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Manganese sulfide (MNS)

HCID 87809
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Grundinformationen

CAS
18820-29-6
Standard-SMILES
[S]=[Mn]
InChIKey
CADICXFYUNYKGD-UHFFFAOYSA-N
Summenformel
MnS
Durchschnittliche Molmasse
87,01 g/mol
Monoisotopische Masse
86,910114

Überblick

Manganese(II) sulfide is a sulfide of manganese. It occurs in nature as the mineral alabandite. Manganese is a naturally occurring metal with the symbol Mn and the atomic number 25. It does not occur naturally in its pure form, but is found in many types of rocks in combination with other substances such as oxygen, sulfur, or chlorine. Manganese occurs naturally in most foods and small amounts are needed to stay healthy, as manganese ions act as cofactors for a number of enzymes. (L228, L229, L237)

Namen und Bezeichner

Bevorzugter Name
Manganese sulfide (MNS)
IUPAC
sulfanylidenemanganese
Englischer Name
Manganese(II) sulfide
Summenformel
MnS
Molmasse
87.003049

Namen und Synonyme

Manganese sulfide18820-29-6Manganese sulfide (MnS)sulfanylidenemanganeseManganous sulfide87Y1S2L575RefChem:155595242-599-3Manganese(II) sulfideManganese(2+) sulfide(Sulfido)manganeseManganese(II) sulfide, ~100 mesh particle size
Weitere Namen anzeigen
UNII-87Y1S2L575EINECS 242-599-3EC 242-599-3SCHEMBL57934MANGANESE SULFIDE [MI]DTXSID00893974Q419893

Datenbank-Bezeichner

CAS
18820-29-6
PubChem CID
87809
DTXSID
DTXSID00893974
UNII
87Y1S2L575
EC Number
242-599-3
Nikkaji
J43.900B

Eigenschaften

Berechnete Struktureigenschaften

Polarare Oberfläche (TPSA)
32,1 Ų
H-Brücken-Donoren
0
H-Brücken-Akzeptoren
1
Frei drehbare Bindungen
0
Schwere Atome
2
Formalladung
0
Komplexität
2

Experimentelle und physikochemische Eigenschaften

Chemical ClassesMetals -> Manganese Compounds, Inorganic
Density4 @25 °C
Melting Point1610 °C
Physical DescriptionPink, green, or brown-green solid; [Merck Index]

Sicherheit und Regulatorisches

Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.

GHS-Klassifizierung

GHS Classification · 5 Einträge

This chemical does not meet GHS hazard criteria for 7.5% (25 of 333) of reports.

Danger

H315 (91%): Causes skin irritation [Warning Skin corrosion/irritation]

P260, P261, P264, P264+P265, P270, P271, P272, P273, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P333+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 333 reports by companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Gefahrenhinweise

Regulatory Information · 3 Einträge

Manganese sulfide (MnS) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Manganese sulfide (MnS) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

REACH registered substance: Manganese sulphide (EC: 242-599-3)

Manganese sulfide (MnS): Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

Hazards SummaryToxic by ingestion; [MSDSonline] See Manganese and linked occupational diseases.
Hazard Classes and CategoriesSkin Irrit. 2 (91%)

Sicherheit und Schutzausrüstung

Exposure Control and Personal Protection0.2 [mg/m3], as Mn (inhalable fraction), 0.02 mg/m3, as Mn (respirable fraction)[German Research Foundation (DFG)]

Chemie und Industrie

Pharmakologische Informationen

Metabolism/Metabolites · 1 Eintrag

Manganese is absorbed mainly via ingestion, but can also be inhaled. It binds to alpha-2-macroglobulin, albumin, or transferrin in the plasma and is distributed to the brain and all other mammalian tissues, though it tends to accumulate more in the liver, pancreas, and kidney. Manganese is capable of existing in a number of oxidation states and is believed to undergo changes in oxidation state within the body. Manganese oxidation state can influence tissue toxicokinetic behavior, and possibly toxicity. Manganese is excreted primarily in the faeces. (L228)

Verwendung und Herstellung

Uses · 2 Einträge

Used as steel additive; [Hawley] Found in the minerals alabandite and manganblende; [Merck Index]

Steel Producing [Category: Industry]

U.S. Production2023: 3,630,000 lb
Consumer UsesNot Known or Reasonably Ascertainable
Industry UsesNot Known or Reasonably Ascertainable
General Manufacturing Information · 2 Einträge

All Other Basic Inorganic Chemical Manufacturing

Manganese sulfide (MnS): ACTIVE

Anbieter100 Anbieter

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Minimum Risk LevelChronic Inhalation: 0.0003 mg/m3 (L134)
Threshold Limit Values (TLV)0.02 [mg/m3], as Mn (respirable fraction), 0.1 mg/m3, as Mn (inhalable fraction)
Protective Action Criteria (PAC) · 3 Einträge

4.8 [mg/m3]

7.9 [mg/m3]

790 [mg/m3]

Toxikologische Informationen

Treatment · 1 Eintrag

EYES: irrigate opened eyes for several minutes under running water. INGESTION: do not induce vomiting. Rinse mouth with water (never give anything by mouth to an unconscious person). Seek immediate medical advice. SKIN: should be treated immediately by rinsing the affected parts in cold running water for at least 15 minutes, followed by thorough washing with soap and water. If necessary, the person should shower and change contaminated clothing and shoes, and then must seek medical attention. INHALATION: supply fresh air. If required provide artificial respiration.

Health Effects · 1 Eintrag

Manganese mainly affects the nervous system and may cause behavioral changes and other nervous system effects, which include movements that may become slow and clumsy. This combination of symptoms when sufficiently severe is referred to as “manganism”. (L228)

Adverse EffectsNeurotoxin - Parkinsonism
Exposure RoutesOral (L228) ; inhalation (L228)
Toxicity Summary · 1 Eintrag

Manganese is a cellular toxicant that can impair transport systems, enzyme activities, and receptor functions. It primarily targets the central nervous system, particularily the globus pallidus of the basal ganglia. It is believed that the manganese ion, Mn(II), enhances the autoxidation or turnover of various intracellular catecholamines, leading to increased production of free radicals, reactive oxygen species, and other cytotoxic metabolites, along with a depletion of cellular antioxidant defense mechanisms, leading to oxidative damage and selective destruction of dopaminergic neurons. In addition to dopamine, manganese is thought to perturbations other neurotransmitters, such as GABA and glutamate. In order to produce oxidative damage, manganese must first overwhelm the antioxidant enzyme manganese superoxide dismutase. The neurotoxicity of Mn(II) has also been linked to its ability to substitute for Ca(II) under physiological conditions. It can enter mitochondria via the calcium uniporter and inhibit mitochondrial oxidative phosphorylation. It may also inhibit the efflux of Ca(II), which can result in a loss of mitochondrial membrane integrity. Mn(II) has been shown to inhibit mitochondrial aconitase activity to a significant level, altering amino acid metabolism and cellular iron homeostasis. (L228)

Signs and Symptoms · 1 Eintrag

Manganese mainly affects the nervous system and may cause behavioral changes and other nervous system effects, which include movements that may become slow and clumsy. This combination of symptoms when sufficiently severe is referred to as “manganism”. (L228)

Carcinogen ClassificationNo indication of carcinogenicity to humans (not listed by IARC).
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