Dichloromethane → N-cyclopropyl-2-[[2-(cyclopropylcarbamoyl)phenyl]disulfanyl]benzamide
Reaktionsgleichung
[C:1](Cl)(=[O:19])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8][S:9][C:10]1[CH:18]=[CH:17][CH:16]=[CH:15][C:11]=1[C:12](Cl)=[O:13].[CH:21]1([NH2:24])[CH2:23][CH2:22]1.C([N:27]([CH2:30][CH3:31])CC)C.Cl[CH2:33]Cl>>[CH:21]1([NH:24][C:1](=[O:19])[C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=2[S:8][S:9][C:10]2[CH:18]=[CH:17][CH:16]=[CH:15][C:11]=2[C:12]([NH:27][CH:30]2[CH2:31][CH2:33]2)=[O:13])[CH2:23][CH2:22]1Komponenten
5
Versuchsvorschrift
A solution of 2,2'-dithiobisbenzoyl chloride (1.0 g, 3.0 mmol) in 20 mL of dichloromethane was added dropwise to a solution of cyclopropylamine (0.52 mL, 7.5 mmol) and triethylamine (1.2 mL, 9.0 mmol) in 20 mL of dichloromethane. A solid formed immediately, the mixture was stirred for 3 hours and then filtered. The solid was dried to yield 0.65 g of the title compound, mp 257°-259° C.;