2-(2-Methoxyethoxy)ethanol

Slight or pleasant smell /Solvents/

Ether-like odor

1.025 at 68 °F (USCG, 1999) - Denser than water; will sink

1.035 g/cu cm at 20 °C

Relative density (water = 1): 1.04

1.025

1.04 @ 20°C

Colorless liquid

Water-white liquid

Light yellow clear liquid

greater than or equal to 100 mg/mL at 66 °F (NTP, 1992)

Miscible /1X10+6 mg/L/ with water

Miscible with alcohol, glycerol, ether, acetone, dimethylformamide

Very soluble in ethanol, ethyl ether

SOL IN ALL PROPN IN BENZENE

Solubility in water: very good

200 °F (NTP, 1992)

205 °F (96 °C) (open cup)

93 °C o.c.

200 °F

Danger

H360D: May damage the unborn child [Danger Reproductive toxicity]

P203, P280, P318, P405, and P501 (click each P-code to see the statement)

Warning

H312 (11%): Harmful in contact with skin [Warning Acute toxicity, dermal]

P203, P264+P265, P280, P302+P352, P305+P351+P338, P317, P318, P321, P337+P317, P362+P364, P405, and P501 (click each P-code to see the statement)

Chemical: Ethanol, 2-(2-methoxyethoxy)-

Hazard Traits - Reproductive Toxicity; Respiratory Toxicity

Ethanol, 2-(2-methoxyethoxy)- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Ethanol, 2-(2-methoxyethoxy)- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 11-10-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/14383

Restricted substance: 2-(2-methoxyethoxy)ethanol (DEGME)

Diethylene glycol monomethyl ether: Does not have an individual approval but may be used under an appropriate group standard

This chemical is combustible. (NTP, 1992)

Combustible. Above 93 °C explosive vapour/air mixtures may be formed.

Combustible

Combustible when exposed to heat or flame; can react with oxidizing materials

Defats the skin; Can be absorbed through the skin; Animal tests show that this substance possibly causes toxicity to human reproduction or development. [ICSC] Labeled as May impair fertility and May cause harm to the unborn child by EU regulations; [Glycol Ethers Online] Readily oxidizes in air forming unstable peroxides that can spontaneously explode; May cause eye irritation; [CAMEO] An irritant; [MSDSonline] See GLYCOL ETHERS.

Miller RR; Metabolism and Disposition of Glycol Ethers; Drug Metab Rev 18 (1): 1-22 (1987).

Johanson G; Aspects of biological monitoring of exposure to glycol ethers; Toxicol Lett 43 (1-3): 5-21 (1988)

European Chemicals Bureau; IUCLID Dataset, 2-(2-Methoxyethoxy)ethanol (111-77-3) (2000 CD-ROM edition).[Available from, as of February 26, 2007: http://esis.jrc.ec.europa.eu/]

Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. Diethylene glycol monomethyl ether is included on this list. Effective date: 4/13/89; Sunset date: 12/19/95.

Fire Extinguishing Agents: Water, carbon dioxide, or dry chemical (USCG, 1999)

Use water spray, powder, alcohol-resistant foam, carbon dioxide.

Fresh air, rest.

Remove contaminated clothes. Rinse skin with plenty of water or shower.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Wear self contained breathing apparatus for fire fighting if necessary.

Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Use water spray to cool unopened containers.

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Store under inert gas. Hygroscopic.

STORAGE: Protect from ignition sources. Keep tanker or tote tightly closed. Do not store in a manner that might adversely effect tote or tanker's integrity. /Phillips Fuel Additive 56 MB/

Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas.

Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations ... Keep in suitable, closed containers for disposal.

Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

SMALL SPILLS AND LEAKAGE: If you should spill this chemical, use absorbent paper to pick up all liquid spill material. Seal the absorbent paper, as well as any of your clothing which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Wash any surfaces you may have contaminated with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.

Product: This combustible material may be burned in a chemical incinerator equipped with an afterburner and scrubber. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material.

Contaminated packaging: Dispose of as unused product.

PESTICIDE DISPOSAL: Pesticide wastes are toxic. Improper disposal of excess pesticide, spray mixture, or rinsate is a violation of Federal law. If these wastes cannot be disposed of by use according to label instructions, contact your State Pesticide or Environmental Control Agency, or the Hazardous Waste Representative at the nearest EPA RegionalOffice of guidance. /Phillips Fuel Additive 56MB/

SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants. Ensure that the local ventilation moves the contaminant away from the worker.

Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

If ... materials are agitated or heated, or if skin contact is extensive and prolonged, it is advisable to protect personnel by enclosing process or providing local exhaust ventilation. Skin and eye protection should also be worn if possibility of such contact exists. /Glycols and deriv/

Avoid contact with skin and eyes. Avoid inhalation of vapor or mist. Keep away from sources of ignition - No smoking. Take measures to prevent the build up of electrostatic charge.

LC50; Species: Lepomis macrochirus (bluegill sunfish); Conditions; static bioassay in fresh water at 23 °C, mild aeration applied after 24 hr; Concentration: 7500 ppm for 96 hr

LC50; Species: Lepomis macrochirus (bluegill sunfish); Conditions: /static bioassay/; Concentration: 9000 mg/L for 24 hr

LC50; Species: /Oncorhynchus mykiss/ (rainbow (steelhead) trout); Concentration: 1000 mg/L for 96 hr /conditions of bioassay not specified/

LC50; Species: Pimephales promelas (fathead minnow); Concentration: 5741 mg/L for 96 hr; /Conditions of bioassay not specified in source examined/

For more Ecotoxicity Values (Complete) data for DIETHYLENE GLYCOL MONOMETHYL ETHER (6 total), please visit the HSDB record page.

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 1(SRC), determined from a structure estimation method(2), indicates that diethylene glycol monomethyl ether is expected to have very high mobility in soil(SRC). Volatilization of diethylene glycol monomethyl ether from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.6X10-11 atm-cu m/mole(SRC), using a fragment constant estimation method(2). Diethylene glycol monomethyl ether is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 0.25 mm Hg at 25 °C(3). Aqueous screening test data suggest that biodegradation may be an important removal mechanism of diethylene glycol monomethyl ether in soil: theoretical BOD losses of 0, 21 and 66% when incubated at 20 °C for 5, 10 and 20 days, respectively, were reported(4).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 1(SRC), determined from a structure estimation method(2), indicates that diethylene glycol monomethyl ether is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 1.6X10-11 atm-cu m/mole(SRC), developed using a fragment constant estimation method(2). Diethylene glycol monomethyl ether is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(3). According to a classification scheme(4), an estimated BCF of 3(SRC), from an estimated log Kow of -1.18(2) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Aqueous screening test data suggest that biodegradation may be an important removal mechanism of diethylene glycol monomethyl ether: theoretical BOD losses of 0, 21 and 66% when incubated at 20 °C for 5, 10 and 20 days, respectively, were reported(5).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), diethylene glycol monomethyl ether, which has a vapor pressure of 0.25 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase diethylene glycol monomethyl ether is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 13 hours(SRC), calculated from its rate constant of 2.6X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Alcohols and ethers do not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, diethylene glycol monomethyl ether is not expected to be susceptible to direct photolysis by sunlight(SRC).

EPA has released the first beta version (version 0.5) of the Interactive Chemical Safety for Sustainability (iCSS) Dashboard. The beta version of the iCSS Dashboard provides an interactive tool to explore rapid, automated (or in vitro high-throughput) chemical screening data generated by the Toxicity Forecaster (ToxCast) project and the federal Toxicity Testing in the 21st century (Tox21) collaboration. /The title compound was tested by ToxCast and/or Tox21 assays; See the data in Chemical Explorer/[USEPA; ICSS Dashboard Application; Available from, as of March 28, 2014: http://actor.epa.gov/dashboard/]

The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical.[Available from, as of February 24, 2014: http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=111-77-3]

From a National Survey, diethylene glycol monomethyl ether was detected in 1 of 21 industrial categories of wastewater effluents(1). Wastewater from the paint and ink industries contained diethylene glycol monomethyl ether at an average of 3,571 mg/L(1). Diethylene glycol monomethyl ether was listed as a volatile emission of glycol ether production(2). Diethylene glycol monomethyl ether was detected, not quantified, in 2 of 44 emission samples from furniture(3). Diethylene glycol monomethyl ether was found as a volatile given off of paint removers(4-5) and in disperse colorants(5).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of diethylene glycol monomethyl ether can be estimated to be 1(SRC). According to a classification scheme(2), this estimated Koc value suggests that diethylene glycol monomethyl ether is expected to have very high mobility in soil.

