Phenylacetylchlorid

Phenylacetyl chloride

HCID 7679CAS 103-80-0

Grundinformationen

Standard-SMILES
O=C(Cl)Cc1ccccc1
InChIKey
VMZCDNSFRSVYKQ-UHFFFAOYSA-N
Summenformel
C8H7ClO
Durchschnittliche Molmasse
154,59 g/mol
Monoisotopische Masse
154,01854252

Überblick

Phenylacetyl chloride appears as a colorless volatile liquid with a strong odor. Denser than water. Contact may severely irritate skin, eyes and mucous membranes. May be toxic by ingestion. May also be combustible.

Namen und Bezeichner

Bevorzugter Name
Phenylacetyl chloride
IUPAC
2-phenylacetyl chloride
Lokaler Name
Phenylacetylchlorid
Englischer Name
Phenylacetyl chloride
Summenformel
C8H7ClO
Molmasse
154.59

Namen und Synonyme

PHENYLACETYL CHLORIDEBenzeneacetyl chloride2-phenylacetyl chloridePhenacetyl chloridePhenylacetic acid chlorideAcetyl chloride, phenyl-UN2577PHENYLACETIC CHLORIDEEINECS 203-146-5UNII-T30899DRND.alpha.-Phenylacetyl chlorideCCRIS 8623
Weitere Namen anzeigen
phenylacetyl-Toluylchloride-ToluylchlorideA-TOLUYL CHLORIDEAKOS BBS-00003909ylacetyl chloridePhenyl acetyl chlori
T30899DRNDAI3-23871DTXSID6059281UN 2577UN-2577alpha-Phenylacetyl chloride2Phenylacetyl chlorideCloruro de fenilacetilo

Datenbank-Bezeichner

CAS
103-80-0
PubChem CID
7679
DTXSID
DTXSID6059281
UNII
T30899DRND
EC Number
203-146-5
Nikkaji
J5.021K

Eigenschaften

Berechnete Struktureigenschaften

XLogP
2,4
Polarare Oberfläche (TPSA)
17,1 Ų
H-Brücken-Donoren
0
H-Brücken-Akzeptoren
1
Frei drehbare Bindungen
2
Schwere Atome
10

Experimentelle und physikochemische Eigenschaften

Chemical Classes · 2 Einträge

Toxic Gases & Vapors -> Acid Halides

Corrosives

SpringerMaterials PropertiesBoiling point
Physical Description · 2 Einträge

Phenylacetyl chloride appears as a colorless volatile liquid with a strong odor. Denser than water. Contact may severely irritate skin, eyes and mucous membranes. May be toxic by ingestion. May also be combustible.

Colorless liquid with a strong odor; [CAMEO] Clear light yellow liquid; [Sigma-Aldrich MSDS]

Physikochemische Eigenschaften

Schmelzpunkt
264 · 264-266 °C(Solv: N,N-dimethylformamide (68-12-2))
Siedepunkt
94 · 94-95 °C/12 mmHg (lit.)
Dichte
1.169 g/mL · 1.169 g/mL at 25 °C (lit.)
Brechungsindex
20 · n20/D 1.5325(lit.)
Flammpunkt
217 °F · 217 °F
storage temp.
2 · 2-8°C

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 4 Einträge

Danger

H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

P260, P261, P264, P271, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P319, P321, P363, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 65 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Gefahrenhinweise

Regulatory Information · 4 Einträge

Chemical: Benzeneacetyl chloride

Status: Active Update: 05-02-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/20430

Phenylacetyl chloride: Does not have an individual approval but may be used under an appropriate group standard

The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)

Other Safety InformationIMAP assessments - Benzeneacetyl chloride: Human health tier I assessment
DOT LabelCorrosive
Fire Hazards · 2 Einträge

Excerpt from ERG Guide 156 [Substances - Toxic and/or Corrosive (Combustible / Water-Sensitive)]:

· Combustible material: may burn but does not ignite readily.

Health Hazards · 2 Einträge

Excerpt from ERG Guide 156 [Substances - Toxic and/or Corrosive (Combustible / Water-Sensitive)]:

· TOXIC and/or CORROSIVE; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death.

Hazards Summary · 1 Eintrag

Fumes in air; Decomposed by water evolving hydrogen chloride gas; May cause severe skin, eye, and mucous membrane irritation; [CAMEO] Causes burns; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; [Sigma-Aldrich MSDS] See Acetyl chloride.

Sicherheit und Schutzausrüstung

Fire FightingExcerpt from ERG Guide 156 [Substances - Toxic and/or Corrosive (Combustible / Water-Sensitive)]:
Accidental Release Measures · 2 Einträge

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

First Aid · 2 Einträge

Excerpt from ERG Guide 156 [Substances - Toxic and/or Corrosive (Combustible / Water-Sensitive)]:

General First Aid:

Exposure Control and Personal Protection· Wear positive pressure self-contained breathing apparatus (SCBA).
Nonfire Spill ResponseExcerpt from ERG Guide 156 [Substances - Toxic and/or Corrosive (Combustible / Water-Sensitive)]:
Isolation and Evacuation · 2 Einträge

Excerpt from ERG Guide 156 [Substances - Toxic and/or Corrosive (Combustible / Water-Sensitive)]:

Immediate precautionary measure

Toxikologische Informationen

Adverse EffectsDermatotoxin - Skin burns.

Sicherheitsdaten

F
21
wgk
3
tsca
TSCA listed
ridadr
UN 2577
hs_code
29163900
risk_code
34-37-14

Chemie und Industrie

Verwendung und Herstellung

UsesUsed in laboratories and to make esters for flavorings; [REPROTOX]
General Manufacturing InformationBenzeneacetyl chloride: ACTIVE
Anwendungen · 1 Eintrag

VerwendenPhenylacetyl chloride is used in the preparation of 1,2-diphenyl-ethanone by reaction with iodobenzene using tetrabutylammonium tetrafluoroborate as a phase transfer catalyst. It is widely used in the chemical industry for manufacturing dyes and pharmaceutical products. It plays an important role in the preparation of penicillin. Further, it is used to prepare esters for flavorings.

Anbieter50 Anbieter

国药集团化学试剂有限公司86-21-63210123 · [email protected]
湖北蝶化新材料科技有限公司86-18372897-544 18995560451
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
Changzhou Carman Chemical Co., Ltd.15061933924

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