alpha-Bicyclo(2.2.1)hept-5-en-2-yl-alphaphenyl)-1-piperidin-propanol-hydrochlorid
Biperiden Hydrochloride
Grundinformationen
- CAS
1235-82-1- Standard-SMILES
Cl.OC(CCN1CCCCC1)(c1ccccc1)C1CC2C=CC1C2- InChIKey
RDNLAULGBSQZMP-UHFFFAOYSA-N- Summenformel
- C21H30ClNO
- Durchschnittliche Molmasse
- 347,9 g/mol
- Monoisotopische Masse
- 347,2015923
Überblick
See also: Biperiden (has active moiety); Carapichea ipecacuanha (annotation moved to).
Namen und Bezeichner
- Bevorzugter Name
- Biperiden Hydrochloride
- IUPAC
- 1-(2-bicyclo[2.2.1]hept-5-enyl)-1-phenyl-3-piperidin-1-ylpropan-1-ol;hydrochloride
- Lokaler Name
- alpha-Bicyclo(2.2.1)hept-5-en-2-yl-alphaphenyl)-1-piperidin-propanol-hydrochlorid
- Englischer Name
- Biperiden hydrochloride
- Summenformel
- C21H30ClNO
- Molmasse
- 347.92
Namen und Synonyme
Biperiden hydrochloride1235-82-1Biperiden HClAkinophylTasmolinBiperideni hydrochloridumDTXSID2047856Akineton retK35N76CUHFNSC-84989NSC-1709501-Bicycloheptenyl-1-phenyl-3-piperidinopropanol-1 hydrochloride
Weitere Namen anzeigen
BIPERIDINE HCLBicamolAkiridenNSC 84989NSC 170950Biperidene HCLBiperideni ImpurityNSC 170950NSC 84989akinetonhydrochloride
DTXCID20278321-(bicyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-(piperidin-1-yl)propan-1-ol hydrochlorideCHEBI:591711-(bicyclo(2.2.1)hept-5-en-2-yl)-1-phenyl-3-(piperidin-1-yl)propan-1-ol hydrochlorideRefChem:575271-(Bicyclo(2.2.1)hept-5-en-2-yl)-1-phenyl-3-(piperidin-1-yl)propan-1-ol monohydrochloride214-976-2Akineton
Datenbank-Bezeichner
- CAS
1235-82-1
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 23,5 Ų
- H-Brücken-Donoren
- 2
- H-Brücken-Akzeptoren
- 2
- Frei drehbare Bindungen
- 5
- Schwere Atome
- 24
- Formalladung
- 0
- Komplexität
- 422
Experimentelle und physikochemische Eigenschaften
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Physikochemische Eigenschaften
- Schmelzpunkt
- 238 ° · 238°
- storage temp.
- 2 · 2-8°C
- Löslichkeit
- 20 mg/mL · DMSO: >20mg/mL
- Aggregatzustand
- powder
- Farbe
- off-white
- BCS Class
- 3 · 3/1
- Major Application
- pharmaceutical (small molecule)
- InChI
- InChI=1/C21H29NO.ClH/c23-21(19-7-3-1-4-8-19,11-14-22-12-5-2-6-13-22)20-16-17-9-10-18(20)15-17;/h1,3-4,7-10,17-18,20,23H,2,5-6,11-16H2;1H/t17-,18+,20,21;/s3
- InChIKey
- RDNLAULGBSQZMP-PHPHQDSFNA-N
- SMILES
- C1(C[C@]2([H])C=C[C@@]1([H])C2)C(O)(CCN1CCCCC1)C1C=CC=CC=1.Cl |&1:2,6,r|
- NIST chemische Informationen
- Akineton, hydrochloride(1235-82-1)
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Danger
H228 (66.9%): Flammable solid [Danger Flammable solids]
P210, P240, P241, P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P304+P340, P305+P351+P338, P317, P330, P337+P317, P370+P378, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 157 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Hazard Classes and CategoriesFlam. Sol. 1 (66.9%)
Toxikologische Informationen
Drug Induced Liver Injury
Drug Induced Liver Injury Rank (DILIrank 2.0)
Biperiden hydrochloride
vNo-DILI-concern
0
No match
DOI:10.1016/j.drudis.2016.02.015
Sicherheitsdaten
- wgk
- 3
- RTECS-Nr.
- TN3706000
- risk_code
- 22-R22
- Toxizität
- LD50 in rats, dogs (mg/kg): 750, 340 orally (Hanna)
- hazard_code
- Xn
- Speicherklasse
- 11 - Combustible Solids
- Hazard Classifications
- Acute Tox. 4 Oral
Chemie und Industrie
Pharmakologische Informationen
MeSH Pharmacological Classification
Agents used in the treatment of Parkinson's disease. The most commonly used drugs act on the dopaminergic system in the striatum and basal ganglia or are centrally acting muscarinic antagonists.
Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS.
Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system.
Anwendungen
VerwendenBiperiden hydrochloride is antiparkinsonian; non-selective muscarinic receptor antagonist. Biperiden is used for the adjunctive treatment of all forms of Parkinson′s Disease (postencephalitic, idiopathic, and arteriosclerotic); also commonly used to improve parkinsonian signs and symptoms related to antipsychotic drug therapy.
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