Hydrochloric Acid → Sulfametrole

HRID 26634Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 26634
[CH3:1][O:2][C:3]1[C:7](Cl)=[N:6][S:5][N:4]=1.CS(C)=O.[S:13]([NH2:23])(=[O:22])([C:15]1[CH:20]=[CH:19][C:18]([NH2:21])=[CH:17][CH:16]=1)=[O:14].C(=O)([O-])[O-].[K+].[K+].Cl>O>[CH3:1][O:2][C:3]1[C:7]([NH:23][S:13]([C:15]2[CH:16]=[CH:17][C:18]([NH2:21])=[CH:19][CH:20]=2)(=[O:14])=[O:22])=[N:6][S:5][N:4]=1

Komponenten

7

Edukt 5

HCID 313Hydrochloric AcidHCID 679Dimethyl SulfoxideHCID 5333SulfanilamideHCID 11430Potassium CarbonateHCID 181772483-Chloro-4-methoxy-1,2,5-thiadiazole

Produkt 1

HCID 64939SulfametroleAusbeute 94,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

150.6 g of 3-methoxy-4-chloro-1,2,5-thiadiazole (1 mole) were suspended in 156.26 g of dimethyl sulfoxide (2 mole) and 258.31 g of sulfanilamide (1.5 mole) and 414.63 g of potassium carbonate (3 mole) were then added. The mixture was kept at 70° C. for 48 hours while stirring. 600 ml of water were then added, the mixture was cooled to ambient temperature and adjusted to pH 1.5 with concentrated hydrochloric acid. The precipitated crystallized material was filtered off, washed with water and dried. A yield of 271.1 g of crude 3-methoxy-4-(4'-aminobenzenesulfonamido)-1,2,5-thiadiazole (94.67% of theory), melting point 138°-146° C., was obtained.

Aufarbeitung

  1. customThe precipitated crystallized material
  2. filtrationwas filtered off
  3. washwashed with water
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-465fd41c1f3c446db97935adfb6ccdaa
Quelldatensatz
uspto-grants-1979_04
Patentnummer
US04151164

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