The in vitro absorption of 2-(2-methoxyethoxy)ethanol through human skin was evaluated. The test substance as a neat liquid was left in contact with the skin for approximately 8 hours. Within 1 hour of skin contact a steady rate of penetration was observed. The mean steady rate of absorption for 2-(2-methoxyethoxy)ethanol was 0.21mg/cm(2)/hour. No significant irreversible alterations to the barrier properties of the epidermal /layer/ were observed.

Acute oral toxicity was evaluated in 4 groups of 10 male albino Wistar rats administered single doses of Poly Solv DM (diethylene glycol monomethyl ether) by gavage at dose levels of 5.0, 7.12, 10.14, and 14.43 g/kg. One mortality was observed at the 10.14 g/kg dose level and 3 mortalities were observed at the 14.43 g/kg dose level within 14 days of dosing. The LD50 was calculated to be greater than 14.43 g/kg (95% confidence), using the Litchfield and Wilcoxon method. Clinical observations include piloerection at the 7.12 g/kg dose level and slight lethargy at both higher dose levels. Gross necropsy revealed dark lungs at the 5.0, 7.12 and 10.14 g/kg dose levels; red intestines at the 10.14 and 14.43 g/kg dose levels; mottled liver at the 5.0 and 7.12 g/kg dose levels; dark and enlarged spleen at the 5.0 g/kg dose level.

Acute oral toxicity was evaluated using 5 groups of 5 Charles River COBS male rats administered diethlyene glycol monomethyl ether by gavage (dose levels not reported). Mortality occurred within 14 days after dosing, but the LD50 value was not reported. Clinical observations included inactivity, labored breathing, rapid respiration, anorexia, slight to moderate weakness, tremors and prostration. Gross necropsy of animals dying within 14 days of dosing revealed bloody urine, and blood in the stomach and intestine. These conditions were not observed in animals surviving through 14 days.

Acute oral toxicity was evaluated using 5 groups of 5 Charles River COBS CD-1 male mice administered diethlyene glycol monomethyl ether by gavage (dose levels not reported). Mortality occurred within 14 days after dosing, but the LD50 value was not reported. Clinical observations included inactivity, labored breathing, rapid respiration, anorexia, slight to moderate weakness, tremors and prostration. Gross necropsy of animals dying within 14 days of dosing revealed bloody urine. This condition was not observed in animals surviving through 14 days.

For more TSCA Test Submissions (Complete) data for DIETHYLENE GLYCOL MONOMETHYL ETHER (22 total), please visit the HSDB record page.

/HUMAN EXPOSURE STUDIES/ ... Diethylene glycol methyl ether at a concentration of 20% in petrolatum when applied as a closed patch test for 48 hours caused no irritation or sensitization in 25 human subjects.

/SIGNS AND SYMPTOMS/ B. 1. Central nervous depression ... 2. No hypocalcemic tetany or metabolic acidosis ... 3. Nausea, vomiting, and sometimes diarrhea. 4. ... Headache. Later abdominal and lumbar pain and costovertebral angle tenderness. 5. Transient polyuria and then oliguria, progressing to anuria. 6. Acute renal failure ... 7. Pathological lesions may appear in brain, lung, liver, meninges and heart. 8. Observations in animals suggest remote possibility of pulmonary edema, intravascular hemolysis and bone marrow depression ... . /Diethylene glycol/

/CASE REPORTS/ Retrocaval ureter is a very rare condition. In light of the experimental studies, one of the etiologic factors seems to be maternal contact with diethylene glycol monomethyl ether or ethylene glycol monomethyl ether. A case of cardiovascular, skeletal, and retrocaval ureter anomalies caused by possible maternal contact while pregnant with these materials at her work in a textile factory is presented.

/SURVEILLANCE/ /The aim is/ to study health effects in hospital cleaners (N = 21) at floor polish removal and application. The cleaners were investigated before exposure (Monday = day 1), after polish removal work (day 2), and after application of floor polish (day 3). Ratings of symptoms, tear-film break-up-time (BUT), nasal patency and biomarkers in nasal lavage were studied. There was a significant increase both day 2 and day 3, as compared to pre-exposure, in ocular, nasal, throat symptoms, solvent smell, dyspnea, and general symptoms such as headache and fatigue. Posterior nasal patency was decreased day 2 (p < 0.01) and day 3 (p < 0.01). No change of nasal biomarkers (eosinophil cationic protein (ECP), myeloperoxidase (MPO), lysozyme, albumin) was seen. BUT was decreased after polish removal (p < 0.01), but not after polish application. Separate test of the weekday effect in non-exposed showed slight improvements, or no change of symptoms or clinical signs from Monday to Wednesday. Air concentrations of ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monoethyl ether, dipropylene glycol monomethyl ether, diethylene glycol monoethyl ether and ethylene glycol phenyl ether 103, 666, 13,650, 7,000, 67, and 27 ug/cu m, respectively, at polish application. Glycol ether levels were reduced to 3% after 2 days and 0.3% after 17 days. Emissions from a common water-based polish remover and floor polish system may cause ocular and airway irritation and general symptoms, and reduce tear-film stability and nasal patency. The levels of glycol ethers had a rapid decay.

