Fluocortolon

Fluocortolone

HCID 9053CAS 152-97-6
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Grundinformationen

Standard-SMILES
C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@]2(C)[C@H]1C(=O)CO
InChIKey
GAKMQHDJQHZUTJ-ULHLPKEOSA-N
Summenformel
C22H29FO4
Durchschnittliche Molmasse
376,5 g/mol
Monoisotopische Masse
376,20498763

Überblick

Fluocortolone is a 21-hydroxy steroid.

Namen und Bezeichner

Bevorzugter Name
Fluocortolone
IUPAC
(6S,8S,9S,10R,11S,13S,14S,16R,17S)-6-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one
Lokaler Name
Fluocortolon
Englischer Name
Fluocortolone
Summenformel
C22H29FO4
Molmasse
376.46

Namen und Synonyme

FLUOCORTOLONE152-97-6FlucortoloneFluocortolonaSH 742Fluocortolonum65VXC1MH0JSH-742Pregna-1,4-diene-3,20-dione, 6-fluoro-11,21-dihydroxy-16-methyl-, (6alpha,11beta,16alpha)-DTXSID00861835UltraproctUltradil
Weitere Namen anzeigen
FLUORCORTOLONEFluocortolonFluorocortoloneFluocortolone USP/EP/BPFluocortolone Impurity 13methylfluorodehydrocorticosterone
Ficoid 2-plusFicoid 2Caproate, FluocortolonePivalate, FluocortoloneRefChem:599356C05AA08D07AC05D07XC05

Datenbank-Bezeichner

CAS
152-97-6
PubChem CID
9053
DTXSID
DTXSID00861835
ChEMBL
CHEMBL251634
ChEBI
CHEBI:135581
UNII
65VXC1MH0J
EC Number
205-811-5
Nikkaji
J5.871H

Eigenschaften

Berechnete Struktureigenschaften

XLogP
2,4
Polarare Oberfläche (TPSA)
74,6 Ų
H-Brücken-Donoren
2
H-Brücken-Akzeptoren
5
Frei drehbare Bindungen
2
Schwere Atome
27

Experimentelle und physikochemische Eigenschaften

PFASPFAS -> Suspected persistent, mobile, toxic (PMT) PFAS or PFAS-like compounds
Drugs · 3 Einträge

Pharmaceuticals -> Dermatologicals -> Corticosteroids, dermatological preparations

Pharmaceuticals -> Listed in ZINC15

Pharmaceuticals -> Steroids

Human Drugs · 2 Einträge

Breast Feeding; Lactation; Milk, Human; Corticosteroids, Systemic; Glucocorticoids; Anti-Inflammatory Agents

Pharmaceuticals

Melting Point180-182

Physikochemische Eigenschaften

Schmelzpunkt
113 · 113-116°C
Siedepunkt
537.4 · 537.4±50.0 °C(Predicted)
Dichte
1.1001 · 1.1001 (estimate)
Dampfdruck
0.001 Pa · 0.001Pa at 25℃
storage temp.
Refrigerator
Löslichkeit
Chloroform (Slightly), Dioxane (Slightly), Methanol (Slightly)

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 4 Einträge

Danger

H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]

P203, P260, P264, P270, P280, P301+P316, P318, P319, P321, P330, P405, and P501 (click each P-code to see the statement)

The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Gefahrenhinweise

Regulatory InformationStatus: Active Update: 14-04-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/19646
Hazard Classes and CategoriesAcute Tox. 3 (100%)

Toxikologische Informationen

Effects During Pregnancy and Lactation◉ Summary of Use during Lactation

Sicherheitsdaten

Alarmwort
Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code H301

Chemie und Industrie

Pharmakologische Informationen

ATC Code · 6 Einträge

D - Dermatologicals

C - Cardiovascular system

H - Systemic hormonal preparations, excl. sex hormones and insulins

D - Dermatologicals

QD - Dermatologicals

QD - Dermatologicals

MeSH Pharmacological Classification · 2 Einträge

Substances that reduce or suppress INFLAMMATION.

A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.

Verwendung und Herstellung

UsesUse (kg; approx.) in Germany (2009): >10
Use ClassificationPharmaceuticals

Anwendungen

VerwendenFluocortolone is a glucocorticoid used in the treatment of several conditions, including hemorrhoids. Fluocortolone is similar to Fluocortin, but with one less keto group.

Vor- und nachgelagerte Produkte

Anbieter30 Anbieter

上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
武汉敬康恩生物医药科技有限公司13720134139 086-15871494362 13720134139 · [email protected]
艾吉析科技（上海）有限公司17717235263 · [email protected]
广州佳途科技股份有限公司81960175 18933936954 · [email protected]
廊坊市恒福源医药科技有限公司0316-2883537 19333636468 · [email protected]

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