Grundinformationen
- CAS
32909-92-5- Standard-SMILES
COc1nsnc1NS(=O)(=O)c1ccc(N)cc1- InChIKey
IZOYMGQQVNAMHS-UHFFFAOYSA-N- Summenformel
- C9H10N4O3S2
- Durchschnittliche Molmasse
- 286,3 g/mol
- Monoisotopische Masse
- 286,01943218
Überblick
Sulfametrole is a sulfonamide obtained by formal condensation of the sulfo group of 4-aminobenzenesulfonic acid with the amino group of 4-methoxy-1,2,5-thiadiazol-3-amine. It is an aromatic ether, a member of thiadiazoles, a substituted aniline and a sulfonamide antibiotic. It derives from a hydride of a 1,2,5-thiadiazole.
Namen und Bezeichner
- Bevorzugter Name
- Sulfametrole
- IUPAC
- 4-amino-N-(4-methoxy-1,2,5-thiadiazol-3-yl)benzenesulfonamide
- Lokaler Name
- Sulfametrol
- Englischer Name
- sulfametrole
- Summenformel
- C9H10N4O3S2
- Molmasse
- 286.33
Namen und Synonyme
Sulfametrole32909-92-5SulfametrolSulfametrolum4-amino-N-(4-methoxy-1,2,5-thiadiazol-3-yl)benzenesulfonamideF5AK41IPQGCHEBI:88258DTXSID40865655sulfametroloRefChem:186501DTXCID00206121N-(4-methoxy-1,2,5-thiadiazol-3-yl)sulfanilamide
Weitere Namen anzeigen
Benzenesulfonamide, 4-amino-N-(4-methoxy-1,2,5-thiadiazol-3-yl)-
251-288-1N1-(4-Methoxy-1,2,5-thiadiazol-3-yl)sulfanilamideSulfametrole (INN)4-amino-N-(4-methoxy-1,2,5-thiadiazol-3-yl)benzene-1-sulfonamideSULFAMETROLE [INN]UNII-F5AK41IPQGSulfametrole [INN:BAN]Sulfametrol [INN-Spanish]
Datenbank-Bezeichner
- CAS
32909-92-5- PubChem CID
- 64939
- DTXSID
DTXSID40865655- ChEMBL
CHEMBL2105398- ChEBI
CHEBI:88258- UNII
- F5AK41IPQG
- EC Number
- 251-288-1
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 0,8
- Polarare Oberfläche (TPSA)
- 144 Ų
- H-Brücken-Donoren
- 2
- H-Brücken-Akzeptoren
- 8
- Frei drehbare Bindungen
- 4
- Schwere Atome
- 18
- Formalladung
- 0
- Komplexität
- 364
Experimentelle und physikochemische Eigenschaften
Drugs
Pharmaceuticals -> Antibiotics
Pharmaceuticals -> Antibiotics
Physikochemische Eigenschaften
- Schmelzpunkt
- 149 · 149-150°
- Siedepunkt
- 496 · 496.0±55.0 °C(Predicted)
- Dichte
- 1.584 · 1.584±0.06 g/cm3(Predicted)
- storage temp.
- Refrigerator
- Löslichkeit
- DMSO (Slightly), Methanol (Slightly)
- Aggregatzustand
- Solid
- pka
- 4.89 · 4.89±0.10(Predicted)
- Farbe
- White to Pale Beige
Chemie und Industrie
Pharmakologische Informationen
Mechanism of ActionSulfametrole is a sulfonamide antibiotic. While the exact mechanism of action of this drug has not been fully elucidated, it is likely to share the actions of other sulfonamides, such as the inhibition of carbonic anhydrase.
Anwendungen
VerwendenSulfametrole combined with Trimethoprim (T795615) has shown to be effective against Pneumocystis jiroveci infection in HIV-infected patients, severe pneumonia and urinary tract infections.
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