Ropinirole Hydrochloride → Ropinirole
Reaktionsgleichung
[CH3:1][CH2:2][CH2:3][N:4]([CH2:8][CH2:9][C:10]1[CH:11]=[CH:12][CH:13]=[C:14]2[NH:19][C:17](=[O:18])[CH2:16][C:15]=12)[CH2:5][CH2:6][CH3:7].Cl.CC1C([N+]([O-])=O)=CC=CC=1CC(O)=O>>[CH3:7][CH2:6][CH2:5][N:4]([CH2:8][CH2:9][C:10]1[CH:11]=[CH:12][CH:13]=[C:14]2[NH:19][C:17](=[O:18])[CH2:16][C:15]=12)[CH2:3][CH2:2][CH3:1]Komponenten
Versuchsvorschrift
The processes for the preparation of Ropinirole HCl and its derivatives have previously been described. U.S. Pat. No. 4,452,808 describes the preparation of 4-aminoalkyl-2(3H)-indolones starting from either 4-aminoalkyl-7-hydroxy-2(3H)-indolones or 2-methyl-3-nitro-benzene acetic acid by two different processes. The 7-hydroxy intermediate (i) is first converted to its tetrazolo derivative (ii) which is then hydrogenated to get Ropinirole as shown in Scheme 1. Preparation of 7-hydroxy intermediate (i) is described in U.S. Pat. No. 4,314,944 by following a series of steps starting from p-methoxy phenethylamine. Second process described in U.S. Pat. No. 4,452,808 allows preparation of Ropinirole by following a series of steps starting from 2-methyl-3-nitro benzeneacetic acid.
Quellen und Nachweise
- ORD-Eintrag
- ord-bc697f6b2e734f049e3c4f225f30f939
- Quelldatensatz
- uspto-grants-2008_05
- Patentnummer
- US07378439B2
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