Grundinformationen
- CAS
10045-45-1- Standard-SMILES
CCn1c(=O)[nH]c2ccccc21- InChIKey
CXUCKELNYMZTRT-UHFFFAOYSA-N- Summenformel
- C9H10N2O
- Durchschnittliche Molmasse
- 162,19 g/mol
- Monoisotopische Masse
- 162,07931294
Überblick
1-Ethyl-2-benzimidazolinone is a member of imidazoles.
Namen und Bezeichner
- Bevorzugter Name
- 1-Ebio
- IUPAC
- 3-ethyl-1H-benzimidazol-2-one
- Lokaler Name
- 1-Ethylbenzimidazolin-2-on
- Englischer Name
- 1-EBIO
- Summenformel
- C9H10N2O
- Molmasse
- 162.19
Namen und Synonyme
10045-45-11-EBIO1-Ethyl-2-benzimidazolinone3-ethyl-1H-benzimidazol-2-oneM82W79SS4WDTXSID701432961-ethyl-2-benzimidazoloneRefChem:432381DTXCID4065787233-148-11-Ethylbenzimidazolinone1-ethyl-1H-benzo[d]imidazol-2(3H)-one
Weitere Namen anzeigen
1-EB10Einecs 233-148-11-EBIO, 10 mM in DMSO1-ETHYL-2-BENZCMIDAZOLINONE1-Ethyl-2-benzimidazolineone
1-ethyl-1,3-dihydro-2h-benzimidazol-2-one2H-Benzimidazol-2-one, 1-ethyl-1,3-dihydro-1-Ethyl-BenzimidazolinoneEBIO1-Ethylbenzimidazolin-2-oneMFCD00005715CHEMBL4528871-Ethyl-1,3-dihydro-benzoimidazol-2-one
Datenbank-Bezeichner
- CAS
10045-45-1- PubChem CID
- 82320
- DTXSID
DTXSID70143296- ChEMBL
CHEMBL452887- ChEBI
CHEBI:34076- UNII
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 1,1
- Polarare Oberfläche (TPSA)
- 32,3 Ų
- H-Brücken-Donoren
- 1
- H-Brücken-Akzeptoren
- 1
- Frei drehbare Bindungen
- 1
- Schwere Atome
- 12
- Formalladung
- 0
- Komplexität
- 193
Physikochemische Eigenschaften
- Schmelzpunkt
- 118 · 118-120 °C(Solv: ethyl acetate (141-78-6))
- Dichte
- 1.161 · 1.161±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Löslichkeit
- 20 mg/mL · DMSO: ≥20mg/mL
- Aggregatzustand
- powder
- pka
- 12.29 · 12.29±0.30(Predicted)
- Farbe
- Crystalline
- Stabilität
- 1 year · Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P264, P264+P265, P270, P280, P301+P317, P305+P351+P338, P330, P337+P317, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 42 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Hazard Classes and CategoriesAcute Tox. 4 (100%)
Sicherheitsdaten
- wgk
- 3
- hs_code
- 2933998090
- risk_code
- 22-36
- hazard_code
- Xn
- safety_code
- 26
- hazard_class
- IRRITANT
Chemie und Industrie
Pharmakologische Informationen
MeSH Pharmacological Classification
Agents that increase calcium influx into calcium channels of excitable tissues. This causes vasoconstriction in VASCULAR SMOOTH MUSCLE and/or CARDIAC MUSCLE cells as well as stimulation of insulin release from pancreatic islets. Therefore, tissue-selective calcium agonists have the potential to combat cardiac failure and endocrinological disorders. They have been used primarily in experimental studies in cell and tissue culture.
Anwendungen
Beschreibung1-EBIO is an activator of Ca2+-sensitive K+ channels (EC50 = 490 μM in T84 human carcinoma cells).This action is sensitive to the neurotoxin charybdotoxin (Ki = 3.5 nM). In mouse colonic epithelia, 1-EBIO also activates cAMP-sensitive K+ channels, a response this is inhibited by 293B.In this type of epithelium, but not mouse nasal epithelia, 1-EBIO activates both types of channels, resulting in large Cl- secretory currents.It also activates the human intermediate conductance Ca2+-activated K+ channel (EC50 = 74 μM).1-EBIO is currently used to study the role of these types of K+ channels in diverse physiological functions.
Verwenden1-EBIO stimulates Cl- secretion in secretory epithelia through direct activation of clacium potassium channels.1-EBIO was used to study the electrical activity modulated by Ca+2-activated K+ channels in rat central neurons. The effect of 1-EBIO on human intermediate conductance channels was studied.The K+ channel opener 1-EBIO potentiates residual function of mutant CFTR in rectal biopsies from cystic fibrosis patients
Vor- und nachgelagerte Produkte
Vorgelagerte Rohstoffe
Zugehörige Reaktionen
7
Notizen zur Verbindung
Wird geladen…