Nhs-LC-biotin

HCID 83874CAS 72040-63-2

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Grundinformationen

Standard-SMILES: O=C(CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21)NCCCCCC(=O)ON1C(=O)CCC1=O
InChIKey: UVGHPGOONBRLCX-NJSLBKSFSA-N
Summenformel: C20H30N4O6S
Durchschnittliche Molmasse: 454,5 g/mol
Monoisotopische Masse: 454,18860568

Namen und Bezeichner

Bevorzugter Name: Nhs-LC-biotin
IUPAC: (2,5-dioxopyrrolidin-1-yl) 6-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]hexanoate
Englischer Name: Succinimidyl 6-(biotinamido)hexanoate
Summenformel: C20H30N4O6S
Molmasse: 454.54

Namen und Synonyme

Succinimidyl 6-(biotinamido)hexanoateNhs-LC-biotinRefChem:853804615-709-672040-63-22,5-Dioxopyrrolidin-1-yl 6-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)hexanoateBACHSSuccinimidyl-6-(biotinamido) HexanoateBiotin-X, succinimidyl esterBiotin-C5-NHS EsterMFCD00065502(+)-Biotin-LC-NHS Ester

Weitere Namen anzeigen

BIOTIN-X-NHSBiotin-LC-NHSBIOTIN-X, SENHS-X-BiotinD-BiotiamideBIOTIN-LC-OSUBiotin-NHS LCNHS-Biotin LC

N-Succinimidyl 6-BiotinamidohexanoateSuccinimidyl-6-biotinamide hexanoateBiotinamidohexanoic acid N-hydroxysuccinimide ester(2,5-dioxopyrrolidin-1-yl) 6-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]hexanoateBiotin-amidocaproate-N-hydroxysuccinimide esterBiotinyl-6-aminocaproic acid N-hydroxysuccinimide esterC20H30N4O6SBiotinyl-epsilon-aminohexanoic acid N-hydroxysuccinimide ester

Datenbank-Bezeichner

CAS: 72040-63-2
PubChem CID: 83874
DTXSID: DTXSID90992728
EC Number: 615-709-6
Nikkaji: J671.769A

Eigenschaften

Berechnete Struktureigenschaften

XLogP: 0,1
Polarare Oberfläche (TPSA): 159 Å²
H-Brücken-Donoren: 3
H-Brücken-Akzeptoren: 7
Frei drehbare Bindungen: 13
Schwere Atome: 31
Formalladung: 0
Komplexität: 702

Physikochemische Eigenschaften

Schmelzpunkt: 169 · 169-171 °C
Dichte: 1.35 · 1.35±0.1 g/cm3(Predicted)
storage temp.: -20 °C · -20°C
Löslichkeit: 2 O: · H2O: ≤2 mg/mL with sonication
Aggregatzustand: powder
pka: 13.9 · 13.90±0.40(Predicted)
Farbe: White to Off-White
Wasserlöslichkeit: 2 O: · H2O: ≤2mg/mL (with sonication)DMF: 50mg/mL (Stable up to 2 months in dry DMF.)
BRN: 3577403 · 3577403
Stabilität: Moisture Sensitive
InChIKey: UVGHPGOONBRLCX-NJSLBKSFSA-N
SMILES: C(ON1C(=O)CCC1=O)(=O)CCCCCNC(=O)CCCC[C@H]1[C@@]2([H])NC(=O)N[C@@]2([H])CS1
CAS Datenbank: 72040 · 72040-63-2(CAS DataBase Reference)

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 4 Einträge

Warning

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Gefahrenhinweise

Hazard Classes and CategoriesAcute Tox. 4 (100%)

Sicherheitsdaten

F: 10-21
wgk: 3
hs_code: 29349990
safety_code: 24/25
Speicherklasse: 11 - Combustible Solids

Chemie und Industrie

Anwendungen · 1 Eintrag

VerwendenSuccinimidyl 6-(biotinamido)hexanoate is a biotinylation reagent incorporating an aminocaproyl “spacer”. This can reduce the steric hindrance in binding avidin to some biotinylated compounds when used to biotinylate both the antibody and the carrier in the Protein Avidin-Biotin Capture System. This system avoids the direct interaction of a captured antibody with solid surfaces, such as plastics, which may reduce antigenicity. It has also been used to enhance the detection of DNA on nitrocellulose. Has also been used as a cell surface labelling reagent