2-Isopropoxy-ethanol

0.05

0.05

MILD ETHEREAL ODOR

Mild, ethereal odor.

0.91 (USCG, 1999) - Less dense than water; will float

0.9030 @ 20 °C/4 °C

Relative density (water = 1): 0.903 (20 °C)

0.90

COLORLESS LIQUID

Colorless liquid.

Miscible (NIOSH, 2024)

SOL IN ALL PROP IN WATER, ALC, ETHER; SOL IN ACETONE

Solubility in water, g/100ml at 25 °C: 100

Miscible

91.4 °F (USCG, 1999)

33 °C

92 °F (33 °C) OC

44 °C c.c.

(oc) 92 °F

285.8 °F at 760 mmHg (USCG, 1999)

144 °C @ 743 MM HG

at 99kPa: 139.5-144.5 °C

283 °F

Warning

H312: Harmful in contact with skin [Warning Acute toxicity, dermal]

P261, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P317, P321, P337+P317, P362+P364, and P501 (click each P-code to see the statement)

This chemical does not meet GHS hazard criteria for 0.2% (1 of 648) of reports.

Warning

H226 (41.7%): Flammable liquid and vapor [Warning Flammable liquids]

Chemical: Ethanol, 2-(1-methylethoxy)-

Status: Active Update: 07-09-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/12659

Ethanol, 2-(1-methylethoxy)-: HSNO Approval: HSR001158 Approved with controls

The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)

Special Hazards of Combustion Products: Emits toxic fumes when heated upon decomposition. (USCG, 1999)

Flammable. Above 44 °C explosive vapour/air mixtures may be formed.

ETHYLENE GLYCOL ISOPROPYL ETHER acts both as an alcohol and ether. May react violently with strong oxidizing agents. May generate flammable and/or toxic gases with alkali metals, nitrides, and other strong reducing agents. May initiate the polymerization of isocyanates and epoxides.

Fire Extinguishing Agents: Water, carbon dioxide, dry chemical, alcohol foam. (USCG, 1999)

Use water spray, powder, foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.

Fresh air, rest.

Remove contaminated clothes. Rinse skin with plenty of water or shower.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Give one or two glasses of water to drink.

Excerpt from NIOSH Pocket Guide for 2-Isopropoxyethanol:

(General first aid procedures)

Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Remove all ignition sources. Ventilation. Collect leaking and spilled liquid in sealable containers as far as possible.

SEE ETHERS. ONLY ELECTRICAL EQUIPMENT OF EXPLOSION-PROOF TYPE (GROUP C CLASSIFICATION) IS PERMITTED TO BE OPERATED IN ETHER AREAS. /ETHERS/

...ADVISABLE TO PROTECT PERSONNEL BY ENCLOSING PROCESS OR PROVIDING LOCAL EXHAUST VENTILATION. MAIN HAZARD...THAT OF INGESTION, CAN USUALLY BE PREVENTED BY KEEPING /CHEM/ IN PROPERLY LABELLED CONTAINERS. /GLYCOL & DERIV/

The worker should immediately wash the skin when it becomes contaminated.

Work clothing that becomes wet should be immediately removed due to its flammability hazard.

The substance can be absorbed into the body by inhalation of its vapour and through the skin.

inhalation, skin absorption, ingestion, skin and/or eye contact

Cough.

MAY BE ABSORBED! Redness.

Redness. Pain.

Nausea.

In Animals: irritation eyes, skin; hematuria (blood in the urine), anemia, pulmonary edema

SYMPTOMATOLOGY: 1. CENTRAL NERVOUS DEPRESSION CHARACTERIZED BY TRANSIENT EXHILARATION, DRUNKENNESS, ATAXIA, VERTIGO PROGRESSING TO STUPOR &...COMA, WITH OR WITHOUT TRANSIENT PERIOD OF CONVULSIONS. DEATH FROM RESP ARREST OR...CARDIOVASCULAR COLLAPSE... /ETHYLENE GLYCOL/

SYMPTOMATOLOGY: 2. NAUSEA, VOMITING, ABDOMINAL PAIN, DEHYDRATION, WEAKNESS, MUSCLE TENDERNESS. 3. HYPERPNEA MAY INDICATE EITHER SEVERE METABOLIC ACIDOSIS OR PULMONARY EDEMA. 4. ...CARPOPEDAL SPASM OR OTHER SIGNS OF HYPOCALCEMIC TETANY. /ETHYLENE GLYCOL/

SYMPTOMATOLOGY: 5. LUMBAR PAIN, ALBUMINURIA, HEMATURIA, OLIGURIA PROGRESSING TO ANURIA. 6. ACUTE RENAL FAILURE WITH UREMIA, PERIPHERAL EDEMA, ASCITES, PULMONARY EDEMA, DROWSINESS, CYANOSIS, COMA, & DEATH IN 7 TO 10 DAYS. /ETHYLENE GLYCOL/

SEE GLYCOLS. THERE IS SOME EVIDENCE THAT THE GLYCOL ETHERS ARE MORE TOXIC THAN OTHER MEMBERS OF THE GLYCOL GROUP. /GLYCOLS/

For more Human Toxicity Excerpts (Complete) data for ISOPROPOXYETHANOL (7 total), please visit the HSDB record page.

