Ropinirole Hydrochloride

HCID 68727

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Grundinformationen

CAS: 91374-20-8
Standard-SMILES: CCCN(CCC)CCc1cccc2c1CC(=O)N2.Cl
InChIKey: XDXHAEQXIBQUEZ-UHFFFAOYSA-N
Summenformel: C16H25ClN2O
Durchschnittliche Molmasse: 296,83 g/mol
Monoisotopische Masse: 296,1655411

Überblick

Ropinirole hydrochloride is a member of indoles.

Namen und Bezeichner

Bevorzugter Name: Ropinirole Hydrochloride
IUPAC: 4-[2-(dipropylamino)ethyl]-1,3-dihydroindol-2-one;hydrochloride

Namen und Synonyme

Ropinirole hydrochloride91374-20-8Ropinirole HClReQuip XLSK&F 101468-ARopinirole (as hydrochloride)D7ZD41RZI9SK&F-101468-A4-(2-(Dipropylamino)ethyl)-2-indolinone monohydrochlorideDTXCID00161024DTXSID502385332(H)-Indol-2-one, 4-(2-(dipropylamino)ethyl)-1,3-dihydro-, monohydrochloride

Weitere Namen anzeigen

4-[2-(Dipropylamino)ethyl]-2-indolinone monohydrochlorideRopilynz xlAimpart xlIpinnia xlRaponer xlRepinex xlSpiroco xlRalnea xl

Datenbank-Bezeichner

CAS: 91374-20-8
PubChem CID: 68727
DTXSID: DTXSID50238533
ChEMBL: CHEMBL1200411
ChEBI: CHEBI:8889
UNII: D7ZD41RZI9
EC Number: 635-615-9

Eigenschaften

Berechnete StruktureigenschaftenWird ergänzt

Polarare Oberfläche (TPSA): 32,3 Å²
H-Brücken-Donoren: 2
H-Brücken-Akzeptoren: 2
Frei drehbare Bindungen: 7
Schwere Atome: 20
Formalladung: 0
Komplexität: 286

Experimentelle und physikochemische Eigenschaften

Human Drugs · 2 Einträge

FDA approved drugs -> Active ingredient

Animal DrugsEMA approved medicines: Veterinary medicine

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 4 Einträge

Warning

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

P264, P270, P273, P301+P317, P330, P391, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 49 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Gefahrenhinweise

Regulatory InformationRopinirole hydrochloride: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

Hazard Classes and CategoriesAcute Tox. 4 (100%)

Toxikologische Informationen

TreatmentGeneral supportive measures are recommended. Vital signs should be maintained, if necessary. Removal of any unabsorbed material (e.g., by gastric lavage) should be considered. (L1712)

Exposure RoutesOral. Absolute bioavailability is 55%, indicating a first pass effect. Food does not affect the extent of absorption.

Toxicity Summary · 1 Eintrag

Ropinirole binds the dopamine receptors D<sub>3</sub> and D<sub>2</sub>. Although the precise mechanism of action of ropinirole as a treatment for Parkinson's disease is unknown, it is believed to be related to its ability to stimulate these receptors in the striatum. This conclusion is supported by electrophysiologic studies in animals that have demonstrated that ropinirole influences striatal neuronal firing rates via activation of dopamine receptors in the striatum and the substantia nigra, the site of neurons that send projections to the striatum.

Signs and Symptoms · 1 Eintrag

Symptoms of overdose include agitation, chest pain, confusion, drowsiness, facial muscle movements, grogginess, increased jerkiness of movement, symptoms of low blood pressure (dizziness, light-headedness)upon standing, nausea, and vomiting.

Carcinogen ClassificationNo indication of carcinogenicity to humans (not listed by IARC).

Drug Induced Liver Injury · 6 Einträge

Drug Induced Liver Injury Rank (DILIrank 2.0)

Ropinirole hydrochloride

vLess-DILI-concern

Adverse reactions

DOI:10.1016/j.drudis.2016.02.015

Chemie und Industrie

Pharmakologische Informationen

Metabolism/Metabolites · 1 Eintrag

Hepatic. Ropinirole is extensively metabolized to inactive metabolites via N -despropylation and hydroxylation pathways, largely by the P450 isoenzyme CYP1A2. N-despropyl ropinirole is the predominant metabolite found in urine (40%), followed by the carboxylic acid metabolite (10%), and the glucuronide of the hydroxy metabolite (10%). Route of Elimination: Ropinirole is extensively metabolized by the liver to inactive metabolites, and less than 10% of the administered dose is excreted as unchanged drug in urine. Half Life: 6 hours

FDA Pharmacological Classification · 2 Einträge

ROPINIROLE HYDROCHLORIDE

Dopamine Agonists [MoA]; Nonergot Dopamine Agonist [EPC]

MeSH Pharmacological Classification · 2 Einträge

Agents used in the treatment of Parkinson's disease. The most commonly used drugs act on the dopaminergic system in the striatum and basal ganglia or are centrally acting muscarinic antagonists.

Drugs that bind to and activate dopamine receptors.