HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HCID 89949Erstellt: 1. November 2026
Abnormal Cannabidiol
ABN-CBD · Abn CBD,AbnCBD · Cannabidiol, Abnormal · Abnormal Cannabidiol (Abn-CBD) · Abn-CBD (Abnormal Cannabidiol) · 1-Hydroxy-3-n-Pentylcannabidiol · 4-(p-Mentha-1,8-dien-3-yl)-5-pentylresorcinol · 8-dien-3-yl-5-pentyl-4-p-mentha-(-)-(e)-resorcino
https://huagongshe.com/de/chemical/89949
Identifikatoren & physikalische Daten
| CAS No. | 22972-55-0 |
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| Summenformel | C21H30O2 |
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| Durchschnittliche Molmasse | 314,5 g/mol |
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| Monoisotopische Masse | 314,2245802 g/mol |
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| SMILES | C=C(C)[C@@H]1CCC(C)=C[C@H]1c1c(O)cc(O)cc1CCCCC |
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| InChIKey | YWEZXUNAYVCODW-RBUKOAKNSA-N |
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| PubChem CID | 89949 |
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| ChEMBL | CHEMBL499876 |
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| ChEBI | CHEBI:197013 |
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| DTXSID | DTXSID10945675 |
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Chemische & physikalische Eigenschaften
| XLogP | 6,5 |
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| Polarare Oberfläche (TPSA) | 40,5 |
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| H-Brücken-Donoren | 2 |
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| H-Brücken-Akzeptoren | 2 |
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| Frei drehbare Bindungen | 6 |
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| Schwere Atome | 23 |
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| Formalladung | 0 |
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| Komplexität | 426 |
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| Endocrine Disruptors | Potential endocrine disrupting compound |
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| Siedepunkt | 446.4±45.0 °C(Predicted) |
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| Dichte | 1.025±0.06 g/cm3(Predicted) |
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| Lagerbedingungen | Desiccate at -20°C |
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| Löslichkeit | Soluble in methyl acetate (supplied pre-dissolved - 5mg/ml) |
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| Aggregatzustand | Powder |
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| pKa (Säurekonstante) | 9.94±0.45(Predicted) |
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Sicherheit & Vorschriften
| Alarmwort | Achtung |
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| Gefahrenhinweise | Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code H225 |
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Anwendungen & Verwendung
Beschreibung
Abnormal cannabidiol is a synthetic cannabidiol agonist of GPR55 (EC50 = 2.5 μM in a GTPγS binding assay). It is selective for GPR55 over cannabinoid (CB) receptor 1 (CB1) and CB2 (EC50s = >30 μM for both in GTPγS binding assays). It is also a full agonist at GPR18, with an EC50 value of 0.835 μM for inducing p44/42 MAPK phosphorylation in HEK293 cells expressing GPR18. Abnormal cannabidiol increases migration of BV-2 microglial cells (EC50 = 0.6 μM). It induces endothelium-dependent vasodilation via a CB1-CB2-NO-independent mechanism and inhibits vasoconstriction induced by endothelin 1 (ET-1; ) in retinal arterioles, an effect that can be blocked by the calcium-sensitive potassium channel blocker apamin . Abnormal cannabidiol also decreases blood pressure in anesthetized rats when administered intravenously at a dose of 20 μg/g or when administered directly into the rostral ventrolateral medulla at 0.4 and 0.8 μg.