For more Human Toxicity Excerpts (Complete) data for DIETHYLENE GLYCOL MONOMETHYL ETHER (7 total), please visit the HSDB record page.

Diethylene glycol monomethyl ether's production and use as an additive in jet fuel, diesel fuels, marine fuels, and fuel oils for anti-microbial control of fungi and bacteria found in hydrocarbon fuel systems and/or for anti-icing control(1), a brake fluid component, a solvent used in paints, printing inks, resins, waxes, and dyes(2) may result in its release to the environment through various waste streams(SRC); it's use as a bacteriostat and as an inert ingredient in formulated pesticide products will result in its direct release to the environment(3).

Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. Diethylene glycol monomethyl ether is included on this list. Effective date: 4/13/89; Sunset date: 12/19/95.

Residues of diethylene glycol monomethyl ether are exempted from the requirement of a tolerance when used in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops only. Use: Deactivator for formulations used before crop emerges from soil, stabilizer.

This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Diethylene glycol monomethyl ether is produced, as an intermediate or final product, by process units covered under this subpart.

...Male Sprague-Dawley rats were given 0.051, or 5.1 mmol/kg (14)C labeled bis(2-methoxyethyl)ether orally. The principal urinary metabolites were (2-methoxyethoxy)acetic acid and methoxyacetic acid which accounted for around 70 and 6% of the doses, respectively. Smaller amounts of N-(methoxyacetyl)glycine, diglycolic acid, 2-methoxyethanol, and 2-(2-methoxyethoxy)ethanol were found. Only unchanged bis(2-methoxyethyl)ether was found in the volatile organic fraction of the expired air. ...Bis(2-methoxyethyl)ether metabolism proceeds primarily through an O-demethylation pathway, followed by oxidation to (2-methoxyethoxy)acetic acid. The lack of toxicity of 2-(2-methoxyethoxy)ethanol and (2-methoxyethoxy)acetic acid suggests that the testicular toxicity of bis(2-methoxyethyl)ether may be due to methoxyacetic acid, a minor metabolite.

... /It is/ absorbed by skin ... .

... Material can be absorbed through skin of rabbits in toxic amounts... .

To assist evaluation of the hazards of skin contact with selected undiluted glycol ethers, their absorption across isolated human abdominal epidermis was measured in vitro. Epidermal membranes were set up in glass diffusion cells and, following an initial determination of permeability to tritiated water, excess undiluted glycol ether was applied to the outer surface for 8 hr. The appearance of glycol ether in an aqueous receptor phase bathing the underside of the epidermis was quantified by a gas chromatographic technique. A final determination of tritiated water permeability was compared with initial values to establish any irreversible alterations in epidermal barrier function induced by contact with the glycol ethers. 2-methoxyethanol (EM) was most readily absorbed (mean steady rate 2.82 mg/sq cm/hr), and a relatively high absorption rate (1.17 mg/sq cm/hr) was also apparent for 1-methoxypropan-2-ol (PM). There was a trend of reducing absorption rate with increasing molecular weight or reducing volatility for monoethylene glycol ethers (EM, 2.82 mg/sq cm/hr; 2-ethoxyethanol, EE, 0.796 mg/sq cm/hr; 2-butoxyethanol, EB, 0.198 mg/sq cm/hr) and also within the diethylene glycol series: 2-(2-methoxyethoxy) ethanol (DM, 0.206 mg/sq cm/hr); 2-(2-ethoxyethoxy) ethanol (DE, 0.125 mg/sq cm/hr) and 2-(2-butoxyethoxy) ethanol (DB, 0.035 mg/sq cm/hr). The rate of absorption of 2-ethoxyethyl acetate (EEAc) was similar to that of the parent alcohol, EE. Absorption rates of diethylene glycol ethers were slower than their corresponding monoethylene glycol equivalents. Combination of intrinsic toxicity and ability to pass across skin contribute to assessment of hazards of contact with undiluted glycol ethers.

