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[(Naphthyloxy)methyl]oxiran
NAPHTHYL GLYCIDYL ETHER · Propranolol Epoxide impurity · 2-[(1-Naphthalenyloxy)Methyl]oxirane · EPOXY IMPURITY · UNII:07FN14F351 · Propranolol Epoxide · Propranolol PEP2 Std · Naftopidil Impurity 1
![Molekülstruktur von [(Naphthyloxy)methyl]oxiran](/img/chemical/91521.png)
Identifikatoren & physikalische Daten
| CAS No. | 2461-42-9 |
|---|---|
| Summenformel | C13H12O2 |
| Durchschnittliche Molmasse | 200,23 g/mol |
| Monoisotopische Masse | 200,08372962 g/mol |
| SMILES | c1ccc2c(OCC3CO3)cccc2c1 |
| InChIKey | QYYCPWLLBSSFBW-UHFFFAOYSA-N |
| PubChem CID | 91521 |
| ChEMBL | CHEMBL1929345 |
| EC No. | 219-555-7 |
| DTXSID | DTXSID501030986 |
| Lokaler Name | [(Naphthyloxy)methyl]oxiran |
Chemische & physikalische Eigenschaften
| XLogP | 3,3 |
|---|---|
| Polarare Oberfläche (TPSA) | 21,8 |
| H-Brücken-Donoren | 0 |
| H-Brücken-Akzeptoren | 2 |
| Frei drehbare Bindungen | 3 |
| Schwere Atome | 15 |
| Formalladung | 0 |
| Komplexität | 217 |
| Polymers | Plastics & Rubber -> Glycidyl Ethers |
| Schmelzpunkt | 95 °C |
| Siedepunkt | 163-167 |
| Dichte | 1.192±0.06 g/cm3(Predicted) |
| Lagerbedingungen | Refrigerator |
| Löslichkeit | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| Aggregatzustand | Oil |
| Farbe | Clear Light Yellow |
| CAS Datenbank | 2461-42-9(CAS DataBase Reference) |
Sicherheit & Vorschriften
| GHS-Einstufung | WarningH302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]P203, P261, P264, P264+P265, P270, P271, P272, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P318, P319, P321, P330, P332+P317, P333+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 8 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| Regulatorische Informationen | Status: Active Update: 28-05-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/17936 |
| Gefahrenübersicht | Allergic contact dermatitis reported in resin handlers[Kanerva, p. 1799] |
| Hazard Classes and Categories | Acute Tox. 4 (50%) |
| Unerwünschte Wirkungen | Skin Sensitizer - An agent that can induce an allergic reaction in the skin. |
| Zollcode | 2910900090 |
Anwendungen & Verwendung
Beschreibung
Glycidyl ethers are used as reactive diluents for epoxy resins. Alpha-naphtyl glycidyl ether is formed by adding epichlorhydrin and sodium hydroxide to alpha-naphtol. Contact dermatitis was reported in workers of a chemical plant.
Verwenden
2-[(1-Naphthyloxy)methyl]oxirane is used in the preparation of Naftopidil (N213500) and propranolol (P831800).