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Fluocortolon
flucortolone · FLUORCORTOLONE · SH-742 · SH 742 · Fluocortolon · FLUOCORTOLONE · Fluorocortolone · Fluocortolone USP/EP/BP
Identifikatoren & physikalische Daten
| CAS No. | 152-97-6 |
|---|---|
| Summenformel | C22H29FO4 |
| Durchschnittliche Molmasse | 376,5 g/mol |
| Monoisotopische Masse | 376,20498763 g/mol |
| SMILES | C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@]2(C)[C@H]1C(=O)CO |
| InChIKey | GAKMQHDJQHZUTJ-ULHLPKEOSA-N |
| PubChem CID | 9053 |
| ChEMBL | CHEMBL251634 |
| ChEBI | CHEBI:135581 |
| EC No. | 205-811-5 |
| DTXSID | DTXSID00861835 |
| Lokaler Name | Fluocortolon |
Chemische & physikalische Eigenschaften
| XLogP | 2,4 |
|---|---|
| Polarare Oberfläche (TPSA) | 74,6 |
| H-Brücken-Donoren | 2 |
| H-Brücken-Akzeptoren | 5 |
| Frei drehbare Bindungen | 2 |
| Schwere Atome | 27 |
| Formalladung | 0 |
| Komplexität | 743 |
| PFAS | PFAS -> Suspected persistent, mobile, toxic (PMT) PFAS or PFAS-like compounds |
| Arzneimittel | Pharmaceuticals -> Dermatologicals -> Corticosteroids, dermatological preparationsPharmaceuticals -> Listed in ZINC15Pharmaceuticals -> Steroids |
| Human Drugs | Breast FeedingLactationMilk, HumanCorticosteroids, SystemicGlucocorticoidsAnti-Inflammatory AgentsPharmaceuticals |
| Schmelzpunkt | 180-182113-116°C |
| Siedepunkt | 537.4±50.0 °C(Predicted) |
| Dichte | 1.1001 (estimate) |
| Dampfdruck | 0.001Pa at 25℃ |
| Lagerbedingungen | Refrigerator |
| Löslichkeit | Chloroform (Slightly), Dioxane (Slightly), Methanol (Slightly)204mg/L at 20℃ |
| Aggregatzustand | Solid |
| pKa (Säurekonstante) | 12.98±0.10(Predicted) |
| Farbe | Pale Yellow to Yellow |
| LogP (Verteilungskoeffizient) | 2.3 at 25℃ |
Sicherheit & Vorschriften
| GHS-Einstufung | DangerH301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]P203, P260, P264, P270, P280, P301+P316, P318, P319, P321, P330, P405, and P501 (click each P-code to see the statement)The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory. |
|---|---|
| Regulatorische Informationen | Status: Active Update: 14-04-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/19646 |
| Hazard Classes and Categories | Acute Tox. 3 (100%) |
| Effects During Pregnancy and Lactation | ◉ Summary of Use during Lactation |
| Alarmwort | Achtung |
| Gefahrenhinweise | Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code H301 |
Anwendungen & Verwendung
Verwenden
Fluocortolone is a glucocorticoid used in the treatment of several conditions, including hemorrhoids. Fluocortolone is similar to Fluocortin, but with one less keto group.