THE MATERIAL IS APPRECIABLY IRRITATING TO EYES OF RABBITS CAUSING INJURY TO CONJUNCTIVAL MEMBRANES, CORNEA, &...SOME IRITIS. HEALING APPEARED TO BE COMPLETE WITHIN A WEEK.

THE MATERIAL IS NOT APPRECIABLE IRRITATING TO THE SKIN UNDER ORDINARY CONDITIONS OF EXPOSURE, BUT IF IT IS CONFINED FOR PROLONGED PERIODS, IT MAY CAUSE APPRECIABLE IRRITATION, EVEN A BURN. ...THE MATERIAL MAY READILY BE ABSORBED THROUGH THE INTACT SKIN IN LETHAL AMT.

FOUR/FOUR RATS DIED DURING 7 HR OF EXPOSURE TO VAPORS AT ESSENTIALLY SATURATED CONCN, AT 100 °C & COOLED TO ROOM TEMP. AFTER 3 HR, BLOOD APPEARED IN URINE; 1 RAT AUTOPSIED AFTER EXPOSURE HAD BLACK & SEVERELY ENLARGED KIDNEYS. /FROM TABLE/

TWO/THREE RATS DIED DURING 4 HR OF EXPOSURE TO VAPORS AT ESSENTIALLY SATURATED CONCN. BLOODY URINE WAS PASSED IMMEDIATELY AFTER EXPOSURE. THERE WAS EXCESS URINE. THREE DAYS AFTER EXPOSURE THE KIDNEYS WERE SEVERELY NECROTIC AND DARK IN COLOR. /FROM TABLE/

For more Non-Human Toxicity Excerpts (Complete) data for ISOPROPOXYETHANOL (10 total), please visit the HSDB record page.

NO REPORTS OF ADVERSE EFFECTS FROM THE HANDLING OR USE OF ETHYLENE GLYCOL MONOISOPROPYL ETHER HAVE BEEN MADE. ...THIS MAY BE BECAUSE OF ITS LIMITED USE TO DATE.

...NO DATA AVAILABLE THAT WOULD ALLOW THE ESTABLISHMENT OF A HYGIENIC STANDARD FOR REPEATED EXPOSURE TO VAPORS. IN VIEW OF HIGH TOXICITY.../TO/ ANIMALS, IT WOULD SEEM...PRUDENT TO TAKE PARTICULAR CARE TO PREVENT ALL POSSIBLE EXPOSURE OF HUMAN BEINGS TO THIS MATERIAL...

THE MATERIAL MAY READILY BE ABSORBED THROUGH THE INTACT SKIN...

WITHIN 24 HR AFTER (14)C-LABELED ISOPROPYL OXITOL (0.993 MG, IP) ADMIN 71% OF THE RADIOACTIVITY HAD BEEN EXCRETED IN THE URINE & 9% IN THE EXPIRED AIR.

Used as a solvent, particularly in paints and lacquers; [ACGIH]

Painting (Solvents) [Category: Paint]

COMPONENT OF LACQUERS & OTHER COATINGS; AS SOLVENT FOR RESINS; DYES FOR TEXTILES

...MONOALKYL ETHERS ARE USUALLY PRODUCED BY REACTING ETHYLENE OXIDE WITH ALCOHOL OF CHOICE.../OR/ BY DIRECT ALKYLATION OF...GLYCOL WITH AN ALKYLATING AGENT...AB BOESE JR ET AL IN GURME & JOHNSTON, EDITORS, GLYCOLS (AMER CHEM SOC MONOGRAPH, SERIES 114) REINHOLD, NY, 1952.

Ethanol, 2-(1-methylethoxy)-: ACTIVE

IN THE PRESENCE OF GLUCOSE, 10% 2-ISOPROPOXYETHANOL PREVENTED SPORE GERMINATION & MYCELIAL GROWTH OF C RESINAE, A PROBLEM ORGANISM IN JET FUEL.