4-Nitroso-N-phenylanilin

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SMALL SPILLS AND LEAKAGE: If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then dampen the solid spill material with toluene, then transfer the dampened material to a suitable container. Use absorbent paper dampened with toluene to pick up any remaining material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent-wash all contaminated surfaces with toluene followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

0.58 [mg/m3]

6.4 [mg/m3]

39 [mg/m3]

MINIMUM PROTECTIVE CLOTHING: If Tyvek-type disposable protective clothing is not worn during handling of this chemical, wear disposable Tyvek-type sleeves taped to your gloves.

Wear nitrile rubber gloves, protective laboratory coat, self-contained breathing apparatus, eye protection and protective shoes. /Nitrosamines/

The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical. [http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=156-10-5]

para-Nitrosodiphenylamine

Group 3: Not classifiable as to its carcinogenicity to humans

Volume 27: (1982) Some Aromatic Amines, Anthraquinones and Nitroso Compounds, and Inorganic Fluorides Used in Drinking-water and Dental Preparations

1987

1987

p-Nitrosodi-phenylamine

TWO GROUPS OF 50 MALE AND 50 FEMALE B6C3F1 MICE, SIX WEEKS OF AGE, WERE FED DIETS CONTAINING PARA-NITROSODIPHENYLAMINE (TECHNICAL GRADE, 73% ACTIVE MATERIAL, 25% WATER, WITH UNSPECIFIED IMPURITIES). THE LOW DOSE GROUP RECEIVED 5000 MG/KG OF DIET FOR 40 WEEKS, THEN 2500 MG/KG FOR 17 WEEKS; THE HIGH DOSE GROUP RECEIVED 10000 MG/KG OF DIET FOR 40 WEEKS, THEN, AFTER A SEVEN WEEK INTERVAL, 5000 MG/KG FOR 10 WEEKS. BOTH GROUPS WERE OBSERVED FOR AN ADDITIONAL 35 WEEKS. A GROUP OF 20 ANIMALS OF EACH SEX SERVED AS MATCHED CONTROLS AND WERE KEPT UNDER OBSERVATION FOR 92 WEEKS. OF THE HIGH DOSE GROUP, 19 MALES AND 21 FEMALES DIED BEFORE 52 WEEKS DUE TO TOXICITY. BY THE END OF THE STUDY, 85, 88, AND 60% OF MALES AND 90, 84 AND 52% OF THE FEMALES WERE STILL ALIVE IN THE CONTROL, LOW DOSE AND HIGH DOSE GROUPS, RESPECTIVELY. A STATISTICALLY SIGNIFICANT INCREASE IN INCIDENCE OF LIVER TUMORS WAS OBSERVED IN TREATED MALE MICE ONLY: HEPATOCELLULAR CARCINOMA OR ADENOMA- 2/18 IN CONTROLS, 22/42 IN LOW DOSE ANIMALS (P= 0.002) AND 12/13 IN THE HIGH DOSE ANIMALS (P= 0.038); INCIDENCES OF HEPATOCELLULAR CARCINOMAS ALONE WERE 0/18, 10/42 (P= 0.02) AND 1/31 IN THE THREE GROUPS, RESPECTIVELY.

IN A FOUR WEEK SUBCHRONIC STUDY, FISCHER 344 RATS AND B6C3F1 MICE WERE FED DIETS CONTAINING UP TO 3.2% AND 2.6% PARA-NITROSODIPHENYLAMINE, RESPECTIVELY. THERE WAS DOSE RELATED MORTALITY IN MALE AND FEMALE MICE, BUT NOT IN RATS. THE RATS SHOWED A DOSE DEPENDENT DEPRESSION OF MEAN BODY WEIGHT GAIN OF UP TO 53%.

PARA-NITROSODIPHENYLAMINE DID NOT TRANSFORM CELLS OF EMBRYOS EXCISED FROM PREGNANT HAMSTERS TREATED INTRAPERITONEALLY WITH UP TO 20 MG/KG BODY WEIGHT.

A bioassay of N-nitrosodiphenylamine for possible carcinogenicity was /administered in/ feed to mice and rats. Rats of each sex received either 1000 or 4000 ppm for 100 weeks. Male mice received 10,000 or 20,000 ppm for 101 weeks. Female mice received either 2315 or 5741 ppm (Time-weighted average). Carcinogenesis occurred in both sexes of rats, with transitional cell carcinomas of the urinary bladder, but not in the mice. /N-Nitrosodiphenylamine/

p-Nitrosodiphenylamine showed no evidence of potential carcinogenicity in an in vivo-in vitro combination bioassay. Pregnant Syrian golden hamsters were given an intraperitoneal injection of 0.5 ml of a solution containing 0.5 to 2 mg of the chemical per 100 gm maternal weight on day 10 or 11 of gestation. Embryos were excised at day 13, and cells from these embryos were cultured and scored for transformation. No transformed cells were observed. Subcutaneous injection of the cultured cells into weanling, male hamsters produced no tumors.

No data are available in humans. Inadequate evidence of carcinogenicity in animals. OVERALL EVALUATION: Group 3: The agent is not classifiable as to its carcinogenicity to humans.

4-Nitrosodiphenylamine: delisted as reasonably anticipated to be a human carcinogen.

A bioassay for the possible carcinogenicity of p-nitrosodiphenylamine was conducted using Fischer 344 rats and B6C3F1 mice. p-Nitrosodiphenylamine was administered in the feed ... /to/ 50 male and 50 female animals of each species. Twenty animals of each sex and species were placed on test as controls. The high and low dietary concentrations of p-nitrosodiphenylamine were, respectively, 5000 and 2500 ppm for rats. The high and low time-weighted average concentrations for mice were 9000 and 4254 ppm, respectively. The compound was administered for 78 weeks to rats, for 50 weeks to high dose mice and for 57 weeks to low dose mice. The period of compound administration was followed by an observation period of 27 weeks for rats and 35 weeks for mice. There were significant positive associations between the concentrations of p-nitrosodiphenylamine administered and mortality among male and female mice, but not for rats of either sex. ... Under the conditions of this bioassay, p-nitrosodiphylamine was carcinogenic when administered in the diet to male B6C3F1 mice, causing hepatocellular carcinomas. The chemical was also carcinogenic in male Fischer 344 rats, causing liver neoplasms. No evidence was provided for the carcinogenicity of p-nitrosodiphenylamine in female B6C3F1 mice or in female Fischer 344 rats.

6.3e-06

CALEPA

0.022

CALEPA