Water → 3-[2-(2-Methoxyethoxy)ethoxy]prop-1-yne

HRID 33264

Reaktionsgleichung

Reaktionsgleichung von HRID 33264
[CH3:1][O:2][CH2:3][CH2:4][O:5][CH2:6][CH2:7][OH:8].Br[CH2:10][C:11]#[CH:12].O>C1COCC1>[CH3:1][O:2][CH2:3][CH2:4][O:5][CH2:6][CH2:7][O:8][CH2:12][C:11]#[CH:10]

Komponenten

5

Edukt 3

HCID 962WaterHCID 7842Propargyl bromideHCID 8134Diethylene Glycol Monomethyl Ether

Produkt 1

HCID 183816833-[2-(2-Methoxyethoxy)ethoxy]prop-1-yne

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of 2 g 2-(2-Methoxy-ethoxy)-ethanol in 20 ml THF 1.8 g KOt-Bu were added at 0° C. After stirring for 10 min 8.1 ml 3-Bromo-propyne (75% in toluene) were added and the mixture was warmed to RT and stirred for 4 h. Then 10 ml of water were added and the mixture was filtered through a chem elut® cartridge by elution with CHCl3. This solution containing the desired product was subjected to the next reaction step.

Aufarbeitung

  1. additionwere added
  2. filtrationthe mixture was filtered through a chem elut® cartridge by elution with CHCl3
  3. additionThis solution containing the desired product
  4. customwas subjected to the next reaction step

Quellen und Nachweise

ORD-Eintrag
ord-d90fa2892b694c848f6f1ca5bfd7cdec
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07429581B2

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