Bistris (HCID 81462)

Überblick

Bis-tris is a buffer substance useful for calibration of glass electrodes and for the preparation of the biochemical and biological buffer solutions; pKa = 6.46 at 25 C. It has a role as a buffer. It is functionally related to a member of tris.

Namen und Bezeichner

Bevorzugter Name: Bistris
IUPAC: 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)propane-1,3-diol
Lokaler Name: 2-[Bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)propan-1,3-diol
Englischer Name: BIS-Tris
Summenformel: C8H19NO5
Molmasse: 209.24

Namen und Synonyme

bis-tris6976-37-0Bistris2,2-Bis(hydroxymethyl)-2,2',2''-nitrilotriethanol2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)propane-1,3-diol2-(Bis(2-hydroxyethyl)amino)-2-(hydroxymethyl)propane-1,3-diolQ1XC3631CPCHEBI:412501,3-Propanediol, 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)-NSC-24868NSC-1199321,3-Propanediol, 2-(bis(2-hydroxyethyl)amino)-2-(hydroxymethyl)-

Weitere Namen anzeigen

BIS(2-HYDROXYETHYL)IMINOTRIS(HYDROXYMETHYL)METHANEBIS(2-HYDROXYETHYL)AMINO-TRIS(HYDROXYMETHYL)METHANEBIS-TRIS BUFFERBIS-HYDROXYETHYL TROMETHAMINEBis-Iris2,2-BIS(HY''BIS-TRIS''BIS-TRIS >99%

2,2-Bis[hydroxymethyl]-2,2',2''-nitrilotriethanolRefChem:569580bis(2-hydroxyethyl)imino-tris(hydroxymethyl)methane2-(bis(2-hydroxyethyl)amino)-2(hydroxymethyl)-1,3-propanediol2,2-BIS(HYDROXYETHYL)-(IMINOTRIS)-(HYDROXYMETHYL)METHANE230-237-7686-880-2Bis(2-hydroxyethyl)aminotris(hydroxymethyl)methane

Datenbank-Bezeichner

CAS: 6976-37-0
PubChem CID: 81462
DTXSID: DTXSID6064537
ChEBI: CHEBI:41250
UNII: Q1XC3631CP
EC Number: 230-237-7、686-880-2
Nikkaji: J135.733F

Eigenschaften

Berechnete Struktureigenschaften

XLogP: -3,3
Polarare Oberfläche (TPSA): 104 Å²
H-Brücken-Donoren: 5
H-Brücken-Akzeptoren: 6
Frei drehbare Bindungen: 8
Schwere Atome: 14
Formalladung: 0
Komplexität: 125

Experimentelle und physikochemische Eigenschaften

Chemical ClassesNitrogen Compounds -> Amino Alcohols, Other

Physical Description · 2 Einträge

Liquid

White crystalline powder; [Sigma-Aldrich MSDS]

Physikochemische Eigenschaften

Schmelzpunkt: 104 °C · 104 °C(lit.)
Siedepunkt: 466.2 · 466.2±40.0 °C(Predicted)
Dichte: 1.346 · 1.346±0.06 g/cm3(Predicted)
Dampfdruck: 0 Pa · 0Pa at 25℃
storage temp.: Inert atmosphere,Room Temperature
Löslichkeit: 2 O: · H2O: 1 M at 20 °C, clear, colorless
Aggregatzustand: Solution
Farbe: Yellow to orange
Geruch (Odor): Odorless
PH: 9 · 9.0-10.1 (20-25℃, 1M in water)
pka: 6.5 · 6.5(at 25℃)
Biologische Quelle: synthetic
Wasserlöslichkeit: soluble
BRN: 2205275 · 2205275
Major Application: diagnostic assay manufacturing
Kosmetik-Inhaltsstoffe Funktionen: BUFFERING
InChI: 1S/C8H19NO5/c10-3-1-9(2-4-11)8(5-12,6-13)7-14/h10-14H,1-7H2
InChIKey: OWMVSZAMULFTJU-UHFFFAOYSA-N
SMILES: OCCN(CCO)C(CO)(CO)CO
LogP: -2.26 at · -2.26 at 20℃
CAS Datenbank: 6976 · 6976-37-0(CAS DataBase Reference)
EPA chemische Informationen: 1 · 1,3-Propanediol, 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)- (6976-37-0)
Absorption: 270 nm · cut-off at 270nm in H2O at 1M

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 6 Einträge

This chemical does not meet GHS hazard criteria for 0.7% (2 of 271) of reports.

Danger

H315 (37.6%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 271 reports by companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Warning

Gefahrenhinweise

Regulatory Information · 4 Einträge

Chemical: 1,3-Propanediol, 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)-

1,3-Propanediol, 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,3-Propanediol, 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 04-01-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/24579

1,3-Propanediol, 2-bis(2-hydroxyethyl)amino-2-(hydroxymethyl)-: Does not have an individual approval but may be used under an appropriate group standard

Hazards SummaryA skin and strong eye irritant; [Sigma-Aldrich MSDS]

Hazard Classes and Categories · 2 Einträge

Skin Irrit. 2 (37.6%)

Skin Irrit. 2 (100%)

Sicherheitsdaten

F: 10-23
wgk: 3
tsca: TSCA listed
hs_code: 29221980
risk_code: 36/37/38-21/22-20/21/22
hazard_code: Xi,Xn
safety_code: 26-36-36/37/39-22
Speicherklasse: 11 - Combustible Solids
Hazard Classifications: Eye Irrit. 2

Chemie und Industrie

Pharmakologische Informationen

MeSH Pharmacological ClassificationA chemical system that functions to control the levels of specific ions in solution. When the level of hydrogen ion in solution is controlled the system is called a pH buffer.

Verwendung und Herstellung

U.S. Production2023: 362,371 lb

Industry UsesNot Known or Reasonably Ascertainable

General Manufacturing Information · 2 Einträge

Pharmaceutical and Medicine Manufacturing

1,3-Propanediol, 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)-: ACTIVE

Anwendungen · 2 Einträge

VerwendenIt is used as a biological buffer, organic synthesize, chemical & pharmaceutical intermediate. It is suitable for fractionation of hemoglobin.

VerwendenBis-Tris, also known as bis-Tris methane, is a zwitterionic buffering agent used in biochemistry and molecular biology. It is a bis(2-hydroxyethyl)amine and Tris family buffer. Bis Tris is a common component of many buffer systems for various types of electrophoresis. Bis-Tris may form a complex with some common metals, such as Cu(II) and Pb(II), and formation constants should be taken into account when using this buffer in a solution containing metal ions. Bis-Tris can be used as a substitute for the highly toxic buffer cacodylate.