salt of lincomycin formed at the basic N-methylproline. The hydrochloride salt is the preferred formulation for pharmaceutical use. Lincomycin hydrochloride is a broad spectrum antibiotic with activity against anaerobic bacteria and protozoans. Lincomycin acts by binding to the 23S ribosomal subunit, blocking protein synthesis. Lincomycin has been extensively studied with over 7,000 literature citations.