Phenylsalicylat

insoluble

0.15 mg/mL at 25 °C

insoluble in water; soluble in 50% Heptane

moderately soluble (in ethanol)

172-173

172.00 to 173.00 °C. @ 12.00 mm Hg

172-173 °C (12 mm Hg)

41-43

43 °C

This chemical does not meet GHS hazard criteria for 12.6% (92 of 729) of reports.

Warning

H315 (85.9%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 729 reports by companies from 14 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Chemical: Benzoic acid, 2-hydroxy-, phenyl ester

Commission Regulation (EC) No 1565/2000 (Repealed by Com. Implementing Reg. (EU) No 872/2012)

Benzoic acid, 2-hydroxy-, phenyl ester is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Benzoic acid, 2-hydroxy-, phenyl ester are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 14-07-2017 https://echa.europa.eu/registration-dossier/-/registered-dossier/20078

Benzoic acid, 2-hydroxy-, phenyl ester: Non hazardous

Causes convulsions and decreased body temperature in oral lethal-dose studies of rabbits; [RTECS] Mildly irritating to skin and eyes; [NTP] Safe when used as a flavoring agent in food; [JECFA] A skin and strong eye irritant; [Sigma-Aldrich MSDS] See Methyl salicylate. See Acetylsalicylic acid.

G - Genito urinary system and sex hormones

QG - Genito urinary system and sex hormones

Phenyl salicylate has several medical uses. It can be used as an analgesic to relieve pain, as an antiseptic with antibacterial effect as well as a kind of antipyretic for the treatment of fever. It is also used for the treatment of inflammation in the lower urinary tract. It is no longer commonly applied to human medical practice but is still used in veterinary medicine [MSDS]. When it is combined with methenamine, benzoic acid, phenyl salicylate, methylene blue, and hyoscyamine sulfate, it is used to relieve the discomfort, pain, frequent urge to urinate, and cramps/spasms of the urinary tract caused by a urinary tract infection or a diagnostic procedure.

Hydrolyzed to salicylic acid. Salicylic acid elimination kinetics are dependent on drug concentration because of the limited capacity of two major biotransformation pathways: formation of salicyluric acid and of salicyl phenolic glucuronide. Metabolism of this drug occurs mainly in the liver, like other salicylates. Metabolism of salicylic acid occurs through glucuronide formation (to produce salicyluric acid), and salicyl phenolic glucuronide), conjugation with glycine (to produce salicyluric acid), and oxidation to form gentisic acid. The rate of formation of salicyl phenolic glucuronide and salicyluric acid are easily saturated at low salicylic acid concentrations and their formation can be described by Michaelis-Menten kinetics.

Rapidly absorbed. Refer to [DB00945] for detailed salicylate absorption information.

Please refer to [DB00945] for the route of elimination.

Steady-state plasma salicylate concentrations increase more than proportionally with increasing dosages; the time required to reach steady state increases with increasing daily dose. Dosage intervals of 8-12 h are sufficient to maintain plasma salicylate concentrations in the normal therapeutic anti-inflammatory concentration range.

Please refer to [DB00945] for more information.

Used to make polymers; Also used as a drug (analgesic/antipyretic/anti-inflammatory) and ingredient in lacquers, adhesives, waxes, polishes, suntan products, and plastics (absorbs light and prevents discoloration); [Merck Index] Used as an antioxidant and stabilizer/thickener for foods; [FDA]

Painting (Pigments, Binders, and Biocides) [Category: Paint]

Fragrance Ingredients

Flavouring Agent -> FLAVOURING_AGENT -> JECFA Functional Classes

Flavoring Agents -> JECFA Flavorings Index

Flavouring Agent -> FLAVOURING_AGENT -> JECFA Functional Classes

Cosmetics -> Denaturant; Antimicrobial

Plastics Product Manufacturing

Benzoic acid, 2-hydroxy-, phenyl ester: ACTIVE