The toxicity of bis(2-methoxyethyl)ether was studied in rats. Male Sprague-Dawley rats were given 0.051, or 5.1 mmol/kg (14)C labeled bis(2-methoxyethyl)ether orally. The principal urinary metabolites were (2-methoxyethoxy)acetic acid and methoxyacetic acid which accounted for around 70 and 6% of the doses, respectively. Smaller amounts of N-(methoxyacetyl)glycine, diglycolic acid, 2-methoxyethanol, and 2-(2-methoxyethoxy)ethanol were found. Only unchanged bis(2-methoxyethyl)ether was found in the volatile organic fraction of the expired air. Additionally, rats were given up to 20 daily doses of 5.1 mmol/kg 2-(2-methoxyethoxy)ethanol or (2-methoxyethoxy)acetic acid at on days 3 through 21. 2-(2-Methoxyethoxy)ethanol and (2-methoxyethoxy)acetic acid induced no gross or histopathological testicular changes. Bis(2-methoxyethyl)ether metabolism proceeds primarily through an O-demethylation pathway, followed by oxidation to (2-methoxyethoxy)acetic acid. The lack of toxicity of 2-(2-methoxyethoxy)ethanol and (2-methoxyethoxy)acetic acid suggests that the testicular toxicity of bis(2-methoxyethyl)ether may be due to methoxyacetic acid, a minor metabolite.

Used as a solvent for wood stains, lacquers, inks, textile dye pastes, paints, waxes, dyes, and nitrocellulose resins; Also used in brake fluid, aviation fuel anti-icing additive, and inert ingredient in pesticides; [HSDB] Used as an intermediate; [Hawley] Not produced commercially in the EU; [Glycol Ethers Online]

Painting (Solvents) [Category: Paint]

For diethylene glycol monomethyl ether (USEPA/OPP Pesticide Code: 042204) ACTIVE products with label matches. /SRP: Registered for use in the U.S. but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./

... Inert (or occasionally active) ingredients in pesticide formulations applied to growing crops only. Use: Deactivator for formulations used before crop emerges from soil, stabilizer.

This additive is for use in liquid hydrocarbon fuels including jet fuel, diesel fuels, marine fuels, and fuel oils for anti-microbial control of fungi and bacteria found in hydrocarbon fuel systems and/or for anti-icing control. /Phillips Fuel Additive 56 MB/

De-icing additive for jet fuel. Solvent for paints, coatings and inks. Deactivator and stabilizer for pesticides.

2023: 55,000,000 - <70,000,000 lb

(1972) 5.75X10+9 GRAMS

(1975) 7.12X10+9 GRAMS

(1983) 1.59X10+10 g /Diethylene glycol esters, ethers, etc/

(2006) 1,612 million lb annual capacity /Glycol ethers/

For more U.S. Production (Complete) data for DIETHYLENE GLYCOL MONOMETHYL ETHER (8 total), please visit the HSDB record page.

Reaction of ethylene oxide and methanol (epoxidation)

Ethylene glycol monoethers are commercially manufactured by reaction of an alcohol with ethylene oxide. /Ethylene glycol monoethers/

Ethylene glycol monoethers are usually produced by reaction of ethylene oxide with the appropriate alcohol. A mixture of homologues is obtained ... The glycol monoethers can be converted to diethers by alkylation with common alkylating agents, such as dimethyl sulfate or alkyl halides ( Williamson synthesis). /Ethylene glycol monoethers/

Phillips Fuel Additive 56 MB (Conocophillips Company): Active Ingredient: Diethylene glycol monomethyl ether 99.7%.

Grade: Technical

Cosmetics product ingredient: Diethylene glycol monomethyl ether (2-(2-methoxyethoxy)ethanol; Methoxydiglycol)

Information on 78 consumer products that contain Methoxydiglycol in the following categories is provided:

Wholesale and Retail Trade

Ethanol, 2-(2-methoxyethoxy)-: ACTIVE

Temperature, pressure, mole ratios of reactants and catalysts are chosen to yield the desired product mix. High ratios of ethylene oxide to alcohol are used to favor production of monoethers of diethylene glycol. /Glycol ethers/