Grundinformationen
- Standard-SMILES
CCC(=O)N(c1ccccc1)C1(COC)CCN(CCc2cccs2)CC1.O=C(O)CC(O)(CC(=O)O)C(=O)O- InChIKey
OJCZPLDERGDQRJ-UHFFFAOYSA-N- Summenformel
- C28H38N2O9S
- Durchschnittliche Molmasse
- 578,7 g/mol
- Monoisotopische Masse
- 578,2298018
Überblick
Sufentanil citrate is an anilide.
Namen und Bezeichner
- Bevorzugter Name
- Sufentanil Citrate
- IUPAC
- 2-hydroxypropane-1,2,3-tricarboxylic acid;N-[4-(methoxymethyl)-1-(2-thiophen-2-ylethyl)piperidin-4-yl]-N-phenylpropanamide
- Lokaler Name
- N-[4-(Methoxymethyl)-1-[2-(2-thienyl)ethyl]-4-piperidyl]-N-phenylpropionamidcitrat
- Englischer Name
- SUFENTANIL CITRATE
- Summenformel
- C28H38N2O9S
- Molmasse
- 578.68
Namen und Synonyme
Sufentanil citrate60561-17-3FentatienilSufentanil citrate ciiDTXSID5048928Sufenta Preservative FreeDSUVIAS9ZFX8403RR-33800DTXCID2028854N-(4-(Methoxymethyl)-1-(2-(2-thienyl)ethyl)-4-piperidyl)propionanilide citrateN-(4-(Methoxymethyl)-1-(2-(2-thienyl)ethyl)-4-piperidyl)-N-phenylpropionamide citrate
Weitere Namen anzeigen
r33800Sufentanil Forter30730citratesaltsufentanylcitrateSufentanyl CitratSUFENTANILCITRATE,USPSufentanil citrate saltRezvilutamide Impurity 38
SufentalRefChem:58797262-295-4Propanamide, N-(4-(methoxymethyl)-1-(2-(thienyl)ethyl)-4-piperidinyl)-N-phenyl-, 2-hydroxy-1,2,3-propanetricarboxylate(1:1)SufentaSufentanil (citrate)R 338002-hydroxypropane-1,2,3-tricarboxylic acid;N-[4-(methoxymethyl)-1-(2-thiophen-2-ylethyl)piperidin-4-yl]-N-phenylpropanamide
Datenbank-Bezeichner
- CAS
60561-17-3- PubChem CID
- 65494
- DTXSID
DTXSID5048928- ChEMBL
CHEMBL1201163- ChEBI
CHEBI:9317- UNII
- S9ZFX8403R
- EC Number
- 262-295-4
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 193 Ų
- H-Brücken-Donoren
- 4
- H-Brücken-Akzeptoren
- 11
- Frei drehbare Bindungen
- 13
- Schwere Atome
- 40
- Formalladung
- 0
- Komplexität
- 687
Experimentelle und physikochemische Eigenschaften
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Physikochemische Eigenschaften
- Schmelzpunkt
- 96.6 C · 96.60C
- Flammpunkt
- 9 ℃ · 9℃
- storage temp.
- -20 °C · -20°C Freezer
- Löslichkeit
- 2 O: · H2O: soluble1mg/mL, clear
- Aggregatzustand
- powder
- Farbe
- white to beige
- Stabilität
- Hygroscopic
Sicherheit und Regulatorisches
GHS-Klassifizierung
GHS Classification
Danger
H300+H310+H330 (90.7%): Fatal if swallowed, in contact with skin or if inhaled [Danger Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]
P260, P262, P264, P270, P271, P280, P284, P301+P316, P302+P352, P304+P340, P316, P320, P321, P330, P361+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 43 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Other Safety InformationIMAP assessments - Propanamide, N-[4-(methoxymethyl)-1-[2-(2-thienyl)ethyl]-4-piperidinyl]-N-phenyl-, 2-hydroxy-1,2,3-propane tricarboxylate (1:1): Environment tier I assessment
Hazard Classes and CategoriesAcute Tox. 2 (100%)
Toxikologische Informationen
Drug Induced Liver Injury
Drug Induced Liver Injury Rank (DILIrank 2.0)
Sufentanil citrate
vNo-DILI-concern
0
No match
DOI:10.1016/j.drudis.2016.02.015
Sicherheitsdaten
- wgk
- 3
- ridadr
- 3249
- hs_code
- 2934910000
- risk_code
- 26/27/28-39/23/24/25-23/24/25-11
- Toxizität
- LD50 intravenous in dog: 14100ug/kg
- hazard_code
- T+,T,F
- safety_code
- 26-27-28-36/37/39-45-36/37-16-7
- hazard_class
- 6.1(b)
- packing_group
- III
Chemie und Industrie
Pharmakologische Informationen
FDA Pharmacological Classification
SUFENTANIL CITRATE
Opioid Agonist [EPC]; Full Opioid Agonists [MoA]
MeSH Pharmacological Classification
Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS.
Agents that are administered in association with anesthetics to increase effectiveness, improve delivery, or decrease required dosage.
Agents that induce NARCOSIS. Narcotics include agents that cause somnolence or induced sleep (STUPOR); natural or synthetic derivatives of OPIUM or MORPHINE or any substance that has such effects. They are potent inducers of ANALGESIA and OPIOID-RELATED DISORDERS.
Ultrashort-acting anesthetics that are used for induction. Loss of consciousness is rapid and induction is pleasant, but there is no muscle relaxation and reflexes frequently are not reduced adequately. Repeated administration results in accumulation and prolongs the recovery time. Since these agents have little if any analgesic activity, they are seldom used alone except in brief minor procedures. (From AMA Drug Evaluations Annual, 1994, p174)
Anwendungen
VerwendenPotent derivative of Fentanyl. Analgesic (narcotic). Controlled substance (opiate)
Zugehörige Reaktionen
1
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