HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Nhs-LC-biotin
BIOTIN-X-NHS · Biotin-LC-NHS · NHS-LC-BIOTIN · Bachs · BIOTIN-X, SE · NHS-X-Biotin · D-Biotiamide · BIOTIN-LC-OSU
Identifikatoren & physikalische Daten
| CAS No. | 72040-63-2 |
|---|---|
| Summenformel | C20H30N4O6S |
| Durchschnittliche Molmasse | 454,5 g/mol |
| Monoisotopische Masse | 454,18860568 g/mol |
| SMILES | O=C(CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21)NCCCCCC(=O)ON1C(=O)CCC1=O |
| InChIKey | UVGHPGOONBRLCX-NJSLBKSFSA-N |
| PubChem CID | 83874 |
| EC No. | 615-709-6 |
| DTXSID | DTXSID90992728 |
Chemische & physikalische Eigenschaften
| XLogP | 0,1 |
|---|---|
| Polarare Oberfläche (TPSA) | 159 |
| H-Brücken-Donoren | 3 |
| H-Brücken-Akzeptoren | 7 |
| Frei drehbare Bindungen | 13 |
| Schwere Atome | 31 |
| Formalladung | 0 |
| Komplexität | 702 |
| Schmelzpunkt | 169-171 °C |
| Dichte | 1.35±0.1 g/cm3(Predicted) |
| Lagerbedingungen | -20°C |
| Löslichkeit | H2O: ≤2 mg/mL with sonicationH2O: ≤2mg/mL (with sonication)DMF: 50mg/mL (Stable up to 2 months in dry DMF.) |
| Aggregatzustand | powder |
| pKa (Säurekonstante) | 13.90±0.40(Predicted) |
| Farbe | White to Off-White |
| BRN | 3577403 |
| Stabilität | Moisture Sensitive |
| InChIKey | UVGHPGOONBRLCX-NJSLBKSFSA-N |
| SMILES | C(ON1C(=O)CCC1=O)(=O)CCCCCNC(=O)CCCC[C@H]1[C@@]2([H])NC(=O)N[C@@]2([H])CS1 |
| CAS Datenbank | 72040-63-2(CAS DataBase Reference) |
Sicherheit & Vorschriften
| GHS-Einstufung | WarningH302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory. |
|---|---|
| Hazard Classes and Categories | Acute Tox. 4 (100%) |
| F | 10-21 |
| Wassergefährdungsklasse (WGK) | 3 |
| Zollcode | 29349990 |
| Sicherheitshinweise (S) | 24/25 |
| Lagerklasse | 11 - Combustible Solids |
Anwendungen & Verwendung
Verwenden
Succinimidyl 6-(biotinamido)hexanoate is a biotinylation reagent incorporating an aminocaproyl “spacer”. This can reduce the steric hindrance in binding avidin to some biotinylated compounds when used to biotinylate both the antibody and the carrier in the Protein Avidin-Biotin Capture System. This system avoids the direct interaction of a captured antibody with solid surfaces, such as plastics, which may reduce antigenicity. It has also been used to enhance the detection of DNA on nitrocellulose. Has also been used as a cell surface labelling reagent