HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
alpha-Bicyclo(2.2.1)hept-5-en-2-yl-alphaphenyl)-1-piperidin-propanol-hydrochlorid
BIPERIDINE HCL · Bicamol · Tasmolin · Akiriden · NSC 84989 · NSC 170950 · Biperidene HCL · Biperideni Impurity
Identifikatoren & physikalische Daten
| CAS No. | 1235-82-1 |
|---|---|
| Summenformel | C21H30ClNO |
| Durchschnittliche Molmasse | 347,9 g/mol |
| Monoisotopische Masse | 347,2015923 g/mol |
| SMILES | Cl.OC(CCN1CCCCC1)(c1ccccc1)C1CC2C=CC1C2 |
| InChIKey | RDNLAULGBSQZMP-UHFFFAOYSA-N |
| PubChem CID | 92151 |
| ChEMBL | CHEMBL1201035 |
| EC No. | 214-976-2 |
| DTXSID | DTXSID2047856 |
| Lokaler Name | alpha-Bicyclo(2.2.1)hept-5-en-2-yl-alphaphenyl)-1-piperidin-propanol-hydrochlorid |
Chemische & physikalische Eigenschaften
| Polarare Oberfläche (TPSA) | 23,5 |
|---|---|
| H-Brücken-Donoren | 2 |
| H-Brücken-Akzeptoren | 2 |
| Frei drehbare Bindungen | 5 |
| Schwere Atome | 24 |
| Formalladung | 0 |
| Komplexität | 422 |
| Human Drugs | FDA approved drugs -> Active ingredient |
| Schmelzpunkt | 238° |
| Lagerbedingungen | 2-8°C |
| Löslichkeit | DMSO: >20mg/mL |
| Aggregatzustand | powder |
| Farbe | off-white |
| BCS Class | 3/1 |
| Hauptanwendungen | pharmaceutical (small molecule) |
| InChI | InChI=1/C21H29NO.ClH/c23-21(19-7-3-1-4-8-19,11-14-22-12-5-2-6-13-22)20-16-17-9-10-18(20)15-17/h1,3-4,7-10,17-18,20,23H,2,5-6,11-16H21H/t17-,18+,20,21/s3 |
| InChIKey | RDNLAULGBSQZMP-PHPHQDSFNA-N |
| SMILES | C1(C[C@]2([H])C=C[C@@]1([H])C2)C(O)(CCN1CCCCC1)C1C=CC=CC=1.Cl |&1:2,6,r| |
| NIST chemische Informationen | Akineton, hydrochloride(1235-82-1) |
Sicherheit & Vorschriften
| GHS-Einstufung | DangerH228 (66.9%): Flammable solid [Danger Flammable solids]P210, P240, P241, P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P304+P340, P305+P351+P338, P317, P330, P337+P317, P370+P378, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 157 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| Hazard Classes and Categories | Flam. Sol. 1 (66.9%) |
| Drug Induced Liver Injury | Drug Induced Liver Injury Rank (DILIrank 2.0)Biperiden hydrochloridevNo-DILI-concernNo matchDOI:10.1016/j.drudis.2016.02.015 |
| Wassergefährdungsklasse (WGK) | 3 |
| RTECS-Nr. | TN3706000 |
| R-Sätze (R) | 22-R22 |
| Toxizität | LD50 in rats, dogs (mg/kg): 750, 340 orally (Hanna) |
| Gefahrensymbole | Xn |
| Lagerklasse | 11 - Combustible Solids |
| Gefahrenklasse | Acute Tox. 4 Oral |
Anwendungen & Verwendung
Verwenden
Biperiden hydrochloride is antiparkinsonian; non-selective muscarinic receptor antagonist. Biperiden is used for the adjunctive treatment of all forms of Parkinson′s Disease (postencephalitic, idiopathic, and arteriosclerotic); also commonly used to improve parkinsonian signs and symptoms related to antipsychotic drug therapy.