Tromethamine hydrochloride (HCID 93573)

Namen und Bezeichner

Bevorzugter Name: Tromethamine hydrochloride
IUPAC: 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydrochloride
Lokaler Name: 2-Amino-2-(hydroxymethyl)propan-1,3-diolhydrochlorid
Englischer Name: TRIS hydrochloride
Summenformel: C4H12ClNO3
Molmasse: 157.6

Namen und Synonyme

1185-53-1Tris hydrochlorideTris(hydroxymethyl)aminomethane hydrochlorideTromethamine hydrochloride2-Amino-2-(hydroxymethyl)propane-1,3-diol hydrochlorideTRIS HClTris-HClTrometamol hydrochlorideTrizma hydrochlorideTromethamine HCl1,3-Propanediol, 2-amino-2-(hydroxymethyl)-, hydrochlorideTris chloride

Weitere Namen anzeigen

Tris-HCITRIS-HCL BUFFERTris-HCTRIS-HC1Tris hydrochloric acid

DTXSID4044373Tris hydrochloride bufferUNII-383V75M34EEINECS 214-684-5383V75M34E2-Amino-2-hydroxymethyl-1,3-propanediol hydrochlorideDTXCID2024373TROMETAMOL HYDROCHLORIDE [WHO-DD]

Datenbank-Bezeichner

CAS: 1185-53-1
PubChem CID: 93573
DTXSID: DTXSID4044373
ChEMBL: CHEMBL3183206
UNII: 383V75M34E
EC Number: 214-684-5

Eigenschaften

Berechnete Struktureigenschaften

Polarare Oberfläche (TPSA): 86,7 Å²
H-Brücken-Donoren: 5
H-Brücken-Akzeptoren: 4
Frei drehbare Bindungen: 3
Schwere Atome: 9
Formalladung: 0
Komplexität: 54

Experimentelle und physikochemische Eigenschaften

Chemical ClassesNitrogen Compounds -> Amino Alcohols, Other

Physical Description · 2 Einträge

Dry Powder; Liquid; Other Solid; Dry Powder

Hygroscopic solid; [Sigma-Aldrich MSDS]

Physikochemische Eigenschaften

Schmelzpunkt: 150 · 150-152 °C
Siedepunkt: 225 ℃[at · 225℃[at 101 325 Pa]
Dichte: 1.05 g/mL · 1.05 g/mL at 20 °C
Dampfdruck: 0 Pa · 0Pa at 20℃
storage temp.: room temp
Löslichkeit: 2 O: · H2O: 4 M at 20 °C, clear, colorless
Aggregatzustand: crystalline
Farbe: clear colorless (40 % (w/w) in H2O) solution
PH: 2.5 · 2.5-4.0 (25℃, 4M in H2O)
pka: 8.1 · 8.1(at 25℃)
Biologische Quelle: synthetic
Wasserlöslichkeit: SOLUBLE
BRN: 3675235 · 3675235
Stabilität: Stable. Incompatible with strong oxidizing agents, bases, moisture.
Kosmetik-Inhaltsstoffe Funktionen: ANTIMICROBIAL
InChI: 1S/C4H11NO3.ClH/c5-4(1-6,2-7)3-8;/h6-8H,1-3,5H2;1H
InChIKey: QKNYBSVHEMOAJP-UHFFFAOYSA-N
SMILES: Cl.NC(CO)(CO)CO
LogP: -3.6 at · -3.6 at 20℃
CAS Datenbank: 1185 · 1185-53-1(CAS DataBase Reference)
EPA chemische Informationen: 1 · 1,3-Propanediol, 2-amino-2-(hydroxymethyl)-, hydrochloride (1185-53-1)
Absorption: 0.05 at · ≤0.05 at 290nm at 40%

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 5 Einträge

This chemical does not meet GHS hazard criteria for 57.2% (103 of 180) of all reports.

Warning

H315 (42.2%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 180 reports by companies from 16 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Gefahrenhinweise

Regulatory Information · 4 Einträge

Chemical: 1,3-Propanediol, 2-amino-2-(hydroxymethyl)-, hydrochloride

1,3-Propanediol, 2-amino-2-(hydroxymethyl)-, hydrochloride (1:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,3-Propanediol, 2-amino-2-(hydroxymethyl)-, hydrochloride (1:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 09-12-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/19306

2-amino-2-(hydroxymethyl)propane-1,3-diol: Does not have an individual approval but may be used under an appropriate group standard

Hazards SummaryA mild eye irritant in rabbits; Not a sensitizer in experimental animals; [Sigma-Aldrich MSDS] See Tromethamine.

Hazard Classes and CategoriesSkin Irrit. 2 (42.2%)

Sicherheit und Schutzausrüstung

Protective Action Criteria (PAC) · 3 Einträge

18 [mg/m3]

190 [mg/m3]

1200 [mg/m3]

Sicherheitsdaten

F: 3
wgk: 3
tsca: TSCA listed
hs_code: 29221980
RTECS-Nr.: TY2900000
risk_code: 36/37/38
hazard_code: Xi
safety_code: 26-36
Speicherklasse: 11 - Combustible Solids

Chemie und Industrie

Verwendung und Herstellung

UsesUsed to make surface-active agents and pharmaceuticals, as an emulsifier (for cosmetic creams and lotions, mineral oil, and paraffin wax emulsions), as a biological buffer, and as an alkalizer; [ChemIDplus]

U.S. Production2023: 400,000 - <550,000 lb

Consumer UsesStabilizing agent

Industry UsesOther

General Manufacturing Information · 2 Einträge

All Other Chemical Product and Preparation Manufacturing

1,3-Propanediol, 2-amino-2-(hydroxymethyl)-, hydrochloride (1:1): ACTIVE

Anwendungen · 2 Einträge

BeschreibungAbbreviated as Tris HCl (TRIS hydrochloride), Tris (hydroxymethyl) aminomethane hydrochloride is an organic compound commonly utilized in buffer solutions such as TAE or TBE for electrophoresis gels. It boasts high solubility in water and offers utility within the pH range of 7.0-9.0.

VerwendenTris Hydrochloride is a buffering medium for electrophoresis, molecular biology, and cell culture applications. It may be combined with Tris Base to simplify Tris buffer preparation. Tris Hydrochloride has been incorporated in coelomic fluid and in Cortland medium to store unfertilized rainbow trout eggs. In immunohistochemistry, Tris Hydrochloride has also been used with urea as a method for antigen retrieval.

Darstellung · 1 Eintrag

synthetischeThe preparation of TRIS hydrochloride is as follows:After reacting 2-amino-1,3-propanediol (2.50 g, 27.44 mmol) and formic acid (1.26 g, 27.44 mmol) in 50 ml of water at room temperature for 3 hours, water was distilled off under reduced pressure, A liquid was obtained. By washing the obtained liquid,An ammonium formate salt (3.76 g, 27.44 mmol) was obtained as a colorless transparent liquid.