Cyclopropylamin
Cyclopropylamine
Grundinformationen
- CAS
765-30-0- Standard-SMILES
NC1CC1- InChIKey
HTJDQJBWANPRPF-UHFFFAOYSA-N- Summenformel
- C3H7N
- Durchschnittliche Molmasse
- 57,09 g/mol
- Monoisotopische Masse
- 57,05784923
Überblick
Cyclopropylamine is a primary aliphatic amine that consists of cyclopropane bearing a single amino substituent. It has a role as a mouse metabolite.
Namen und Bezeichner
- Bevorzugter Name
- Cyclopropylamine
- IUPAC
- cyclopropanamine
- Lokaler Name
- Cyclopropylamin
- Englischer Name
- Cyclopropylamine
- Summenformel
- C3H7N
- Molmasse
- 57.09
Namen und Synonyme
CyclopropylamineCyclopropanamine765-30-0Aminocyclopropane8PR8XTH1X1NSC-56127DTXSID9061099CHEBI:34660RefChem:581232DTXCID8047890212-142-2cyclopropyamine
Weitere Namen anzeigen
AURORA KA-2551CydopropylamineCyloprolylamineRing propylaMineAMINOTRIMETHYLENEAKOS BBS-00003593
cyclopropylamincylopropylamineCycloproplyamineCyclopropaneamineCyclopropylarnineMoxifloxacin Impurity 90N-cyclopropylamineMFCD00001301
Datenbank-Bezeichner
- CAS
765-30-0- PubChem CID
- 69828
- DTXSID
DTXSID9061099- ChEBI
CHEBI:34660- UNII
- 8PR8XTH1X1
- EC Number
- 212-142-2
- Nikkaji
- J79.937H
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 0,1
- Polarare Oberfläche (TPSA)
- 26 Ų
- H-Brücken-Donoren
- 1
- H-Brücken-Akzeptoren
- 1
- Frei drehbare Bindungen
- 0
- Schwere Atome
- 4
- Formalladung
- 0
- Komplexität
- 22,5
Experimentelle und physikochemische Eigenschaften
SpringerMaterials PropertiesCoriolis coupling
LogP0.07
Physical DescriptionLiquid
Physikochemische Eigenschaften
- Schmelzpunkt
- 35.4 °C · −35.4 °C (−31.7 °F; 237.8 K)
- Siedepunkt
- 49 · 49–50 °C (120–122 °F; 322–323 K)
- Dichte
- 0.82 · 0.82
- Dampfdruck
- 4.67 psi · 4.67 psi ( 20 °C)
- Brechungsindex
- 1.42 · 1.42
- Flammpunkt
- 1 °C · 1 °C
- storage temp.
- 30 °C · Store below +30°C.
- Löslichkeit
- Chloroform, Ethyl Acetate (Sparingly), Methanol (Slightly)
- pka
- 1 · pK1:9.10(+1) (25°C)
- Aggregatzustand
- liquid
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Danger
H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]
P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P272, P273, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P321, P330, P333+P317, P362+P364, P363, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 203 reports by companies from 12 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Regulatory Information
Chemical: Cyclopropanamine
Cyclopropanamine is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Cyclopropanamine are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
REACH registered substance: Cyclopropylamine (EC: 212-142-2)
Cyclopropylamine: HSNO Approval: HSR004423 Approved with controls
Hazard Classes and CategoriesFlam. Liq. 2 (100%)
Sicherheitsdaten
- wgk
- 2
- tsca
- TSCA listed
- ridadr
- UN 2733 3/PG 2
- hs_code
- 2921300090
- RTECS-Nr.
- GZ0685500
- risk_code
- 11-22-34-36/37
- Toxizität
- LD50 orally in Rabbit: 445 mg/kg
Chemie und Industrie
Verwendung und Herstellung
U.S. Production2023: <50,000 lb
Industry UsesIntermediate
General Manufacturing Information
Pesticide, Fertilizer, and Other Agricultural Chemical Manufacturing
Cyclopropanamine: ACTIVE
Anwendungen
VerwendenCyclopropylamine is used in the preparation of N-[4-(4-fluoro)phenyl-2-aminothiazol-5-yl]pyrimidin-2-yl-alkylamine derivatives. It is also used to prepare Pt(CPA)2(bismethylthiomethylenepropanedioate) and Pt(CPA)2(bisethylthiomethylenepropanedioate) complexes.
Darstellung
synthetischeCyclopropylamine is synthesized from 1,3-propanediol by bromination, cyanation, cyclization, amidation, and Hoffmann rearrangement. It is also synthesized with γ-butyrolactone and isopropanol by five steps of ring-opening esterification, cyclization, hydrolysis, acylation and Hofmann degradation.
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